INT4758

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 34
Speculated 34
Reported most in Abstract
Documents 557
Total Number 592
Disease Relevance 138.55
Pain Relevance 411.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 60
nerve 57
spinal cord 52
sensory nerves 48
sensory neurons 38
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3298 100.00 Very High Very High Very High
qutenza 2205 100.00 Very High Very High Very High
Glutamate 863 100.00 Very High Very High Very High
Pain 612 100.00 Very High Very High Very High
Neurotransmitter 532 100.00 Very High Very High Very High
Inflammation 515 100.00 Very High Very High Very High
substance P 446 100.00 Very High Very High Very High
Spinal cord 365 100.00 Very High Very High Very High
Neuropeptide 303 100.00 Very High Very High Very High
bradykinin 301 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 573 100.00 Very High Very High Very High
INFLAMMATION 557 100.00 Very High Very High Very High
Acidosis 429 100.00 Very High Very High Very High
Nociception 383 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 297 100.00 Very High Very High Very High
Neurogenic Inflammation 129 100.00 Very High Very High Very High
Injury 95 100.00 Very High Very High Very High
Cough 3 100.00 Very High Very High Very High
Ganglion Cysts 695 99.98 Very High Very High Very High
Pancreatitis 6 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the capsaicin-induced CGRP release was not blocked by tetrodotoxin treatment.
Positive_regulation (induced) of Localization (release) of CGRP associated with tetrodotoxin, qutenza and calcitonin gene-related peptide
1) Confidence 0.70 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.34
Capsaicin (1 x 10(-8)-1 x 10(-5) M) stimulated CGRP release in a concentration-dependent manner.
Positive_regulation (stimulated) of Localization (release) of CGRP associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.70 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.16
However, the capsaicin-induced CGRP release was not affected by pretreatment with 6-hydroxydopamine, a neurotoxin that causes a complete degeneration of adrenergic nerve terminals.
Positive_regulation (induced) of Localization (release) of CGRP in nerve associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.70 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.48
In the stomach from rats with defunctionalization of afferent neurons, the levels of the basal and capsaicin-induced CGRP release were below the limit of detection.
Positive_regulation (induced) of Localization (release) of CGRP in afferent neurons associated with qutenza and calcitonin gene-related peptide
4) Confidence 0.70 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.32
Increased in vivo release of calcitonin gene-related peptide-like material from the spinal cord in arthritic rats.
Positive_regulation (Increased) of Localization (release) of calcitonin gene-related peptide in spinal cord associated with analgesic, arthritis, spinal cord and calcitonin gene-related peptide
5) Confidence 0.70 Published 1993 Journal Pain Section Title Doc Link 8233535 Disease Relevance 0.19 Pain Relevance 0.82
CONCLUSION: Our results show that, in contrast to CGRP- or capsaicin-induced dural vasodilatation, 17beta-estradiol enhanced neurogenic vasodilatation, suggesting increased CGRP release from perivascular nerves.
Positive_regulation (increased) of Localization (release) of CGRP in nerves
6) Confidence 0.70 Published 2007 Journal Headache Section Body Doc Link 17300362 Disease Relevance 0 Pain Relevance 0
Veratridine stimulated secretion of CGRP immunoreactivity.
Positive_regulation (stimulated) of Localization (secretion) of CGRP associated with calcitonin gene-related peptide
7) Confidence 0.70 Published 1986 Journal Brain Res. Section Abstract Doc Link 3489500 Disease Relevance 0.17 Pain Relevance 0.67
Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells.
Positive_regulation (induced) of Localization (secretion) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion, calcitonin gene-related peptide and local anesthetic
8) Confidence 0.70 Published 1986 Journal Brain Res. Section Title Doc Link 3489500 Disease Relevance 0.19 Pain Relevance 0.75
We hypothesized that abdominal surgery-induced release of CGRP might inhibit postoperative colonic motility and food intake.
Positive_regulation (induced) of Localization (release) of CGRP associated with calcitonin gene-related peptide
9) Confidence 0.70 Published 1998 Journal Surgery Section Abstract Doc Link 9591004 Disease Relevance 0.27 Pain Relevance 0.22
The above results suggest that the observed release of CGRP in MAB was mediated by capsaicin-sensitive sensory nerve endings, as a result of Ca(2+)-induced Ca2+ release from the intracellular Ca2+ store which is sensitive to ruthenium red.
