INT47543

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Context Info
Confidence 0.38
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.23
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Anatomy Link Frequency
ileum 1
nerve 1
bladder 1
autonomic nervous system 1
small intestine 1
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 5 99.76 Very High Very High Very High
antagonist 67 99.38 Very High Very High Very High
agonist 36 98.64 Very High Very High Very High
Dopamine 7 98.14 Very High Very High Very High
spastic colon 100 97.60 Very High Very High Very High
tetrodotoxin 6 97.58 Very High Very High Very High
cytokine 42 97.28 Very High Very High Very High
Inflammation 6 96.10 Very High Very High Very High
gABA 2 94.16 High High
Hippocampus 2 91.52 High High
Disease Link Frequency Relevance Heat
Hyperplasia 31 98.66 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

97 97.60 Very High Very High Very High
Overactive Bladder 71 97.20 Very High Very High Very High
INFLAMMATION 6 96.10 Very High Very High Very High
Targeted Disruption 207 95.76 Very High Very High Very High
Reprotox - General 2 2 95.20 Very High Very High Very High
Asthma 68 85.36 High High
Infection 69 84.24 Quite High
Muscular Spasm 2 80.48 Quite High
Depression 2 72.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional release studies performed in the presence of tetrodotoxin suggested that the dopamine release-stimulating M4 receptors are probably located on neuronal cell bodies, but that the release-facilitating M5 and the release-inhibiting M3 receptors are likely to be located on nerve terminals.
Positive_regulation (release-facilitating) of M3 in nerve associated with tetrodotoxin and dopamine
1) Confidence 0.38 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12151512 Disease Relevance 0.14 Pain Relevance 0.50
Circumstantial evidence suggests that the latter is involved in heterologous desensitization, which requires activation of both M2 and M3 receptors and is potently antagonized by M2 selective antagonists (Griffin et al. 2004).
Positive_regulation (activation) of M3 associated with antagonist
2) Confidence 0.32 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.45 Pain Relevance 0.05
These results suggest that atropine-sensitive phasic contraction is mainly mediated via the M3 receptor, and SP-mediated sustained contraction is negatively regulated by the M2 receptor at a presynaptic level.
Positive_regulation (mediated) of M3 receptor associated with substance p
3) Confidence 0.30 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17008557 Disease Relevance 0.47 Pain Relevance 0.41
The results are consistent with the postulate that 4-DAMP mustard treatment selectively inactivates M3 responses over M2, thereby converting the muscarinic behavior of the wild-type ileum into that of the M3 KO ileum.
Positive_regulation (inactivates) of M3 in ileum associated with targeted disruption
4) Confidence 0.28 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.63 Pain Relevance 0
This explains why there is little increase in conductance unless both the M2 and the Ca2+-mobilizing M3 receptor are activated simultaneously.
Positive_regulation (activated) of M3
5) Confidence 0.26 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0 Pain Relevance 0.08
The muscarinic antagonist, atropine (10(-10)-10(-6) M), enhanced 3H-ACh-release.
Positive_regulation (enhanced) of 3H-ACh-release associated with antagonist
6) Confidence 0.25 Published 1980 Journal Acta Physiol. Scand. Section Abstract Doc Link 7415847 Disease Relevance 0 Pain Relevance 0.24
being an important inducer of TH2 cytokine signaling from the lymph node and tissue and goblet cell hyperplasia and having a striking effect on the key smooth muscle contraction–inducing M3 muscarinic receptor (Figure 8).


Positive_regulation (inducing) of M3 in goblet cell associated with hyperplasia and cytokine
7) Confidence 0.23 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.45 Pain Relevance 0.09
M3 is the principal acetylcholine receptor in smooth muscle and drives 75% of the contractile response in the small intestine [16].
Positive_regulation (principal) of M3 in small intestine
8) Confidence 0.20 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.30 Pain Relevance 0.03
Stimulation of M2 and M3 receptors by acetylcholine causes bladder contractions that leads to urination (Chu 2006 and Erdem 2006).
Positive_regulation (Stimulation) of M3 in bladder associated with overactive bladder
9) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685261 Disease Relevance 1.42 Pain Relevance 0.07
The autonomic nervous system regulates the mucous secretion, tonicity of bronchial smooth muscles, blood flow, micro-vascular permeability, and functions of inflammatory cells.[22] Indirect support for the evidence of autonomic imbalance in IBS has been well established.[23] Acetylcholine secreted from the vagus lead to contraction of bronchial smooth muscle by stimulation of muscarinic receptors 3 (M3).
Positive_regulation (stimulation) of muscarinic receptors 3 in autonomic nervous system associated with inflammation and spastic colon
10) Confidence 0.01 Published 2010 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2841807 Disease Relevance 0.66 Pain Relevance 0.70
M3-receptor density was increased and abnormally distributed within the EEC.
Positive_regulation (increased) of M3-receptor
11) Confidence 0.00 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2777855 Disease Relevance 0.13 Pain Relevance 0

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