INT47434

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Context Info
Confidence 0.60
First Reported 1980
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.40
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Tnnt2) cytoplasm (Tnnt2)
Anatomy Link Frequency
cardiac muscle 1
Skeletal muscle 1
Tnnt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 99.48 Very High Very High Very High
Angina 22 95.24 Very High Very High Very High
anesthesia 2 84.00 Quite High
Pain 5 83.32 Quite High
ischemia 15 81.52 Quite High
Inflammation 22 74.48 Quite High
imagery 31 68.40 Quite High
anticonvulsant 1 29.36 Quite Low
cytokine 4 21.36 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 42 100.00 Very High Very High Very High
Congenital Anomalies 7 99.96 Very High Very High Very High
Reye's Syndrome 2 99.76 Very High Very High Very High
Disease 123 99.68 Very High Very High Very High
Myocardial Infarction 219 99.28 Very High Very High Very High
Muscle Disease 5 99.20 Very High Very High Very High
Chronic Renal Failure 26 98.64 Very High Very High Very High
Death 10 98.62 Very High Very High Very High
Targeted Disruption 8 98.16 Very High Very High Very High
Angina 16 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified an HCM-causative mutation in one of the five most commonly mutated sarcomeric genes (MYH7, MYBPC3, TPM1, TNNI3, or TNNT2) in 40 cases, but we cannot exclude that other patients harbour mutations in any of the other genes that have been linked to HCM.
Gene_expression (identified) of TNNT2 associated with hypertrophic cardiomyopathy
1) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.44 Pain Relevance 0.05
CONCLUSION: We conclude that elevated TnT levels in the postoperative period confer a 15-fold increase in mortality during the first year after surgery.
Gene_expression (levels) of TnT
2) Confidence 0.60 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15352951 Disease Relevance 0 Pain Relevance 0
An increase in the rate of cardiac death or myocardial infarction was seen during follow-up, with increasing levels of TnT.
Gene_expression (levels) of TnT associated with myocardial infarction and death
3) Confidence 0.53 Published 1998 Journal Eur. Heart J. Section Abstract Doc Link 9857941 Disease Relevance 0.57 Pain Relevance 0.09
If CK-MB and TnT were negative, the early adverse event rate was 27%.
Neg (negative) Gene_expression (negative) of TnT
4) Confidence 0.51 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10728944 Disease Relevance 0.66 Pain Relevance 0.15
The effect of MBNL1 loss of function is reflected in Mbnl1 knockout mice that exhibit Skeletal muscle-specific chloride channel 1 (Clcn1), Cardiac troponin T (Tnnt2) and Skeletal troponin T (Tnnt3) splicing abnormalities characteristic of DM1 [16].
Gene_expression (splicing) of Tnnt2 in Skeletal muscle associated with targeted disruption and congenital anomalies
5) Confidence 0.51 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.44 Pain Relevance 0
TnT (at 0.1 ng/ml) and CK-MB were positive in a similar proportion of patients (20.4% and 19.7%, respectively); however, the patients identified by TnT and CK-MB were not identical.
Gene_expression (positive) of TnT
6) Confidence 0.40 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10728944 Disease Relevance 0.77 Pain Relevance 0.18
If the first ECG, CK-MB mass and TnT are all negative, the probability of having an AMI is 12%.
Neg (negative) Gene_expression (negative) of TnT associated with myocardial infarction
7) Confidence 0.24 Published 2000 Journal Eur J Emerg Med Section Abstract Doc Link 11132084 Disease Relevance 1.01 Pain Relevance 0.45
Preoperative serum levels of TnT and TnI were similar.
Gene_expression (levels) of TnT
8) Confidence 0.16 Published 2003 Journal Interact Cardiovasc Thorac Surg Section Abstract Doc Link 17670055 Disease Relevance 0 Pain Relevance 0.08
However, there are few studies describing the significance and the prognostic value of elevated serum cTnT levels in stable patients with moderate CKD [70].
Gene_expression (levels) of cTnT associated with chronic renal failure
9) Confidence 0.13 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.89 Pain Relevance 0.10
In a multivariable model, elevated levels of TnT (HR, 1.83; 95% CI, 1.05-3.86; P =.03), sCD40L (HR, 2.65; 95% CI, 1.41-4.99; P =.002), and PlGF (HR, 3.03; 95% CI, 1.54-5.95; P<.001) were independent predictors, while elevated hsCRP level was not (HR, 0.98; 95% CI, 0.53-1.98; P =.94).
Gene_expression (levels) of TnT
10) Confidence 0.08 Published 2004 Journal JAMA Section Body Doc Link 14747500 Disease Relevance 0.06 Pain Relevance 0
The highest TnT levels were observed in cardiovascular group and the lowest TnT levels in non-disease group among the patient groups.
Gene_expression (levels) of TnT associated with disease
11) Confidence 0.06 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274989 Disease Relevance 1.34 Pain Relevance 0.07
The highest TnT levels were observed in cardiovascular group and the lowest TnT levels in non-disease group among the patient groups.
Gene_expression (levels) of TnT associated with disease
12) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274989 Disease Relevance 1.30 Pain Relevance 0.07
Serum TnT values in patients with AMI showed positive correlations with NT-proBNP (r = 0.28, p<0.01), CK-MB (r = 0.31, p<0.01) and MDA (r = 0.23, p<0.01) (Table 3).
Gene_expression (values) of TnT associated with myocardial infarction
13) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274989 Disease Relevance 1.68 Pain Relevance 0
The cardiac muscle isoenzyme was detected in the serum of 17 myopathy patients.
Gene_expression (detected) of cardiac muscle isoenzyme in cardiac muscle associated with muscle disease
14) Confidence 0.01 Published 1980 Journal J. Pediatr. Section Abstract Doc Link 7359257 Disease Relevance 1.23 Pain Relevance 0.12

General Comments

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