INT475

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 7.87
Pain Relevance 9.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra1a) aging (Adra1a) plasma membrane (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
plasma 2
neurons 2
pancreatic islets 1
thyroids 1
brain 1
Adra1a (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 10 100.00 Very High Very High Very High
Dismenorea 1 99.92 Very High Very High Very High
antinociception 4 99.62 Very High Very High Very High
Pain 21 99.54 Very High Very High Very High
Clonidine 31 99.14 Very High Very High Very High
isoflurane 3 99.12 Very High Very High Very High
narcan 20 99.02 Very High Very High Very High
noradrenaline 14 98.84 Very High Very High Very High
Angina 5 98.80 Very High Very High Very High
qutenza 13 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 1 99.92 Very High Very High Very High
Malignant Neoplastic Disease 1 99.92 Very High Very High Very High
Hypersensitivity 1 99.56 Very High Very High Very High
Syndrome 6 99.28 Very High Very High Very High
Hypertension 14 99.14 Very High Very High Very High
Pain 17 98.96 Very High Very High Very High
Cv General 3 Under Development 2 98.80 Very High Very High Very High
Increased Venous Pressure Under Development 7 98.72 Very High Very High Very High
Cv Unclassified Under Development 2 98.48 Very High Very High Very High
Antisocial Personality Disorder 9 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desensitization of alpha 1 adrenergic receptor induced by continuous high plasma norepinephrine concentration, was considered to decrease vascular resistance.
Negative_regulation (Desensitization) of alpha 1 adrenergic receptor in plasma
1) Confidence 0.58 Published 1994 Journal Masui Section Abstract Doc Link 8189622 Disease Relevance 0.70 Pain Relevance 0.09
Regional vascular responses varied, with naloxone demonstrating a vasoconstrictive effect despite alpha-adrenergic receptor blockade in some beds, and no effect in others.
Negative_regulation (blockade) of alpha-adrenergic receptor associated with narcan
2) Confidence 0.57 Published 1997 Journal Shock Section Abstract Doc Link 9068089 Disease Relevance 0.22 Pain Relevance 0.49
To examine the mechanism of the alpha 1-adrenoceptor-mediated inhibition of the release of thyroid hormones in the mouse thyroid, the effect of noradrenaline on the production of inositol phosphates was investigated using thyroids preloaded with [3H]inositol.
Spec (examine) Negative_regulation (inhibition) of alpha 1-adrenoceptor-mediated in thyroids associated with noradrenaline
3) Confidence 0.43 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 2830361 Disease Relevance 0 Pain Relevance 0.25
These behavioural, pharmacological and biochemical observations indicate that B-HT 958 possesses central alpha-adrenoceptor blocking activity and exerts a strong agonistic effect on brain dopamine autoreceptors.
Negative_regulation (blocking) of alpha-adrenoceptor in brain associated with dopamine
4) Confidence 0.42 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6152218 Disease Relevance 0.06 Pain Relevance 0.46
However, analysis of the effects of psychostimulants after either destruction of noradrenergic neurons or pharmacological blockade of alpha1-adrenergic receptors led to conflicting results.
Negative_regulation (blockade) of alpha1-adrenergic in neurons
5) Confidence 0.42 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11923452 Disease Relevance 0.18 Pain Relevance 0.43
Use of phentolamine, an alpha-adrenergic receptor inhibitor, in a diagnostic test may provide a more specific method for recognizing RSDS.
Negative_regulation (inhibitor) of alpha-adrenergic receptor associated with rsd
6) Confidence 0.42 Published 1994 Journal Curr Opin Rheumatol Section Abstract Doc Link 8024969 Disease Relevance 0.62 Pain Relevance 0.67
This increase was most pronounced in the plasma catecholamines is due to a reaction of the sympathetic nervous system to the alpha-adrenergic receptor blocking activity of droperidol causing vasodilation.
Negative_regulation (blocking) of alpha-adrenergic receptor in sympathetic nervous system associated with catecholamine and increased venous pressure under development
7) Confidence 0.41 Published 1981 Journal Clin Cardiol Section Abstract Doc Link 7307360 Disease Relevance 1.04 Pain Relevance 0.44
We sought to test the response of the coronary microcirculation to alpha-adrenoceptor blockade in patients with syndrome X (angina, ischemia-like stress electrocardiogram, and a normal coronary arteriogram).
