INT4742

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2010
Negated 12
Speculated 8
Reported most in Abstract
Documents 177
Total Number 186
Disease Relevance 69.99
Pain Relevance 102.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 28
dorsal horn 7
striatum 6
mast cells 6
lymphocytes 4
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 1413 100.00 Very High Very High Very High
Neuropeptide 421 100.00 Very High Very High Very High
antagonist 406 100.00 Very High Very High Very High
Enkephalin 239 100.00 Very High Very High Very High
Glutamate 180 100.00 Very High Very High Very High
agonist 165 100.00 Very High Very High Very High
nMDA receptor 114 100.00 Very High Very High Very High
opioid receptor 84 100.00 Very High Very High Very High
gABA 46 100.00 Very High Very High Very High
Opioid 37 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 594 100.00 Very High Very High Very High
Nociception 683 99.84 Very High Very High Very High
Parkinson's Disease 20 99.84 Very High Very High Very High
Anaplastic Astrocytoma 5 99.84 Very High Very High Very High
Nervous System Injury 145 99.70 Very High Very High Very High
Hyperaesthesia 5 99.70 Very High Very High Very High
Respiratory Syncytial Virus 81 99.68 Very High Very High Very High
Aids-related Complex 1572 99.64 Very High Very High Very High
Pain 537 99.62 Very High Very High Very High
INFLAMMATION 957 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system.
Gene_expression (expressed) of neurokinin-1 in central nervous system associated with pain, neurotransmitter, central nervous system and substance p
1) Confidence 0.78 Published 1998 Journal Nature Section Abstract Doc Link 9537323 Disease Relevance 0.48 Pain Relevance 0.83
On the other hand, there were no significant differences in NK1-like immunoreactivity, [(3)H]substance P binding, or NK1 gene expression in the dorsal horn of the spinal cord between NOP(-/-) and NOP(+/+) mice.
Gene_expression (expression) of NK1 in spinal cord associated with dorsal horn, spinal cord and substance p
2) Confidence 0.77 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12606680 Disease Relevance 0.68 Pain Relevance 1.18
Neurokinin-1 receptor gene expression in the mouse dorsal horn increases with neuropathic pain.
Gene_expression (expression) of Neurokinin-1 receptor in dorsal horn associated with neuralgia, neuropathic pain and dorsal horn
3) Confidence 0.77 Published 2004 Journal J Pain Section Title Doc Link 15042514 Disease Relevance 0.70 Pain Relevance 0.93
Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1 receptor (NK-1) expression in the dorsal horn of the spinal cord.
Gene_expression (expression) of neurokinin-1 receptor in Peripheral nerve associated with hyperesthesia, nervous system injury, dorsal horn, spinal cord and peripheral nerve injury
4) Confidence 0.77 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.42 Pain Relevance 0.64
To test the hypothesis that NK-1 gene expression underlies these responses, we used solution hybridization-nuclease protection assays to quantify NK-1 mRNA levels in dorsal quadrants of the mouse lumbar dorsal horn.
Gene_expression (expression) of NK-1 gene in dorsal horn associated with dorsal horn
5) Confidence 0.77 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.53 Pain Relevance 0.67
Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1 receptor (NK-1) expression in the dorsal horn of the spinal cord.
Gene_expression (expression) of NK-1 in Peripheral nerve associated with hyperesthesia, nervous system injury, dorsal horn, spinal cord and peripheral nerve injury
6) Confidence 0.77 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.42 Pain Relevance 0.64
Loss of NK1 receptor-expressing neurons in the amygdala caused an increase in anxiety-like behavior on the EPM.
Gene_expression (expressing) of NK1 in neurons associated with anxiety disorder and amygdala
7) Confidence 0.77 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12967989 Disease Relevance 0.33 Pain Relevance 1.14
To identify the areas of the brain that might contribute to this effect, we assessed the behavioral effects of ablation of neurons expressing the NK1 receptor in specific regions of the mouse brain using the neurotoxin substance P-saporin.
