INT4738

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2009
Negated 2
Speculated 3
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 2.41
Pain Relevance 7.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
frontal cortex 2
NAc 1
neurons 1
brain 1
band 1
Ppp1r1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 97 100.00 Very High Very High Very High
cocaine 46 100.00 Very High Very High Very High
monoamine 17 100.00 Very High Very High Very High
adenocard 1 99.92 Very High Very High Very High
amygdala 34 99.56 Very High Very High Very High
Morphine 25 99.54 Very High Very High Very High
Enkephalin 5 99.34 Very High Very High Very High
fluoxetine 15 99.24 Very High Very High Very High
nMDA receptor antagonist 2 99.22 Very High Very High Very High
antidepressant 15 96.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 21 100.00 Very High Very High Very High
Dyskinesias 10 99.82 Very High Very High Very High
Aids-related Complex 7 82.36 Quite High
Parkinson's Disease 19 50.00 Quite Low
Disease 27 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we investigated the alterations on phospho-Ser133 CREB, phospho-Thr34 DARPP-32 and phospho-Thr75 DARPP-32 induced by continuous infusions of cocaine, GBR12909, fluoxetine and nisoxetine.
Spec (investigated) Regulation (alterations) of DARPP-32 associated with fluoxetine and cocaine
1) Confidence 0.49 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.59
Here we investigated the alterations on phospho-Ser133 CREB, phospho-Thr34 DARPP-32 and phospho-Thr75 DARPP-32 induced by continuous infusions of cocaine, GBR12909, fluoxetine and nisoxetine.
Spec (investigated) Regulation (alterations) of DARPP-32 associated with fluoxetine and cocaine
2) Confidence 0.49 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.60
Lithium regulation of DARPP-32 immunoreactivity required chronic drug administration and was not observed in several other brain regions examined.
Regulation (regulation) of DARPP-32 in brain
3) Confidence 0.45 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.31 Pain Relevance 0.26
Following treatment of the non-competitive NMDA receptor antagonist dizocilpine (MK-801), the LID-induced changes in PDyn mRNA, phospho-Thr-34 DARPP-32 and phospho-Thr-75 DARPP-32 were largely reversed.
Regulation (changes) of DARPP-32 associated with nmda receptor antagonist and dyskinesias
4) Confidence 0.38 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17884291 Disease Relevance 0.43 Pain Relevance 0.09
Following treatment of the non-competitive NMDA receptor antagonist dizocilpine (MK-801), the LID-induced changes in PDyn mRNA, phospho-Thr-34 DARPP-32 and phospho-Thr-75 DARPP-32 were largely reversed.
Regulation (changes) of DARPP-32 associated with nmda receptor antagonist and dyskinesias
5) Confidence 0.38 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17884291 Disease Relevance 0.43 Pain Relevance 0.09
They contained striatum-like patches with neurons expressing many of the neurochemicals characteristic of striatum (ACh, ChAT, calbindin-D28KD, met-enkephalin, and dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein-32,000 or DARPP-32), and these patches were surrounded by graft tissue expressing few of these striatal markers.
Regulation (5'-monophosphate-regulated) of DARPP-32 in neurons associated with adenocard, dopamine and enkephalin
6) Confidence 0.30 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1279138 Disease Relevance 0 Pain Relevance 0.27
We identified one heavily regulated phosphoprotein in frontal cortex as the 32-kDa dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32).
Regulation (regulated) of DARPP-32 in frontal cortex associated with dopamine and urological neuroanatomy
7) Confidence 0.27 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.24 Pain Relevance 0.21
Immunoblot experiments demonstrated that chronic lithium regulation of DARPP-32 back-phosphorylation is associated with equivalent increases in levels of DARPP-32 immunoreactivity.
Regulation (regulation) of DARPP-32
8) Confidence 0.27 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.29 Pain Relevance 0.22
Immunoblot experiments demonstrated that chronic lithium regulation of DARPP-32 back-phosphorylation is associated with equivalent increases in levels of DARPP-32 immunoreactivity.
Regulation (immunoreactivity) of DARPP-32
9) Confidence 0.27 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.30 Pain Relevance 0.26
Moreover, chronic administration of the antidepressant imipramine or tranylcypromine produced a similar increase in levels of DARPP-32 in frontal cortex, whereas other types of psychotropic drugs, including haloperidol, morphine, and cocaine, did not influence DARPP-32 levels.
Neg (not) Regulation (influence) of DARPP-32 in frontal cortex associated with antidepressant, urological neuroanatomy, cocaine and morphine
10) Confidence 0.24 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.34 Pain Relevance 0.32
Dopamine and cyclic AMP-regulated phosphoprotein-32 phosphorylation pattern in cocaine and morphine-sensitized rats.
Regulation (regulated) of phosphoprotein-32 associated with dopamine, morphine and cocaine
11) Confidence 0.23 Published 2004 Journal J. Neurochem. Section Title Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.02
Cocaine-sensitized rats showed increased phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein Mr 32 kDa (DARPP-32) at threonine-75 (Thr75) and decreased DARPP-32 phosphorylation at Thr34, in the caudate-putamen (CPu) and nucleus accumbens (NAc) 7 days after sensitization assessment.
Regulation (regulated) of DARPP-32 in NAc associated with nucleus accumbens, dopamine and cocaine
12) Confidence 0.23 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 0.83
No alterations were observed on phospho-Thr75 DARPP-32 levels.
Neg (No) Regulation (alterations) of DARPP-32
13) Confidence 0.21 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.68
Since multiple cAMP response element (CRE) sequences are present on the prodynorphin gene promoter, the aim of our study was to investigate the effects of cocaine and monoaminergic uptake inhibitors on CREB and DARPP-32 phosphorylation and moreover the possible correlation with the changes already observed on prodynorphin gene expression.
Spec (investigate) Regulation (effects) of DARPP-32 associated with monoamine and cocaine
14) Confidence 0.18 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.56
Alterations of CREB and DARPP-32 phosphorylation following cocaine and monoaminergic uptake inhibitors.
Regulation (Alterations) of DARPP-32 associated with monoamine and cocaine
15) Confidence 0.18 Published 2007 Journal Brain Res. Section Title Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.41
DARPP-32 is expressed at high levels within the BST and CeA with lower levels of DARPP-32 immunoreactivity within the mPOA and VHM [51].
Regulation (immunoreactivity) of DARPP-32 associated with amygdala
16) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.08 Pain Relevance 0.65
Background values from an equivalent area near each lane were subtracted from each band to calculate mean band density and iNOS or DARPP-32 immunoreactivity was normalized by density of ?
Regulation (immunoreactivity) of DARPP-32 in band
17) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2674956 Disease Relevance 0 Pain Relevance 0.03

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