INT47495

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Context Info
Confidence 0.98
First Reported 1980
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.68
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 22 98.72 Very High Very High Very High
agonist 2 96.28 Very High Very High Very High
Pain 1 92.24 High High
tolerance 1 56.36 Quite High
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 1 96.00 Very High Very High Very High
Reprotox - General 1 1 94.12 High High
Hypertension 1 93.60 High High
Arthralgia 1 92.24 High High
Acromegaly 3 91.28 High High
Impaired Glucose Tolerance 1 56.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A specific action of bromocriptine on the degradation rate of 'little' GH may result in a selective reduction of the bioactive monomeric component of GH and may explain the discrepancy between the clinical and the biochemical response to bromocriptine.
Protein_catabolism (degradation) of GH
1) Confidence 0.98 Published 1980 Journal Horm. Res. Section Abstract Doc Link 7390405 Disease Relevance 0.68 Pain Relevance 0.12
The short- and long-term stability of plasma growth hormone (GH) and plasma 3-methoxy-4-hydroxy phenylglycol (MHPG) responses to clonidine (2 micrograms/kg IV) over a 60-min period were assessed in subsets of 13 male normal controls on 2 consecutive days (Study A; n = 11) and on 2 days separated by several months (Study B; n = 11).
Protein_catabolism (stability) of growth hormone in plasma associated with clonidine
2) Confidence 0.49 Published 1994 Journal Psychoneuroendocrinology Section Abstract Doc Link 9210208 Disease Relevance 0 Pain Relevance 0.38
The stability of plasma growth hormone and MHPG responses to repeated clonidine challenge in normal males.
Protein_catabolism (stability) of growth hormone in plasma associated with clonidine
3) Confidence 0.49 Published 1994 Journal Psychoneuroendocrinology Section Title Doc Link 9210208 Disease Relevance 0 Pain Relevance 0.58

General Comments

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