INT47528

Context Info Confidence 0.29 First Reported 1980 Last Reported 2008 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.47 Pain Relevance 0.58

cell proliferation (GFER) mitochondrion (GFER) oxidoreductase activity (GFER) extracellular region (GFER) cellular_component (GFER) cytoplasm (GFER)

Anatomy Link Frequency skin 1 ventral 1 GFER (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 4 99.08 Morphine 2 97.80 nociceptor 4 94.80 Mechanotransduction 1 57.60

Disease Link Frequency Relevance Heat Keloid Scars 13 100.00 Disease 5 99.28 Cicatrix 1 96.00 Stress 1 79.48 Adhesions 1 52.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, I hypothesize that FPDs of the skin, including keloids and HSs, are the result of an excessive responsiveness or functional failure of either dermal cell mechanoreceptors (mechanosensors) or mechanosensitive nociceptors of sensory fibers in the skin.

Regulation (result) of HSs in skin associated with nociceptor, keloid scars and disease

1) Confidence 0.29 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18614294 Disease Relevance 1.47 Pain Relevance 0.28

Rats trained on ventral tegmental intracranial self-stimulation (ICSS) were unaffected by acute injection of naloxone (2 mg/kg), while acute morphine (5 mg/kg) increased ICSS rate by 46%.

Neg (unaffected) Regulation (unaffected) of intracranial self-stimulation in ventral associated with narcan and morphine

2) Confidence 0.15 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7408948 Disease Relevance 0 Pain Relevance 0.30

General Comments

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