INT4760

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 93
Total Number 95
Disease Relevance 34.19
Pain Relevance 60.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
DRG 25
plasma 16
neurons 9
nerve 9
neuronal 6
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 774 100.00 Very High Very High Very High
qutenza 394 100.00 Very High Very High Very High
substance P 312 100.00 Very High Very High Very High
Pain 199 100.00 Very High Very High Very High
Somatostatin 154 100.00 Very High Very High Very High
Neuropeptide 153 100.00 Very High Very High Very High
Spinal cord 132 100.00 Very High Very High Very High
dorsal root ganglion 65 100.00 Very High Very High Very High
Dorsal horn 41 100.00 Very High Very High Very High
medulla 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 207 100.00 Very High Very High Very High
Ganglion Cysts 98 100.00 Very High Very High Very High
Hypertension 62 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 56 100.00 Very High Very High Very High
Hypoxia 26 100.00 Very High Very High Very High
Burning Mouth Syndrome 9 99.84 Very High Very High Very High
Urological Neuroanatomy 21 99.68 Very High Very High Very High
Fever 4 99.50 Very High Very High Very High
Injury 25 99.40 Very High Very High Very High
Diabetes Mellitus 20 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that relief of clinical pain after shock wave application may result from reduced CGRP expression in DRG neurons.
Negative_regulation (reduced) of Gene_expression (expression) of CGRP in neurons associated with dorsal root ganglion, pain, shock and calcitonin gene-related peptide
1) Confidence 0.59 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12963418 Disease Relevance 1.41 Pain Relevance 0.77
CGRP accumulation was also observed in sural nerve proximal stump tips, indicating its presence in sensory axons despite the known declines in the sensory neuronal synthesis of CGRP that occur following axotomy.
Negative_regulation (declines) of Gene_expression (synthesis) of CGRP in nerve associated with calcitonin gene-related peptide
2) Confidence 0.59 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376593 Disease Relevance 0.17 Pain Relevance 0.54
Decreased synthesis and release of CGRP is related to a reduction in NO levels, and corresponds to the increased concentrations of ADMA in spontaneously hypertensive rats.
Negative_regulation (Decreased) of Gene_expression (synthesis) of CGRP associated with hypertension and calcitonin gene-related peptide
3) Confidence 0.59 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18782573 Disease Relevance 0.31 Pain Relevance 0.36
Decrease in the synthesis and release of calcitonin gene-related peptide in dorsal root ganglia of spontaneously hypertensive rat: role of nitric oxide synthase inhibitors.
Negative_regulation (Decrease) of Gene_expression (synthesis) of calcitonin gene-related peptide in dorsal root ganglia associated with hypertension and calcitonin gene-related peptide
4) Confidence 0.59 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18782573 Disease Relevance 0.24 Pain Relevance 0.44
The decrease in CGRP synthesis and release contributes to the elevated blood pressure, as shown in the spontaneously hypertensive rats, alpha-CGRP knockout mice, Dahl-salt or phenol-induced hypertensive rats.
Negative_regulation (decrease) of Gene_expression (synthesis) of CGRP in blood associated with targeted disruption, pressure and volume under development, hypertension and calcitonin gene-related peptide
5) Confidence 0.58 Published 2005 Journal Peptides Section Abstract Doc Link 16112410 Disease Relevance 0.94 Pain Relevance 0.59
This enhancement of acute and then chronic gastric lesions was accompanied by a significant fall in GBF, an elevation of plasma gastrin and a decrease in mucosal expression of CGRP.
Negative_regulation (decrease) of Gene_expression (expression) of CGRP in plasma associated with calcitonin gene related peptide
6) Confidence 0.58 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787759 Disease Relevance 0.51 Pain Relevance 0.54
Pretreatment with capsaicin (50 mg/kg, s.c.), which depletes transmitters in capsaicin-sensitive sensory nerves, also blocked the cardioprotection of preconditioning and reduced the synthesis and release of CGRP, but did not affect the concentration of NO.
Negative_regulation (reduced) of Gene_expression (synthesis) of CGRP in sensory nerves associated with qutenza and calcitonin gene-related peptide
7) Confidence 0.58 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464099 Disease Relevance 0.35 Pain Relevance 0.71
However, a direct single application of p38 inhibitor did not suppress CGRP expression in innervating DRG neurons.
Neg (not) Negative_regulation (suppress) of Gene_expression (expression) of CGRP in DRG associated with dorsal root ganglion and calcitonin gene-related peptide
8) Confidence 0.57 Published 2009 Journal Spine Section Abstract Doc Link 20010392 Disease Relevance 0.40 Pain Relevance 0.53
These data suggest that CGRP and SOM synthesis in primary sensory neurons is reduced in STZ-induced diabetic rats.
Negative_regulation (reduced) of Gene_expression (synthesis) of CGRP in primary sensory neurons associated with diabetes mellitus and somatostatin
9) Confidence 0.56 Published 1996 Journal Peptides Section Abstract Doc Link 8899822 Disease Relevance 0.93 Pain Relevance 0.40
CGRP expression was diminished in the second week than the first week, and that was especially obvious in the posterior root and ganglion cell.
Negative_regulation (diminished) of Gene_expression (expression) of CGRP in ganglion cell
10) Confidence 0.53 Published 2004 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 15598371 Disease Relevance 0 Pain Relevance 0
In vehicle-treated rats there is a decrease in IB4 binding and CGRP expression in injured neurones, while in BRX-220-treated rats these markers were better preserved.
Negative_regulation (decrease) of Gene_expression (expression) of CGRP in IB4 associated with calcitonin gene-related peptide
11) Confidence 0.53 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.56 Pain Relevance 0.54
CONCLUSION: These results indicate that the decreased production and release of CGRP and reduced vascular NGF content are attributed to the activation of alpha2-adrenoreceptors in phenol-induced hypertensive rats.


