INT4739

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 2.83
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calb1) nucleus (Calb1) intracellular (Calb1)
cytoplasm (Calb1)
Anatomy Link Frequency
neurons 4
ileum 2
sensory nerve 2
neuronal 1
pyramidal neurons 1
Calb1 (Rattus norvegicus)
Calb1 - D28K (8)
Pain Link Frequency Relevance Heat
Neuropeptide 44 100.00 Very High Very High Very High
Glutamate 38 100.00 Very High Very High Very High
Enkephalin 19 99.76 Very High Very High Very High
narcan 11 99.72 Very High Very High Very High
Morphine 20 99.62 Very High Very High Very High
Dopamine 8 99.12 Very High Very High Very High
adenocard 5 98.56 Very High Very High Very High
substance P 58 97.60 Very High Very High Very High
Pyramidal cell 24 97.24 Very High Very High Very High
Somatostatin 43 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 216 98.96 Very High Very High Very High
Kidney Stones 48 97.40 Very High Very High Very High
Status Epilepticus 57 84.04 Quite High
Drug Dependence 2 82.88 Quite High
Body Weight 12 79.64 Quite High
Apoptosis 13 77.68 Quite High
Nociception 1 71.28 Quite High
Angina 1 57.88 Quite High
Loss Of Sense Of Smell 22 50.00 Quite Low
Epilepsy 16 38.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of calbindin-D28K gene expression in response to acute and chronic morphine administration.
Gene_expression (expression) of calbindin-D28K (D28K) associated with narcan and morphine
1) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8028477 Disease Relevance 0.08 Pain Relevance 1.03
The effect of acute and chronic morphine administration on calbindin-D28K (calbindin) gene expression has been studied.
Gene_expression (expression) of calbindin-D28K (D28K) associated with morphine
2) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8028477 Disease Relevance 0.08 Pain Relevance 0.60
Immunohistochemical studies of other sensory nerve populations have successfully used the expression of proton pump isozymes, vesicular glutamate transporters (vGluts; a marker for glutamatergic neurons), neuropeptides and calcium binding proteins (such as calretinin, calbindin and parvalbumin) as useful markers for characterizing sensory nerve subtypes.
Gene_expression (expression) of calbindin in sensory nerve associated with glutamate and neuropeptide
3) Confidence 0.75 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.40 Pain Relevance 0.50
In addi</span>tion, some endocrine-like cells of the <span style="background-color:#FFDEAD">ileum were calbindin-D28K-positive.
Gene_expression (positive) of calbindin-D28K-positive (D28K) in ileum
4) Confidence 0.66 Published 1988 Journal Biol. Cell Section Abstract Doc Link 2461241 Disease Relevance 0 Pain Relevance 0.29
In addi</span>tion, some endocrine-like cells of the <span style="background-color:#FFDEAD">ileum were calbindin-D28K-positive.
Gene_expression (positive) of calbindin-D28K-positive (D28K) in ileum
5) Confidence 0.66 Published 1988 Journal Biol. Cell Section Abstract Doc Link 2461241 Disease Relevance 0 Pain Relevance 0.29
Immunohistochemical studies of other sensory nerve populations have successfully used the expression of proton pump isozymes, vesicular glutamate transporters (vGluts; a marker for glutamatergic neurons), neuropeptides and calcium binding proteins (such as calretinin, calbindin and parvalbumin) as useful markers for characterizing sensory nerve subtypes.
Gene_expression (isozymes) of calbindin in sensory nerve associated with glutamate and neuropeptide
6) Confidence 0.65 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.40 Pain Relevance 0.49
A final interesting observation to arise from the present studies was the distinct lack of expression of calretinin, calbindin or parvalbumin in nodose cough receptor neurons.
Gene_expression (expression) of calbindin in neurons associated with cough
7) Confidence 0.58 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.39 Pain Relevance 0.09
The expression levels of representative genes, i.e., calbindin-D9k (CaBP-9k; vitamin D-dependent calcium-binding protein), oxytocin, adipocyte complement related protein (MW 30 kDa), lactate dehydrogenase A and calcium binding protein A6 (S100a6; calcyclin), were confirmed in these tissues by real-time PCR.
Gene_expression (expression) of vitamin D-dependent calcium-binding protein in adipocyte
8) Confidence 0.33 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
They contained striatum-like patches with neurons expressing many of the neurochemicals characteristic of striatum (ACh, ChAT, calbindin-D28KD, met-enkephalin, and dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein-32,000 or DARPP-32), and these patches were surrounded by graft tissue expressing few of these striatal markers.
Gene_expression (expressing) of calbindin-D28KD in neurons associated with adenocard, dopamine and enkephalin
9) Confidence 0.13 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1279138 Disease Relevance 0 Pain Relevance 0.28
They contained striatum-like patches with neurons expressing many of the neurochemicals characteristic of striatum (ACh, ChAT, calbindin-D28KD, met-enkephalin, and dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein-32,000 or DARPP-32), and these patches were surrounded by graft tissue expressing few of these striatal markers.
Gene_expression (expressing) of calbindin-D28KD in neurons associated with adenocard, dopamine and enkephalin
10) Confidence 0.13 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1279138 Disease Relevance 0 Pain Relevance 0.28
The calbindin gene, abundantly expressed in dentate gyrus (DG) granule cells, and to some extent also in CA1 pyramidal neurons [22], [39], was now down-regulated.
Gene_expression (expressed) of calbindin gene in pyramidal neurons associated with pyramidal cell
11) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.73 Pain Relevance 0.08
VPRs can specifically be visualized by protein gene product 9.5 immunostaining, and were shown to express vesicular glutamate transporters, calbindin D28K, Na+/K+-ATPase, and P2X3 ATP-receptors.
Gene_expression (express) of D28K (D28K) associated with glutamate
12) Confidence 0.08 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17170382 Disease Relevance 0.13 Pain Relevance 0.11
The hypocalciu</span>ric effect of hydrochlorothiazide (HCTZ) and the expression of transient receptor potential vanilloid 5 (TRPV5), calbindin-D28K, and several sodium transporters were assessed in hypercalciuric rats induced by high calcium diet and vitamin D3.
Gene_expression (expression) of calbindin-D28K (D28K)
13) Confidence 0.08 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923802 Disease Relevance 0.10 Pain Relevance 0
Expression of TRPV5 and calbindin-D28K mRNA significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered (Figs. 3, 4).
Gene_expression (Expression) of calbindin-D28K mRNA (D28K)
14) Confidence 0.08 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0
To assess the effect of thiazides on the transporters participating in the passive and active calcium reabsorption under severe hypercalciuric condition, the expression of NHE3 and SGLT1 on the PT, NKCC2 on the TAL, and TRPV5 and calbindin-D28K on the DCT was analyzed.


