INT4759

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 294
Total Number 297
Disease Relevance 82.62
Pain Relevance 226.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 38
nerve 27
sensory nerves 24
spinal cord 20
trigeminal ganglia 14
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1482 100.00 Very High Very High Very High
qutenza 1086 100.00 Very High Very High Very High
Glutamate 427 100.00 Very High Very High Very High
Pain 296 100.00 Very High Very High Very High
Inflammation 287 100.00 Very High Very High Very High
Neurotransmitter 267 100.00 Very High Very High Very High
Spinal cord 217 100.00 Very High Very High Very High
Morphine 137 100.00 Very High Very High Very High
Neuropeptide 136 100.00 Very High Very High Very High
substance P 129 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 298 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 187 100.00 Very High Very High Very High
Neurogenic Inflammation 84 100.00 Very High Very High Very High
Hypoxia 42 100.00 Very High Very High Very High
Cancer 15 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 14 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Acidosis 1 100.00 Very High Very High Very High
Nociception 219 99.74 Very High Very High Very High
Diabetes Mellitus 71 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Age-related decrease of neurogenic release of calcitonin gene-related peptide from perivascular nerves in spontaneously hypertensive rats.
Negative_regulation (decrease) of Localization (release) of calcitonin gene-related peptide in nerves associated with hypertension and calcitonin gene-related peptide
1) Confidence 0.59 Published 1992 Journal Clin Exp Hypertens A Section Title Doc Link 1424225 Disease Relevance 0.19 Pain Relevance 0.45
Release of CGRP evoked by capsaicin concentrations in the range of 0.1-0.3 microM in either dosage protocol was reduced in the presence of Ruthenium Red (RR, 2.5 microM).
Negative_regulation (reduced) of Localization (Release) of CGRP associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.59 Published 1992 Journal Regul. Pept. Section Abstract Doc Link 1374925 Disease Relevance 0 Pain Relevance 1.46
On the other hand, the capsaicin-induced CGRP release was not blocked by tetrodotoxin treatment.
Negative_regulation (blocked) of Localization (release) of CGRP associated with tetrodotoxin, qutenza and calcitonin gene-related peptide
3) Confidence 0.59 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.34
CONCLUSIONS: Intravesical BTX administration blocked acetic acid induced bladder pain responses and inhibited CGRP release from afferent nerve terminals.
Negative_regulation (inhibited) of Localization (release) of CGRP in bladder
4) Confidence 0.59 Published 2004 Journal J. Urol. Section Body Doc Link 15371885 Disease Relevance 0.11 Pain Relevance 0
Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells.
Negative_regulation (inhibit) of Localization (secretion) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion, calcitonin gene-related peptide and local anesthetic
5) Confidence 0.59 Published 1986 Journal Brain Res. Section Title Doc Link 3489500 Disease Relevance 0.19 Pain Relevance 0.75
In young SHRs, clenbuterol seems to inhibit CGRP release, while in old SHRs, it increases the release of and response to noradrenaline and decreases neuronal nitric oxide (NO) release.
Negative_regulation (inhibit) of Localization (release) of CGRP in neuronal associated with noradrenaline and calcitonin gene-related peptide
6) Confidence 0.59 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12694812 Disease Relevance 0.07 Pain Relevance 0.36
The inhibition of CGRP release by topiramate offers a possible mechanism that may in part account for the preventative antimigraine activity of this drug.
Negative_regulation (inhibition) of Localization (release) of CGRP associated with cluster headache and calcitonin gene-related peptide
7) Confidence 0.59 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19558535 Disease Relevance 0.32 Pain Relevance 0.68
The calcitonin gene-related peptide release in response to capsaicin was significantly reduced after 4 weeks treatment with TC.
Negative_regulation (reduced) of Localization (release) of calcitonin associated with qutenza and calcitonin gene-related peptide
8) Confidence 0.59 Published 1995 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7544420 Disease Relevance 0.08 Pain Relevance 0.68
Pretreatment with nitroglycerin significantly decreased its vasodilation and depressor effect and the release of CGRP, which was restored in the presence of vinpocetine, an inhibitor of phosphodiesterase.
Negative_regulation (decreased) of Localization (release) of CGRP associated with increased venous pressure under development and calcitonin gene-related peptide
9) Confidence 0.59 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17804099 Disease Relevance 0.10 Pain Relevance 0.49
Previous studies have shown that the development of tolerance to nitroglycerin is related to reduction of endogenous calcitonin gene-related peptide (CGRP) release.
