INT4756

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Context Info
Confidence 0.33
First Reported 1985
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 37
Total Number 42
Disease Relevance 14.60
Pain Relevance 24.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
outflow 4
dorsal horn 4
brain 3
forebrain 2
hypothalamus 2
Nrtim1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 78 100.00 Very High Very High Very High
Enkephalin 31 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
Dynorphin 18 100.00 Very High Very High Very High
Neuropeptide 17 100.00 Very High Very High Very High
substance P 17 100.00 Very High Very High Very High
Calcitonin gene-related peptide 14 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
COX2 156 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 28 99.88 Very High Very High Very High
Nevus 30 99.76 Very High Very High Very High
Skin Cancer 118 99.12 Very High Very High Very High
Ganglion Cysts 3 99.08 Very High Very High Very High
Melanoma 24 98.96 Very High Very High Very High
Metastasis 46 98.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 98.48 Very High Very High Very High
Urological Neuroanatomy 16 98.32 Very High Very High Very High
Injury 7 98.06 Very High Very High Very High
Parkinson's Disease 8 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a model of mononeuropathic pain (chronic constriction injury of the sciatic nerve, CCI), we have demonstrated that light touch stimuli (stroking) to the paw induced Fos-like immunoreactivity (Fos-LI) in the superficial and deep dorsal horn of the rat spinal cord (Catheline et al., Pain 80 (1999a) 347).
Positive_regulation (induced) of immunoreactivity in sciatic nerve associated with pain, eae, injury, dorsal horn, sciatic nerve and spinal cord
1) Confidence 0.33 Published 2001 Journal Pain Section Abstract Doc Link 11376912 Disease Relevance 0.53 Pain Relevance 0.98
Increased striatal neuropeptide Y immunoreactivity and its modulation by deprenyl, clonidine and L-dopa in MPTP-treated mice.
Positive_regulation (Increased) of immunoreactivity associated with parkinson's disease, neuropeptide and clonidine
2) Confidence 0.13 Published 2003 Journal J Neural Transm Section Title Doc Link 14666410 Disease Relevance 0.56 Pain Relevance 0.45
Capsaicin induced a robust and dose-dependent c-fos-like immunoreactivity (c-fos LI) within Sp5C.
Spec (like) Positive_regulation (induced) of immunoreactivity associated with qutenza
3) Confidence 0.13 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12110114 Disease Relevance 0 Pain Relevance 0.47
5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
Positive_regulation (induced) of immunoreactivity in nucleus associated with qutenza
4) Confidence 0.13 Published 2002 Journal Cephalalgia Section Title Doc Link 12110114 Disease Relevance 0.05 Pain Relevance 0.99
Four days after either lesion placement or injection of 0.05-0.1 microgram kainic acid, immunoreactivity for all 3 peptides was altered throughout the intact mossy fiber system, bilaterally, but in distinctly different ways: enkephalin immunoreactivity (ENK-I) was dramatically elevated, dynorphin immunoreactivity was reduced, and CCK immunoreactivity (CCK-I) was either severely reduced or completely absent in the mossy fiber system.
Positive_regulation (elevated) of enkephalin immunoreactivity in mossy fiber associated with dynorphin, enkephalin and cholecystokinin
5) Confidence 0.07 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.23 Pain Relevance 0.71
We demonstrated that mice tolerant to morphine exhibited a significant increase in the level of protein kinase Cgamma-like immunoreactivity (PKCgamma-IR) in the dorsal horn of the spinal cord.
Positive_regulation (increase) of immunoreactivity in dorsal horn associated with dorsal horn, spinal cord and morphine
6) Confidence 0.04 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14725643 Disease Relevance 0.14 Pain Relevance 0.88
Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain.
Positive_regulation (increases) of immunoreactivity in forebrain associated with narcan
7) Confidence 0.04 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 10712293 Disease Relevance 0.07 Pain Relevance 0.84
Superfusion of slices of the rat urinary bladder with hypertonic NaCl produced a remarkable and concentration-dependent (150-280 mM) increase in the outflow of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI).
Positive_regulation (increase) of immunoreactivity in outflow associated with calcitonin gene-related peptide
8) Confidence 0.04 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1857548 Disease Relevance 0 Pain Relevance 0.46
Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain.
Positive_regulation (induced) of immunoreactivity in forebrain associated with narcan
9) Confidence 0.04 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 10712293 Disease Relevance 0.07 Pain Relevance 0.84
Furthermore, immunocytochemical studies revealed an increase of (Leu5)-enkephalin-like immunoreactivity in the perforant pathway and a decrease of DN-LI in the mossy fiber system of the hippocampus after 10 daily ECSs.