Gene_expression (expressing) of NK1 in neurons associated with substance p
8) Confidence 0.77 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12967989 Disease Relevance 0.20 Pain Relevance 0.68
Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse.
Gene_expression (expressing) of Neurokinin-1 in amygdala associated with anxiety disorder, amygdala and morphine
9) Confidence 0.77 Published 2003 Journal J. Neurosci. Section Title Doc Link 12967989 Disease Relevance 0.23 Pain Relevance 0.83
NK1 receptor-expressing neurons in the mouse amygdala therefore modulate morphine reward behaviors.
Gene_expression (expressing) of NK1 in neurons associated with amygdala and morphine
10) Confidence 0.77 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12967989 Disease Relevance 0.34 Pain Relevance 1.17
We examined PPE and PPT (preprotachykinin) gene expression in striatal projection neurons and in striatal projection fibers immunoreactive for the PPE product enkephalin (ENK) and the PPT product substance P (SP) in a transgenic HD model, the R6/2 mouse, to see if changes occur in these neuron types similar to those seen in early adult-onset HD.
Gene_expression (expression) of PPT in projection neurons associated with targeted disruption, enkephalin, projection neuron, disease and substance p
11) Confidence 0.76 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586547 Disease Relevance 0.61 Pain Relevance 0.54
The dendritic geometry and synaptic input of the large LI neurones that receive input from primary afferents containing substance P that express neurokinin 1 (NK(1)) receptors suggests that these neurones may monitor the extent of injury rather than the specific localisation of a discrete noxious stimulus.
Gene_expression (express) of neurokinin 1 associated with injury and substance p
12) Confidence 0.75 Published 2004 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15464206 Disease Relevance 0.73 Pain Relevance 0.43
EtOH, capsaicin, and SP stimulated generation of ROS by superficial gastric epithelial cells expressing neurokinin 1 receptors by a neurokinin 1 receptor-dependent mechanism.
Gene_expression (expressing) of neurokinin 1 in epithelial cells associated with qutenza and substance p
13) Confidence 0.75 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17640568 Disease Relevance 0.07 Pain Relevance 0.56
The nociceptive function of SP is mainly attributed to the activation of NK1 receptors (NK1R) that are expressed on nociceptive projection neurons located in lamina I of the dorsal horn [8,11,12].
Gene_expression (expressed) of NK1 in lamina associated with nociception, dorsal horn, projection neuron and substance p
14) Confidence 0.75 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.59 Pain Relevance 1.01
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Gene_expression (expression) of Tac1 associated with calcitonin gene related peptide, neuropeptide and substance p
15) Confidence 0.75 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 1.10
mediates the inhibitory effect of E2 (after 24 h) on Tac1 expression.
Gene_expression (expression) of Tac1
16) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.15
The importance of NK-1 signaling and TRPV1 expressing afferent nerves for disease development was studied in recipient SCID mice systemically treated with either high-affinity NK-1 receptor antagonists or neurotoxic doses of capsaicin.
Gene_expression (expressing) of NK-1 in nerves
17) Confidence 0.74 Published 2009 Journal Inflamm. Bowel Dis. Section Body Doc Link 19326358 Disease Relevance 0.10 Pain Relevance 0
The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system.
Gene_expression (expressed) of NK-1 in central nervous system associated with pain, neurotransmitter, central nervous system and substance p
18) Confidence 0.68 Published 1998 Journal Nature Section Abstract Doc Link 9537323 Disease Relevance 0.48 Pain Relevance 0.83
XX mice had higher expression, relative to XY mice of the same gonadal sex, of Pdyn and Tac1 mRNA in specific striatal regions.
Gene_expression (expression) of Tac1 in gonadal
19) Confidence 0.67 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19250439 Disease Relevance 0 Pain Relevance 0.18
Mice lacking the neurokinin-1 (NK1) receptor, the preferred receptor for the neuropeptide substance P (SP), do not show many of the behaviors associated with morphine reward.
Neg (lacking) Gene_expression (lacking) of NK1 associated with neuropeptide, morphine and substance p
20) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12967989 Disease Relevance 0.07 Pain Relevance 0.51

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