INT47563

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Context Info
Confidence 0.41
First Reported 1980
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 3 96.84 Very High Very High Very High
Catecholamine 1 89.72 High High
Somatostatin 12 88.48 High High
agonist 25 86.12 High High
Dopamine 16 85.76 High High
monoamine 3 75.00 Quite High
Neurotransmitter 9 71.04 Quite High
Serotonin 6 57.56 Quite High
noradrenaline 2 56.60 Quite High
antagonist 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 2 97.84 Very High Very High Very High
Starvation 10 97.26 Very High Very High Very High
Body Weight 3 25.00 Low Low
Obesity 4 19.44 Low Low
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.
Negative_regulation (suppressed) of Negative_regulation (episode) of GH associated with hypoglycemia
1) Confidence 0.41 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.19 Pain Relevance 0.53
In this as in in vitro studies, IGF-I mimicked the inhibitory feedback effect of GH on the CLON-induced GH surge, and IGF antisera blocked GH feedback.
Negative_regulation (blocked) of Negative_regulation (feedback) of GH
2) Confidence 0.22 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0 Pain Relevance 0.11
During starvation, the TSH response to TRH is diminished and, in most species, there is an increase in GH secretion with a decrease in IGF-1 levels and a rise in GH responsiveness to GHRH (448).
Negative_regulation (rise) of Negative_regulation (responsiveness) of GH associated with starvation
3) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.50 Pain Relevance 0

General Comments

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