INT47386

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Context Info
Confidence 0.29
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.63
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
hippocampus 1
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 14 100.00 Very High Very High Very High
Neurotransmitter 8 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Buprenorphine 176 99.44 Very High Very High Very High
Hippocampus 28 98.96 Very High Very High Very High
Fibrositis 154 94.16 High High
opioid receptor 74 93.12 High High
Central nervous system 5 90.84 High High
excitatory amino acid 4 90.72 High High
Nucleus accumbens 2 90.20 High High
Disease Link Frequency Relevance Heat
Fibromyalgia 154 94.16 High High
Liver Disease 2 92.00 High High
Hepatic Encephalopathy 2 90.24 High High
Hematologic Neoplasms 3 89.72 High High
Stroke 2 87.76 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 86.88 High High
Pressure And Volume Under Development 12 81.12 Quite High
Breast Cancer 14 80.48 Quite High
Cancer 38 79.24 Quite High
Pain 102 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Choline acetyltransferase specific activity was reduced 80%.
Negative_regulation (reduced) of Choline acetyltransferase
1) Confidence 0.29 Published 1981 Journal Teratology Section Abstract Doc Link 7336361 Disease Relevance 0 Pain Relevance 0.09
Our findings of a significant decrease in histone acetylase activity as measured by an ELISA assay in five of five patients further support the clinical use of this agent.
Negative_regulation (decrease) of acetylase
2) Confidence 0.03 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.30 Pain Relevance 0
Prenatal buprenorphine exposure also results in a decrease in choline acetyltransferase mRNA in postnatal offspring [318] although striatal mRNA levels for the ?
Negative_regulation (decrease) of choline acetyltransferase associated with buprenorphine
3) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0.06 Pain Relevance 0.84
In particular, there are consistent decreases in protein, DNA, RNA and neurotransmitter content (serotonin, dopamine, norepinephrine) [87, 145, 253, 301, 344], enzymatic protein levels (tyrosine hydroxylase, acetylcholine-esterase, choline acetyltransferase, ornithine decarboxylase) [87, 224, 327, 338, 342, 343], and receptor expression (?
Negative_regulation (decreases) of choline acetyltransferase associated with dopamine, neurotransmitter and serotonin
4) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.67
The reduction in the intracellular choline (Cho) levels is also a likely mechanism to compensate for hyperosmolarity [36].
Negative_regulation (reduction) of choline
5) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945024 Disease Relevance 0.70 Pain Relevance 0.43
Our study confirms the reduction in choline and NAA+NAAG in the left hippocampus (P = 0.019 and P = 0.034, respectively).
Negative_regulation (reduction) of choline in hippocampus associated with hippocampus
6) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945024 Disease Relevance 0.57 Pain Relevance 0.58

General Comments

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