Negative_regulation (blockade) of alpha-adrenoceptor associated with stress, angina, syndrome and ischemia
8) Confidence 0.41 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10511131 Disease Relevance 0.55 Pain Relevance 0.18
When the dose-response relationship of clonidine-induced antinociception was studied after alpha-1 receptor blockade by means of phenoxybenzamine, it was found that this effect comprised contributions from different neurotransmitter systems.
Negative_regulation (blockade) of alpha-1 receptor associated with antinociception, neurotransmitter and clonidine
9) Confidence 0.41 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6292401 Disease Relevance 0.17 Pain Relevance 1.17
In alpha-2C knockout mice with sulprostone-induced allodynia, blockade of clonidine's alpha-1 receptor agonist activity restored clonidine's analgesic efficacy.
Negative_regulation (blockade) of alpha-1 receptor
10) Confidence 0.38 Published 2009 Journal Anesthesiology Section Body Doc Link 19194166 Disease Relevance 0 Pain Relevance 0
Alpha-adrenergic receptor blockade and beta-adrenergic receptor blockade in the preoperative period was discussed.
Negative_regulation (blockade) of Alpha-adrenergic receptor
11) Confidence 0.19 Published 1979 Journal Can Anaesth Soc J Section Abstract Doc Link 41626 Disease Relevance 0.55 Pain Relevance 0.07
These responses were diminished by alpha-adrenergic receptor blockade.
Negative_regulation (blockade) of alpha-adrenergic receptor
12) Confidence 0.19 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474557 Disease Relevance 0.16 Pain Relevance 0
Plasma norepinephrine and epinephrine levels did not differ between Cap- and Veh-treated animals, whereas the increase in plasma insulin levels normally induced by alpha-adrenoceptor blockade by phentolamine was absent after Cap treatment.
Negative_regulation (blockade) of alpha-adrenoceptor in plasma associated with qutenza
13) Confidence 0.16 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943418 Disease Relevance 0.23 Pain Relevance 0.99
Smaller doses of yohimbine or atipamezole slightly increased (by 10%) the MAC of isoflurane, an increase we interpret as the result of blockade of a small amount of tonically active alpha-adrenoreceptor activity.
Negative_regulation (blockade) of alpha-adrenoreceptor associated with isoflurane
14) Confidence 0.13 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12760992 Disease Relevance 0 Pain Relevance 0.30
The greatest resistance to alpha-adrenoceptor blockade was seen at low frequencies.
Negative_regulation (blockade) of alpha-adrenoceptor
15) Confidence 0.13 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3709657 Disease Relevance 0 Pain Relevance 0.31
Monitoring adequacy of alpha-adrenoceptor blockade following systemic phentolamine administration.
Negative_regulation (blockade) of alpha-adrenoceptor associated with pain
16) Confidence 0.13 Published 1996 Journal Pain Section Title Doc Link 8867263 Disease Relevance 0.26 Pain Relevance 0.36
The dose of phentolamine to produce adequate blockade of peripheral alpha-adrenoceptor function has, however, not been previously determined.
Negative_regulation (blockade) of alpha-adrenoceptor
17) Confidence 0.13 Published 1996 Journal Pain Section Abstract Doc Link 8867263 Disease Relevance 0.27 Pain Relevance 0.27
These results indicate that a phentolamine dose of 1 mg/kg over 10 min more completely blocks alpha-adrenoceptor function than a dose of 0.5 mg/kg over 20 min.
Negative_regulation (blocks) of alpha-adrenoceptor
18) Confidence 0.13 Published 1996 Journal Pain Section Abstract Doc Link 8867263 Disease Relevance 0.06 Pain Relevance 0.15
The data suggest that phentolamine mesylate relaxes nonadrenergic noncholinergic neurons of the rabbit corpus cavernosum by activating NO synthase and is independent of alpha-adrenergic receptor blockade.
Negative_regulation (blockade) of alpha-adrenergic receptor in neurons
19) Confidence 0.08 Published 2001 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11468007 Disease Relevance 0 Pain Relevance 0.09
Especially, we aimed to clarify the interference of the alpha-adrenoceptor activity with NO mechanism in cutaneous microcirculation.
Negative_regulation (interference) of alpha-adrenoceptor
20) Confidence 0.05 Published 2009 Journal Microvasc. Res. Section Abstract Doc Link 19028506 Disease Relevance 0.43 Pain Relevance 0.30

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