Spec (like) Positive_regulation (increase) of immunoreactivity in hippocampus associated with shock, hippocampus and enkephalin
10) Confidence 0.04 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860612 Disease Relevance 0.68 Pain Relevance 0.60
Ten daily ECSs also increased dynorphin A (1-8)-like immunoreactivity (DN-LI) in hypothalamus (45%) but not in frontal cortex.
Positive_regulation (increased) of immunoreactivity in frontal cortex associated with dynorphin, shock and urological neuroanatomy
11) Confidence 0.04 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860612 Disease Relevance 0.70 Pain Relevance 0.53
Ten daily electroconvulsive shocks (ECSs) caused a two-fold increase in (Met5)-enkephalin-like immunoreactivity (ME-LI) and an 80% increase in the level of mRNA coding for preproenkephalin A in the hypothalamus.
Positive_regulation (increase) of immunoreactivity in hypothalamus associated with shock and enkephalin
12) Confidence 0.04 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860612 Disease Relevance 0.59 Pain Relevance 0.34
Capsaicin (10 microM), KCl (80 mM) or superfusion with a low pH medium (pH 5 or 6) produced a significant increase of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) outflow from the superfused rat isolated soleus muscle.
Positive_regulation (increase) of immunoreactivity in muscle associated with qutenza and calcitonin gene-related peptide
13) Confidence 0.04 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1279475 Disease Relevance 0 Pain Relevance 0.56
COX2/PPARG immunoreactivity significantly increased from nevi to primary MM and metastases; COX2 positivity was associated with advanced Clark levels and shorter recurrence-free survival.
Positive_regulation (increased) of immunoreactivity associated with nevus, cox2, skin cancer, recurrence and metastasis
14) Confidence 0.01 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2712952 Disease Relevance 1.51 Pain Relevance 0.29
Likewise, PPARG immunoreactivity significantly increased from benign nevi (0%) to malignant melanomas (22%) and melanoma metastases (33%; P < .001; Figure 2(b)).
Positive_regulation (increased) of immunoreactivity associated with melanoma, nevus, skin cancer and metastasis
15) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 2.21 Pain Relevance 0.40
Superfusion of mucosa-free muscle slices of guinea-pig urinary bladder with 40 mM K+ produced a remarkable increase in calcitonin gene-related peptide-like immunoreactivity (CGRP-LI), that in this organ is entirely contained in capsaicin-sensitive nerves.
Positive_regulation (increase) of immunoreactivity in urinary bladder associated with qutenza and calcitonin gene-related peptide
16) Confidence 0.01 Published 1991 Journal Life Sci. Section Abstract Doc Link 1849214 Disease Relevance 0 Pain Relevance 0.25
The effect of neonatal capsaicin on the c-Fos-like immunoreactivity induced in subnucleus oralis neurons by noxious intraoral stimulation.
Positive_regulation (induced) of immunoreactivity in neurons associated with qutenza
17) Confidence 0.01 Published 2000 Journal Brain Res. Section Title Doc Link 10727645 Disease Relevance 0 Pain Relevance 0.94
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Positive_regulation (Induction) of immunoreactivity in brain associated with analgesic and opioid
18) Confidence 0.01 Published 1996 Journal Brain Res. Section Title Doc Link 8883853 Disease Relevance 0.07 Pain Relevance 1.13
The noxious stimulus-dependent induction of c-Fos-like immunoreactivity (Fos-LI) in neurons in the subnucleus oralis and the medullary dorsal horn (MDH) was significantly suppressed by the selective destruction of unmyelinated primary neurons.
Positive_regulation (induction) of immunoreactivity in dorsal horn associated with dorsal horn and unmyelinated
19) Confidence 0.01 Published 2000 Journal Brain Res. Section Abstract Doc Link 10727645 Disease Relevance 0 Pain Relevance 0.46
In the present study the effects of intracerebroventricular (i.c.v.) administration of 100 nmol of morphine, the selective mu-receptor agonist DAMGO, the delta-receptor agonist DPDPE and the kappa-receptor agonist U50,488H, on the induction of Fos-like immunoreactivity (Fos-LI) in the guinea-pig brain were investigated using immunohistochemical techniques.
Positive_regulation (induction) of immunoreactivity in brain associated with agonist, intracerebroventricular and morphine
20) Confidence 0.01 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883853 Disease Relevance 0.07 Pain Relevance 0.68

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