Spec (analyzed) Gene_expression (expression) of calbindin-D28K (D28K)
15) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.33 Pain Relevance 0
These authors also acknowledged some arguments that speak for a non-neuronal function of microvillar cells, but pointed out that the peroxidase backfill experiments [143] and the expression of Spot-35 protein [147] are in favour of positioning microvillar cells "in with known microvillar olfactory receptor cells of other vertebrates".
Gene_expression (expression) of Spot-35 in olfactory receptor cells
16) Confidence 0.02 Published 2007 Journal BMC Neuroscience Section Body Doc Link PMC1995455 Disease Relevance 0 Pain Relevance 0
Moreover, the cells express neuronal marker protein MAP2b [148], Ca2+-binding protein SPOT-35 [153], and they are depolarized by high potassium chloride [148].
Gene_expression (express) of SPOT-35 in neuronal
17) Confidence 0.02 Published 2007 Journal BMC Neuroscience Section Body Doc Link PMC1995455 Disease Relevance 0 Pain Relevance 0
Apparently, there is a developmental reduction in Calbindin-D28k expression parallel to RHT formation and a developmental increase in calretinin expression which is independent of RHT connections to SCN neurons [250].


Gene_expression (expression) of Calbindin-D28k in neurons
18) Confidence 0.01 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.04

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