Positive_regulation (mediated) of Localization (release) of CGRP in sensory nerve associated with qutenza and calcitonin gene-related peptide
10) Confidence 0.70 Published 1995 Journal Sheng Li Xue Bao Section Abstract Doc Link 8762448 Disease Relevance 0.08 Pain Relevance 0.45
In the present study, it was observed that low pH, elevated levels of lactic acid, hypertonic NaCl and hypertonic sucrose caused CGRP release from isolated mesenteric arterial bed (MAB) of rat.
Positive_regulation (caused) of Localization (release) of CGRP associated with calcitonin gene-related peptide
11) Confidence 0.70 Published 1995 Journal Sheng Li Xue Bao Section Abstract Doc Link 8762448 Disease Relevance 0.10 Pain Relevance 0.40
Daily oral treatment with topiramate for 4 and 8 weeks led to a dose- and time-dependent reduction of IS-induced CGRP release.
Positive_regulation (induced) of Localization (release) of CGRP associated with calcitonin gene-related peptide
12) Confidence 0.70 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19558535 Disease Relevance 0.24 Pain Relevance 0.72
In the diabetic rat ileum, however, there was no increase in the release of vasoactive intestinal polypeptide and calcitonin gene-related peptide during electrical stimulation, whereas endogenous release of acetylcholine, serotonin, and substance P was unaffected by the diabetic state.
Neg (no) Positive_regulation (increase) of Localization (release) of calcitonin in ileum associated with diabetes mellitus, serotonin, substance p and calcitonin gene-related peptide
13) Confidence 0.70 Published 1987 Journal Gastroenterology Section Abstract Doc Link 2443415 Disease Relevance 0.42 Pain Relevance 0.43
In the present study, Nitroglycerin caused a concentration-dependent relaxation concomitantly with a significant increase in the release of CGRP in the isolated rat thoracic aorta, an effect that was reduced by preincubation with capsaicin.
Positive_regulation (increase) of Localization (release) of CGRP in thoracic aorta associated with qutenza and calcitonin gene-related peptide
14) Confidence 0.70 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17804099 Disease Relevance 0.09 Pain Relevance 0.47
Previous investigations have suggested that vasodilator responses to nitroglycerin involve in stimulation of calcitonin gene-related peptide (CGRP) release.
Positive_regulation (stimulation) of Localization (release) of CGRP associated with calcitonin gene-related peptide
15) Confidence 0.70 Published 2001 Journal Life Sci. Section Abstract Doc Link 11521755 Disease Relevance 0 Pain Relevance 0.27
The present study suggests that the depressor effect of nitroglycerin is related to stimulation of CGRP release in the rat.
Positive_regulation (stimulation) of Localization (release) of CGRP associated with calcitonin gene-related peptide
16) Confidence 0.70 Published 2001 Journal Life Sci. Section Abstract Doc Link 11521755 Disease Relevance 0 Pain Relevance 0.38
Neither nifedipine (1 x 10(-6) M), the L-type Ca(2+)-channel antagonist, nor indomethacin (1 x 10(-5) M), inhibitor of prostaglandin synthesis, altered acid-induced CGRP release.
Neg (Neither) Positive_regulation (induced) of Localization (release) of CGRP associated with antagonist
17) Confidence 0.70 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506420 Disease Relevance 0 Pain Relevance 0.52
Conotoxin (1 x 10(-7) M), the selective blocker of N-type calcium channels, also significantly inhibited proton (pH 4.0)-induced CGRP release to values that were 74% below net stimulated levels.
Positive_regulation (induced) of Localization (release) of CGRP associated with calcium channel and conotoxin
18) Confidence 0.70 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506420 Disease Relevance 0 Pain Relevance 0.36
Capsazepine (1 x 10(-4) M), a specific capsaicin receptor antagonist, also completely abolished acid-induced CGRP release.
Positive_regulation (induced) of Localization (release) of CGRP associated with qutenza and antagonist
19) Confidence 0.70 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506420 Disease Relevance 0 Pain Relevance 0.58
Because activation of the cAMP transduction cascade produces acute sensitization in rat sensory neurons, we examined whether continuous activation of the cAMP pathway augments bradykinin-stimulated release of immunoreactive substance P and immunoreactive calcitonin gene-related peptide from embryonic rat sensory neurons grown in culture.
Spec (whether) Positive_regulation (augments) of Localization (release) of calcitonin in sensory neurons associated with bradykinin, calcitonin gene-related peptide and substance p
20) Confidence 0.70 Published 2000 Journal Pain Section Abstract Doc Link 11068115 Disease Relevance 0.31 Pain Relevance 0.39

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