Negative_regulation (decreased) of Gene_expression (production) of CGRP
12) Confidence 0.51 Published 2005 Journal J. Hypertens. Section Body Doc Link 15716703 Disease Relevance 0 Pain Relevance 0
In the posterior horn of all three injured groups, the expression of CGRP decreased gradually from day 1 to day 14 after the operation and was significantly lower on day 14 compared to day 1.
Negative_regulation (decreased) of Gene_expression (expression) of CGRP in posterior associated with calcitonin gene-related peptide
13) Confidence 0.51 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 19969463 Disease Relevance 0.38 Pain Relevance 0.48
In the anterior horn of all three injured groups, the expression of CGRP increased progressively from day 1 to day 7 (p<0.05), peaked on day 7, and then began to decrease slowly.
Negative_regulation (decrease) of Gene_expression (expression) of CGRP in anterior associated with calcitonin gene-related peptide
14) Confidence 0.51 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 19969463 Disease Relevance 0.40 Pain Relevance 0.48
More importantly, the kappa-opioid asimadoline reduced the expression of both SP and calcitonin gene-related peptide-alpha (alpha-CGRP) in DRG cells but had no effect on the very low expression of neuropeptides in non-neuronal tissue.
Negative_regulation (reduced) of Gene_expression (expression) of alpha-CGRP in neuronal associated with neuropeptide, opioid, calcitonin gene-related peptide and substance p
15) Confidence 0.51 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021980 Disease Relevance 0.25 Pain Relevance 0.99
The cardioprotection as well as the synthesis and release of CGRP induced by MLA were completely abolished by pretreatment with zinc protoporphrin IX (ZnPP-9), an inhibitor of HO-1, or by capsaicin (50 mg/kg, s.c.), which selectively depletes transmitters in capsaicin-sensitive sensory nerves.
Negative_regulation (abolished) of Gene_expression (synthesis) of CGRP in sensory nerves associated with qutenza and calcitonin gene-related peptide
16) Confidence 0.51 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 11738242 Disease Relevance 0 Pain Relevance 0.69
Calcitonin gene-related peptide (CGRP) expression in motoneurons was markedly reduced from the second week after avulsion.
Negative_regulation (reduced) of Gene_expression (expression) of CGRP in motoneurons associated with calcitonin gene-related peptide
17) Confidence 0.49 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.05
This hypothesis is further supported by the fact that it was recently shown that stressors decrease CGRP expression in the frontal cortex, hippocampus, occipital cortex and hypothalamus [42].
Negative_regulation (decrease) of Gene_expression (expression) of CGRP in hypothalamus associated with urological neuroanatomy, hippocampus and calcitonin gene-related peptide
18) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.32 Pain Relevance 1.10
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Negative_regulation (regulated) of Gene_expression (expression) of CGRP associated with substance p and calcitonin gene-related peptide
19) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.95 Pain Relevance 1.11
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Negative_regulation (down) of Gene_expression (expression) of CGRP associated with substance p and calcitonin gene-related peptide
20) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.95 Pain Relevance 1.11

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