INT47453

Context Info Confidence 0.31 First Reported 1980 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.17 Pain Relevance 0.32

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency cardiovascular system 4 plasma 2 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat noradrenaline 2 99.80 Serotonin 1 82.00 Kinase C 20 77.48 antagonist 14 58.96 Bioavailability 10 51.80 cva 6 46.16 aspirin 2 43.80 anesthesia 1 25.00 qutenza 1 25.00 Inflammation 10 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 54 99.24 Stress 32 85.72 Hypertrophy 4 75.00 Renal Disease 8 71.04 Hyperglycemia 18 60.00 Aging 12 58.80 Pressure And Volume Under Development 37 58.36 Hyperlipidemia 22 57.80 Diabetes Mellitus 58 56.92 Cv General 3 Under Development 6 46.16

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.

Positive_regulation (induce) of Positive_regulation (Activation) of AII

1) Confidence 0.31 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0 Pain Relevance 0

AII infusion resulted in a significant elevation in mean arterial pressure and in plasma AII and noradrenaline levels.

Positive_regulation (resulted) of Positive_regulation (elevation) of AII in plasma associated with noradrenaline

2) Confidence 0.12 Published 1997 Journal J. Vasc. Res. Section Abstract Doc Link 9256089 Disease Relevance 0.07 Pain Relevance 0.13

In these effects an activated ET is likely to mediate the activity of the AII through NOX activation as AII-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NOX.66 The mitochondrial ROS is responsible to mediate the activity of ET-1 in the cardiovascular system.67 The vascular activity of AII is closely related to ET-1, coronary vasoconstriction by ?

Positive_regulation (vascular) of Positive_regulation (activity) of AII in cardiovascular system associated with increased venous pressure under development

3) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.55 Pain Relevance 0.09

In these effects an activated ET is likely to mediate the activity of the AII through NOX activation as AII-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NOX.66 The mitochondrial ROS is responsible to mediate the activity of ET-1 in the cardiovascular system.67 The vascular activity of AII is closely related to ET-1, coronary vasoconstriction by ?

Positive_regulation (related) of Positive_regulation (activity) of AII in cardiovascular system associated with increased venous pressure under development

4) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.55 Pain Relevance 0.09

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