Negative_regulation (reduction) of Localization (release) of CGRP associated with tolerance and calcitonin gene-related peptide
10) Confidence 0.59 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17804099 Disease Relevance 0.08 Pain Relevance 0.44
In the present study, Nitroglycerin caused a concentration-dependent relaxation concomitantly with a significant increase in the release of CGRP in the isolated rat thoracic aorta, an effect that was reduced by preincubation with capsaicin.
Negative_regulation (reduced) of Localization (release) of CGRP in thoracic aorta associated with qutenza and calcitonin gene-related peptide
11) Confidence 0.59 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17804099 Disease Relevance 0.09 Pain Relevance 0.48
In contrast, ruthenium red (1 x 10(-5) M), capsaicin antagonist, almost completely prevented acid (pH 4.0)-stimulated CGRP release.
Negative_regulation (prevented) of Localization (release) of CGRP associated with qutenza and antagonist
12) Confidence 0.59 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506420 Disease Relevance 0 Pain Relevance 0.55
Capsazepine (1 x 10(-4) M), a specific capsaicin receptor antagonist, also completely abolished acid-induced CGRP release.
Negative_regulation (abolished) of Localization (release) of CGRP associated with qutenza and antagonist
13) Confidence 0.59 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506420 Disease Relevance 0 Pain Relevance 0.59
Conotoxin (1 x 10(-7) M), the selective blocker of N-type calcium channels, also significantly inhibited proton (pH 4.0)-induced CGRP release to values that were 74% below net stimulated levels.
Negative_regulation (inhibited) of Localization (release) of CGRP associated with calcium channel and conotoxin
14) Confidence 0.59 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506420 Disease Relevance 0 Pain Relevance 0.36
Additionally, anandamide inhibited K+- as well as capsaicin-evoked immunoreactive calcitonin gene-related peptide release.
Negative_regulation (inhibited) of Localization (release) of calcitonin associated with qutenza and calcitonin gene-related peptide
15) Confidence 0.59 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9600630 Disease Relevance 0.51 Pain Relevance 1.38
The capsaicin (3 microM)-evoked release of the immunoreactive calcitonin gene-related peptide (iCGRP) from dorsal-half slices of the rat lumbar spinal cord was substantially reduced in slices from rats which had undergone dorsal rhizotomy.
Negative_regulation (reduced) of Localization (release) of iCGRP in dorsal associated with dorsal rhizotomy, qutenza, spinal cord and calcitonin gene-related peptide
16) Confidence 0.59 Published 1989 Journal Neurosci. Res. Section Abstract Doc Link 2797508 Disease Relevance 0.29 Pain Relevance 0.54
Pretreatment with capsaicin (50 mg/kg, s.c.), which specifically depletes the transmitter content of sensory nerves, also abolished the protective effects of nitroglycerin and markedly reduced the release of CGRP from the heart during nitroglycerin perfusion.
Negative_regulation (reduced) of Localization (release) of CGRP in heart associated with qutenza and calcitonin gene-related peptide
17) Confidence 0.59 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10206178 Disease Relevance 0.07 Pain Relevance 0.56
Nitroglycerin (10(-4) M) caused a greater than twofold increase over basal levels in calcitonin gene-related peptide release in nontolerant rings, which was abolished in rings treated with capsaicin and in nitrate tolerant rings.
Negative_regulation (abolished) of Localization (release) of calcitonin gene-related peptide associated with qutenza and calcitonin gene-related peptide
18) Confidence 0.59 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16495753 Disease Relevance 0 Pain Relevance 0.81
We conclude that NE affected stimulated PGE2 release via alpha2-adrenoceptors on cells other than cutaneous afferents while kappa-opioid receptors are expressed in peripheral terminals of cutaneous afferents and their activation reduced CGRP release and secondary PGE2 formation.
Negative_regulation (reduced) of Localization (release) of CGRP in PGE2 associated with kappa opioid receptor and calcitonin gene-related peptide
19) Confidence 0.59 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.53
Treatment of the rats with flurbiprofen (25 mg/kg i.p.) one hour before dissection reduced PGE(2) to detection level and inhibited the CGRP secretion evoked by the combination of bradykinin, serotonin and histamine (all 10(-6) M).
Negative_regulation (inhibited) of Localization (secretion) of CGRP associated with serotonin, bradykinin and calcitonin gene-related peptide
20) Confidence 0.59 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11166334 Disease Relevance 0.18 Pain Relevance 0.92

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox