INT47546

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Context Info
Confidence 0.44
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.69
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
ACC 2
proximal 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 63 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
noradrenaline 16 100.00 Very High Very High Very High
opioid receptor 2 98.92 Very High Very High Very High
Anterior cingulate cortex 6 98.36 Very High Very High Very High
Opioid 6 97.06 Very High Very High Very High
headache 3 94.52 High High
Pain 5 89.48 High High
agonist 1 88.80 High High
Cannabinoid receptor 1 88.08 High High
Disease Link Frequency Relevance Heat
Migraine Disorders 26 100.00 Very High Very High Very High
Headache 33 99.44 Very High Very High Very High
Neurological Disease 5 97.20 Very High Very High Very High
Hypersensitivity 2 91.88 High High
Pain 5 89.48 High High
Migraine With Aura 11 81.64 Quite High
Dyssomnias 1 81.52 Quite High
Eating Disorder 1 80.92 Quite High
Appetite Loss 2 80.48 Quite High
Drug Dependence 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value =0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted.
DBH gene Binding (association) of associated with migraine
1) Confidence 0.44 Published 2000 Journal Neurogenetics Section Abstract Doc Link 11085595 Disease Relevance 0.74 Pain Relevance 1.02
Our laboratory has previously reported association of migraine with a promoter STR marker in the dopamine beta hydroxylase (DBH) gene.
DBH Binding (association) of associated with dopamine and migraine
2) Confidence 0.36 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19219470 Disease Relevance 0.87 Pain Relevance 0.83
After in vivo ligation for 24-48 h, large amounts of NA and dopamine-beta-hydroxylase (DBH) accumulated in the nerve segment immediately proximal to the ligature (P1).
DBH Binding (ligation) of in proximal associated with dopamine and noradrenaline
3) Confidence 0.36 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7418724 Disease Relevance 0 Pain Relevance 0.39
After in vivo ligation for 24-48 h, large amounts of NA and dopamine-beta-hydroxylase (DBH) accumulated in the nerve segment immediately proximal to the ligature (P1).
dopamine-beta-hydroxylase Binding (ligation) of in proximal associated with dopamine and noradrenaline
4) Confidence 0.36 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7418724 Disease Relevance 0 Pain Relevance 0.39
Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine.
dopamine beta-hydroxylase Binding (association) of associated with dopamine and migraine
5) Confidence 0.34 Published 2000 Journal Neurogenetics Section Title Doc Link 11085595 Disease Relevance 0.89 Pain Relevance 1.09
This rodent study defines opioid architecture in the perigenual and midcingulate divisions of ACC, relates mu-opioid receptor binding and G-protein activation, and localizes such binding to afferent axons with knife-cut lesions and specifically to noradrenergic terminals with immunotoxin lesions (anti-dopamine beta-hydroxylase-saporin; anti-DBH-saporin). [(3)H]Tyr-D-AlaGly-MePhe-Gly-ol (DAMGO) binding was highest in perigenual areas 32 and 24 with a peak in layer I.
anti-dopamine beta-hydroxylase-saporin Binding (binding) of in ACC associated with dopamine, opioid receptor, anterior cingulate cortex and opioid
6) Confidence 0.31 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714867 Disease Relevance 0.09 Pain Relevance 0.55
The results showed a significant association for allelic and genotypic frequency distribution between the DBH marker in the promoter and migraine in the first (P = 0.004 and P = 0.012, respectively) and the second (P = 0.013 and P = 0.031, respectively) tested cohorts.
DBH Binding (association) of associated with migraine
7) Confidence 0.30 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19219470 Disease Relevance 1.00 Pain Relevance 1.01
Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine.
DBH Binding (association) of associated with dopamine and migraine
8) Confidence 0.30 Published 2000 Journal Neurogenetics Section Title Doc Link 11085595 Disease Relevance 0.89 Pain Relevance 1.10
This rodent study defines opioid architecture in the perigenual and midcingulate divisions of ACC, relates mu-opioid receptor binding and G-protein activation, and localizes such binding to afferent axons with knife-cut lesions and specifically to noradrenergic terminals with immunotoxin lesions (anti-dopamine beta-hydroxylase-saporin; anti-DBH-saporin). [(3)H]Tyr-D-AlaGly-MePhe-Gly-ol (DAMGO) binding was highest in perigenual areas 32 and 24 with a peak in layer I.
anti-DBH-saporin Binding (binding) of in ACC associated with dopamine, opioid receptor, anterior cingulate cortex and opioid
9) Confidence 0.27 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714867 Disease Relevance 0.09 Pain Relevance 0.55
Further consideration of imputed genotype data from 2,937 British control individuals did not affirm the association with DRD2, but supported the associations with DBH and SLC6A3.
DBH Neg (not) Binding (associations) of
10) Confidence 0.14 Published 2009 Journal Hum. Genet. Section Abstract Doc Link 19152006 Disease Relevance 0.48 Pain Relevance 0.44
Therefore, we have developed a new drug, (R,Z)-18-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-18-oxooctadec-9-en-7-yl phenylacetate (PhAR-DBH-Me), that appears to bind and activate the CB1R.
PhAR-DBH-Me Binding (bind) of
11) Confidence 0.03 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20457524 Disease Relevance 0.64 Pain Relevance 0.47

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