INT47451

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Context Info
Confidence 0.35
First Reported 1980
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 10.07
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 3
kidney 3
sensory neurons 2
sensory nerves 2
mast cells 2
ras (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 12 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
nociceptor 3 100.00 Very High Very High Very High
qutenza 1 100.00 Very High Very High Very High
gABA 21 99.20 Very High Very High Very High
substance P 20 99.16 Very High Very High Very High
Neuropeptide 2 98.76 Very High Very High Very High
Paracetamol 24 98.16 Very High Very High Very High
chemokine 99 97.76 Very High Very High Very High
Analgesic 2 93.04 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 213 100.00 Very High Very High Very High
Watson Syndrome 122 100.00 Very High Very High Very High
Cv Unclassified Under Development 11 100.00 Very High Very High Very High
Obesity 10 98.48 Very High Very High Very High
Hepatotoxicity 4 98.32 Very High Very High Very High
Hypertension 65 97.94 Very High Very High Very High
Injury 9 96.92 Very High Very High Very High
Liver Failure 2 95.88 Very High Very High Very High
Targeted Disruption 23 95.44 Very High Very High Very High
Cancer 208 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To better understand the contributions of different signaling pathways, the expression and role of Ras activation was evaluated after oral dosing of mice with APAP (400-500 mg/kg).
Positive_regulation (role) of Positive_regulation (activation) of Ras associated with paracetamol
1) Confidence 0.35 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.44 Pain Relevance 0.58
CONCLUSION: This study identifies a key role for Ras activation and demonstrates the therapeutic efficacy of FTIs during APAP-induced liver injury.
Positive_regulation (role) of Positive_regulation (activation) of Ras in liver associated with paracetamol and injury
2) Confidence 0.35 Published 2009 Journal Hepatology Section Abstract Doc Link 19739265 Disease Relevance 0.64 Pain Relevance 0.76
Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.
Positive_regulation (induce) of Positive_regulation (Activation) of RAS
3) Confidence 0.21 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0 Pain Relevance 0
These mutant mice exhibit increased levels of activated Ras (Ras-GTP) and increased GABA mediated inhibition.
Positive_regulation (levels) of Positive_regulation (activated) of Ras associated with gaba
4) Confidence 0.20 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.33 Pain Relevance 0.26
These mutant mice exhibit increased levels of activated Ras (Ras-GTP) and increased GABA mediated inhibition.
Positive_regulation (increased) of Positive_regulation (activated) of Ras associated with gaba
5) Confidence 0.20 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.33 Pain Relevance 0.26
These mutant mice exhibit increased levels of activated Ras (Ras-GTP) and increased GABA mediated inhibition.
Positive_regulation (increased) of Positive_regulation (levels) of Ras associated with gaba
6) Confidence 0.20 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.33 Pain Relevance 0.26
In the liver and kidney as well (31–33), diabetes-induced activation of the RAS causes elevated concentration of tissue angiotensin II.
Positive_regulation (induced) of Positive_regulation (activation) of RAS in kidney associated with diabetes mellitus
7) Confidence 0.11 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.78 Pain Relevance 0
The tissue RAS activation in diabetes is explained in part by the findings that in vitro stimulation with high glucose enhanced the transcriptional activity of angiotensinogen gene encoding a precursor protein for angiotensin I and II (34,35).
Positive_regulation (enhanced) of Positive_regulation (activation) of RAS associated with diabetes mellitus
8) Confidence 0.11 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.71 Pain Relevance 0
Collectively, our findings indicate that an important link exists in the heart between sensory nerves and renin-containing mast cells; substance P released from sensory nerves plays a significant role in the release of mast cell renin in ischemia/reperfusion and in the activation of a local cardiac RAS.
Positive_regulation (role) of Positive_regulation (activation) of RAS in sensory nerves associated with ischemia and substance p
9) Confidence 0.08 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20668055 Disease Relevance 0.34 Pain Relevance 0.58
In ischemia/reperfusion, cardiac sensory nerves release neuropeptides such as substance P that, by degranulating mast cells, might promote renin release, thus activating a local RAS and ultimately inducing cardiac dysfunction.
Spec (might) Positive_regulation (promote) of Positive_regulation (activating) of RAS in mast cells associated with ischemia, neuropeptide and substance p
10) Confidence 0.08 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20668055 Disease Relevance 0.22 Pain Relevance 0.46
Apparently, activation of ERK1/2 by EGF stimulation was independent of increased RAS-GTP levels.
Neg (independent) Positive_regulation (independent) of Positive_regulation (increased) of RAS
11) Confidence 0.07 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.87 Pain Relevance 0
Increased levels of RAS-GTP have previously been shown in MPNSTs from NF1 patients [29-31], caused perhaps by loss of the RAS-GAP-function of the NF1 gene product, neurofibromin.
Positive_regulation (caused) of Positive_regulation (Increased) of RAS associated with watson syndrome
12) Confidence 0.06 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 1.33 Pain Relevance 0
subunits, inhibition of adenylyl cyclase activity, increased generation of inositol trisphosphate, intracellular calcium release, and the activation of phosphatidyl inositol 3 kinase (PI3K)/Akt cascade and Ras/MAP kinase signalling [3].
Positive_regulation (increased) of Positive_regulation (activation) of Ras
13) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.22 Pain Relevance 0.40
Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors.
Positive_regulation (necessary) of Positive_regulation (Activation) of Ras in sensory neurons associated with qutenza
14) Confidence 0.04 Published 2003 Journal Mol. Cell. Neurosci. Section Title Doc Link 12595244 Disease Relevance 0.26 Pain Relevance 0.76
In the liver and kidney as well (31–33), diabetes-induced activation of the RAS causes elevated concentration of tissue angiotensin II.
Positive_regulation (induced) of in liver Positive_regulation (activation) of RAS in kidney associated with diabetes mellitus
15) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.78 Pain Relevance 0
Obesity is another common comorbidity in hypertensive patients.42 Current hypertension treatment guidelines do not provide specific guidance for hypertension in the presence of obesity, although its peculiar pathophysiologic characteristics (volume expansion, increased cardiac output, and RAS activation) make thiazide diuretics and RAS inhibitors suitable treatment options.
Positive_regulation (increased) of Positive_regulation (activation) of RAS associated with hypertension and obesity
16) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 1.33 Pain Relevance 0
Signaling through this pathway is often initiated by activation of membrane-localized receptors, leading to activation of the GTPase Ras, and subsequent activation of the MAPK kinase kinase Raf, the MAPK kinases MEK1/2 and the MAPKs Erk1/2 [11].
Positive_regulation (leading) of Positive_regulation (activation) of Ras
17) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.98 Pain Relevance 0.24
A high level of RAS activity is necessary for optimal blockade by an ACE inhibitor or an ARB.
Positive_regulation (necessary) of Positive_regulation (level) of RAS
18) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663442 Disease Relevance 0.16 Pain Relevance 0.04
1 was strongly dependent on the activation of Ras and Raf-1 since transfection with dominant-negative forms of these proteins completely inhibited the stimulating effect of TGF-?
Positive_regulation (dependent) of Positive_regulation (activation) of Ras
19) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0

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