INT47518

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Context Info
Confidence 0.42
First Reported 1980
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
nucleus 2
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 11 99.38 Very High Very High Very High
agonist 1 95.08 Very High Very High Very High
Locus ceruleus 3 80.88 Quite High
Dopamine 1 78.52 Quite High
medulla 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 83.56 Quite High
Hypertension 2 77.04 Quite High
Pressure Volume 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine and hydralazine significantly lowered phenylethanolamine N-methyltransferase (PNMT) activity elevated in the nucleus hypothalamicus posterior (NHP) of SHR to the level of KWR, and both drugs or alpha-methyldopa consistently increased PNMT in the nucleus paraventricularis (NPA).
Negative_regulation (lowered) of Positive_regulation (elevated) of PNMT in nucleus associated with clonidine
1) Confidence 0.42 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.32 Pain Relevance 0.65
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Negative_regulation (inhibitor) of Positive_regulation (peripheral) of PNMT
2) Confidence 0.41 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.08
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Negative_regulation (inhibitor) of Positive_regulation (peripheral) of PNMT
3) Confidence 0.41 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.07

General Comments

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