INT47615

Context Info Confidence 0.58 First Reported 1980 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 3.62 Pain Relevance 1.74

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)

Anatomy Link Frequency hepatocytes 1 saliva 1 neutrophil 1 DNASE1 (Homo sapiens)

Pain Link Frequency Relevance Heat halothane 1 99.90 anesthesia 6 98.08 Bile 4 97.92 Inflammatory response 4 97.68 fibrosis 11 94.64 Inflammatory mediators 2 93.84 Inflammation 16 92.16 Chronic pancreatitis 4 87.92 cytokine 1 80.64 Buprenorphine 2 79.92

Disease Link Frequency Relevance Heat Apoptosis 59 99.04 Disease 12 98.10 INFLAMMATION 21 97.68 Pancreatitis 8 95.88 Cystic Fibrosis 11 94.64 Benign Prostatic Hypertrophy 2 90.68 Necrosis 1 87.64 Cancer 29 87.28 Death 12 85.92 Breast Cancer 2 83.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The final preparation inhibited DNase I only, and had no inhibitory activity on pancreatic RNase, and trypsin.

Negative_regulation (inhibited) of DNase I

1) Confidence 0.58 Published 1980 Journal Gastroenterol. Jpn. Section Abstract Doc Link 7450390 Disease Relevance 0.13 Pain Relevance 0.15

Zn(2+) as high as 2 mM did not inhibit the DNase that took part in this apoptosis.

Negative_regulation (inhibit) of DNase associated with apoptosis

2) Confidence 0.48 Published 2004 Journal Life Sci. Section Abstract Doc Link 15135650 Disease Relevance 1.00 Pain Relevance 0.23

The expression of inhibitor of caspase activated DNase (ICAD) was reduced with the lapse of time.

Negative_regulation (inhibitor) of DNase

3) Confidence 0.45 Published 2005 Journal Zhonghua Zhong Liu Za Zhi Section Body Doc Link 16188123 Disease Relevance 0.16 Pain Relevance 0

Then clinical studies were made on the DNase I inhibitor in duodenal juice obtained after administration of Pancreozymin and Secretin to patients with various pancreatic diseases.

Negative_regulation (inhibitor) of DNase I associated with bile and pancreatitis

4) Confidence 0.43 Published 1980 Journal Gastroenterol. Jpn. Section Abstract Doc Link 7450390 Disease Relevance 0.25 Pain Relevance 0.26

The anesthetic halothane can inhibit the released neutral and acid DNase activities.

Negative_regulation (inhibit) of DNase associated with halothane

5) Confidence 0.38 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.22

However before adding such buffers saliva should be stored on ice (+4°C) to prevent bacterial (or other microbial growth) and to decrease salivary DNase activity.

Negative_regulation (decrease) of DNase in saliva

6) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0 Pain Relevance 0

Since our experimental data indicated a decrease in acid DNase activity 24 h after exposure to SNP or peroxynitrite (Table 2), the inhibition of DNase II may be explained by the nitrosylation of its susceptible sites.

Negative_regulation (decrease) of DNase

7) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.27 Pain Relevance 0

After in vitro exposure of isolated hepatocytes to SNP or peroxynitrite, the activity of both alkaline and acid DNase decreased in a dose-dependent fashion (Figure 2).

Negative_regulation (decreased) of DNase in hepatocytes

8) Confidence 0.03 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0 Pain Relevance 0

For patients with established disease, recent and projected advances in therapies that are directed at neutrophil products, such as DNase, antioxidants, and protease inhibitors, hold great promise for limiting the consequences of the inflammatory response.

Negative_regulation (inhibitors) of DNase in neutrophil associated with inflammatory response and disease

9) Confidence 0.01 Published 2005 Journal Treat Respir Med Section Abstract Doc Link 16086599 Disease Relevance 1.81 Pain Relevance 0.88

General Comments

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