INT47443

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Context Info
Confidence 0.61
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.65
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
body 2
covering 1
lymph node 1
trachea 1
T cells 1
seb (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 5 99.04 Very High Very High Very High
Morphine 3 98.36 Very High Very High Very High
substance P 4 98.24 Very High Very High Very High
antagonist 24 93.88 High High
opiate 2 93.68 High High
Neuropeptide 8 92.48 High High
narcan 4 92.24 High High
MU agonist 3 92.24 High High
anesthesia 8 91.52 High High
5HT 2 91.40 High High
Disease Link Frequency Relevance Heat
Body Weight 8 99.00 Very High Very High Very High
Death 85 97.56 Very High Very High Very High
Shock 2 94.08 High High
Unconsciousness 1 92.24 High High
Bacillus Anthracis Infection 2 88.80 High High
Fever 3 87.84 High High
Hyperthyroidism 1 86.72 High High
Sepsis 4 76.84 Quite High
Cancer 11 75.00 Quite High
Necrosis 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intramuscular injection of staphylococcal enterotoxin B (SEB) at a dosage level of 50 microgram/kg of body weight caused death in Dutch rabbits.
Gene_expression (injection) of SEB in body associated with body weight and death
1) Confidence 0.61 Published 1980 Journal Am. J. Vet. Res. Section Abstract Doc Link 7369614 Disease Relevance 0.37 Pain Relevance 0.21
On the other hand, the production of IL-2 in response to lymph node T cell stimulation with SEB was not altered by the opioid treatment.
Gene_expression (production) of SEB in lymph node associated with opioid
2) Confidence 0.58 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9143250 Disease Relevance 0 Pain Relevance 0.68
Naltrexone significantly inhibited the production of TNF-alpha induced by LPS, but not SEB in vivo.
Gene_expression (production) of SEB
3) Confidence 0.58 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15265541 Disease Relevance 0.86 Pain Relevance 0.66
SEB was injected IT at a dose of 1 mg/kg body weight in a total volume of 50 ?
Gene_expression (injected) of SEB in body associated with body weight
4) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.63 Pain Relevance 0.26
These discrepancies might be due to differences in the regimes of SEB injection.
Gene_expression (injection) of SEB
5) Confidence 0.39 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.44 Pain Relevance 0
Some studies showed that deletion of SEB-activated T cells in mice was in part FasL-Fas dependent (Mogil et al., 1995; Renno et al., 1996), whereas others found that Fas deficiency (in Faslpr/lpr mutant mice) had no impact but that loss of Bim provided profound protection (Hildeman et al., 2002).
Gene_expression (deletion) of SEB in T cells
6) Confidence 0.39 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.19 Pain Relevance 0
Using this protocol, 35 aM staphylococcal enterotoxin B (SEB) was detected in <20 min [28] with a log-linear dose response curve covering six orders of magnitude.
Gene_expression (detected) of SEB in covering
7) Confidence 0.13 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857369 Disease Relevance 0.17 Pain Relevance 0.20
Male Wistar rats were exposed intratracheally with SEA (3 ng/trachea) or SEB (250 ng/trachea).
Gene_expression (exposed) of SEB in trachea
8) Confidence 0.09 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19375418 Disease Relevance 0 Pain Relevance 0.22
The substance P and IL-1 levels in bronchoalveolar lavage fluid of SEA-exposed rats were significantly higher than SEB.
Gene_expression (higher) of SEB associated with substance p
9) Confidence 0.09 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19375418 Disease Relevance 0 Pain Relevance 0.45

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