INT47391

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 12.31
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
PAF 2
liver 1
spinal cord 1
vas deferens 1
Paf (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 94 100.00 Very High Very High Very High
antagonist 44 99.96 Very High Very High Very High
Multiple sclerosis 411 99.84 Very High Very High Very High
Spinal cord 12 99.68 Very High Very High Very High
agonist 51 99.36 Very High Very High Very High
chemokine 181 99.16 Very High Very High Very High
Inflammatory mediators 22 98.28 Very High Very High Very High
Inflammation 288 97.82 Very High Very High Very High
Potency 10 96.16 Very High Very High Very High
cytokine 155 91.60 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 95 100.00 Very High Very High Very High
Adhesions 43 100.00 Very High Very High Very High
Multiple Sclerosis 465 99.96 Very High Very High Very High
Sepsis 68 99.50 Very High Very High Very High
Thrombocytopenia 27 99.28 Very High Very High Very High
Disorder Of Lipid Metabolism 139 99.04 Very High Very High Very High
Asthma 5 99.04 Very High Very High Very High
Atherosclerosis 12 98.78 Very High Very High Very High
Disease 187 98.28 Very High Very High Very High
INFLAMMATION 339 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Verapamil, 0.03-0.3 mg/Kg, also increased PAF, VR, and RAP to the lesser extent than perhexiline.
Positive_regulation (increased) of PAF in PAF
1) Confidence 0.62 Published 1981 Journal Jpn Heart J Section Abstract Doc Link 7339008 Disease Relevance 0 Pain Relevance 0
It is concluded that the effect of perhexiline to increase VR and PAF is in most part mediated through the cardiovascular reflex control for blood pressure reduction by the drug, though a direct effect on capacitance vessels may be included.
Positive_regulation (increase) of PAF in vessels
2) Confidence 0.62 Published 1981 Journal Jpn Heart J Section Abstract Doc Link 7339008 Disease Relevance 0 Pain Relevance 0
Perhexiline, 0.3-3 mg/Kg, injected intravenously over 2 min caused dose-dependent increases in PAF, VR, and RAP, followed by decreases in PAF and VR at higher doses.
Positive_regulation (increases) of PAF in PAF
3) Confidence 0.54 Published 1981 Journal Jpn Heart J Section Abstract Doc Link 7339008 Disease Relevance 0 Pain Relevance 0
In the present study (part II), we examine the response of the mouse vas deferens (MVD), which is populated with the delta receptor subtype, to increasing concentrations of PAF from the white-tailed prairie dog (WT) and the black-tailed prairie dog (BT).
Spec (examine) Positive_regulation (increasing) of PAF in vas deferens
4) Confidence 0.54 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9329050 Disease Relevance 0 Pain Relevance 0.30
Although septic animal models exhibit beneficial effects as a result of PAF antagonist treatment, clinical studies on patients with sepsis do not display similar outcome.
Positive_regulation (result) of PAF associated with antagonist and sepsis
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 1.17 Pain Relevance 0.44
Interestingly, histological examination of liver and lung sections showed that PMN accumulation in PAF-administrated mice were significantly lower than those in LPS-challenged mice.
Positive_regulation (accumulation) of PAF in lung
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.83 Pain Relevance 0.07
Such a decrease of PAF-AH activity may in part be responsible for the reported increase of PAF in MS plasma and CSF, and therefore could contribute to the inflammation and vascular permeability changes seen in the CNS of MS.
Positive_regulation (increase) of PAF in plasma associated with multiple sclerosis and inflammation
7) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.03 Pain Relevance 0.52
Elevation of PAF in the CSF and plasma of RRMS patients was reported, and the authors concluded that PAF is likely responsible for the early disruption of the BBB in MS [193].
Positive_regulation (Elevation) of PAF in plasma associated with multiple sclerosis
8) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.61 Pain Relevance 0.27
Interestingly, histological examination of liver and lung sections showed that PMN accumulation in PAF-administrated mice were significantly lower than those in LPS-challenged mice.
Positive_regulation (accumulation) of PAF in liver
9) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.83 Pain Relevance 0.07
In earlier work, Callea et al reported 6-fold elevated PAF in the plasma of human RRMS patients and 15-fold elevation above controls in CSF [193].
Positive_regulation (elevated) of PAF in plasma
10) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.12 Pain Relevance 0.25
PAF may be released from DRG neurons and then activates PAFR expressed in macrophages.
Positive_regulation (activates) of PAF in neurons associated with dorsal root ganglion
11) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.13 Pain Relevance 0.77
HDL inhibit agonist-induced production of platelet-activating factor (PAF), a bioactive phospholipid that stimulates cell adhesion, platelet aggregation, and vascular permeability in endothelial cells (Sugatani et al 1996).
Positive_regulation (activating) of PAF in endothelial cells associated with agonist, adhesions and disorder of lipid metabolism
12) Confidence 0.11 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.32 Pain Relevance 0.05
Humm et al observed such differences in responses to prednisone [316]; and PAF activity was higher in RRMS than in secondary progressive MS [193]; and stronger differences were observed in sP-Selectin and other markers in RRMS compared to secondary progressive [311].
Positive_regulation (higher) of PAF associated with multiple sclerosis
13) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.76 Pain Relevance 0.38
In EAE, elevated PAF in the spinal cord, which was not the result of reduced PAF-AH activity, appeared to be caused by cytosolic PLA2 activity [177].
Positive_regulation (elevated) of PAF in spinal cord associated with multiple sclerosis and spinal cord
14) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.33 Pain Relevance 0.16
PAF (platelet activation factor), IL8 and leukocyte adhesion molecules (ICAM-1, VCAM) are required for the recruitment and activation of leukocytes in the interstitium [6,13,14,97,98].
Positive_regulation (required) of PAF in leukocytes associated with adhesions
15) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 1.10 Pain Relevance 0.35
Recent reports suggested that serum PAF-AH might play an anti-inflammatory role in human diseases, such as atherosclerosis [26], asthma [27], and septic shock [28], by preventing the accumulation of PAF and PAF-like oxidized phospholipids.
Positive_regulation (accumulation) of PAF associated with asthma, inflammation, atherosclerosis, disease and sepsis
16) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.04 Pain Relevance 0.08
Recent reports suggested that serum PAF-AH might play an anti-inflammatory role in human diseases, such as atherosclerosis [26], asthma [27], and septic shock [28], by preventing the accumulation of PAF and PAF-like oxidized phospholipids.
Positive_regulation (accumulation) of PAF associated with asthma, inflammation, atherosclerosis, disease and sepsis
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 1.04 Pain Relevance 0.08

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