INT4762

Context Info Confidence 0.45 First Reported 1992 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.68 Pain Relevance 0.80

cytosol (DHCR24) small molecule metabolic process (DHCR24) Golgi apparatus (DHCR24) endoplasmic reticulum (DHCR24) cytoskeleton (DHCR24) nucleus (DHCR24)

Anatomy Link Frequency nucleus 1 DHCR24 (Homo sapiens)

Pain Link Frequency Relevance Heat amygdala 4 99.04 Arthritis 3 94.64 Enkephalin 1 92.72 substance P 1 84.76 Dynorphin 1 83.16 antagonist 2 75.16 Neuropeptide 1 75.00 Pain 3 65.56 Inflammation 1 55.64 Analgesic 1 54.76

Disease Link Frequency Relevance Heat Arthritis 3 94.64 Acute Renal Failure 1 77.52 Anxiety Disorder 4 67.72 Pain 2 65.56 INFLAMMATION 2 55.64 Hemolysis 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When atropine-induced suppression of the DCE, Fos pattern was modified in the mPFC with a change in Fos immunoreactivity, but no longer associated with the DCE.

Negative_regulation (suppression) of DCE

1) Confidence 0.45 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16678862 Disease Relevance 0.18 Pain Relevance 0.19

Compared to the normal DCE, atropine-induced disruption of the DCE was associated with an increase of the amount of Fos immunoreactive neurons within the central nucleus of the amygdala.

Negative_regulation (disruption) of DCE in nucleus associated with amygdala

2) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16678862 Disease Relevance 0.20 Pain Relevance 0.20

Both SPE and DCE were significantly decreased 15 days after the intraarticular injection.

Negative_regulation (decreased) of DCE

3) Confidence 0.14 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1279476 Disease Relevance 0.18 Pain Relevance 0.34

Experiments with P450-selective chemical inhibitors and monoclonal anti-P450 antibodies showed that furafylline, a mechanism-based inhibitor CYP1A2, and anti-CYP1A2 antibody markedly inhibited 6-MNA formation, whereas inhibitors for other P450s did not show significant inhibitory effects.

Negative_regulation (inhibitors) of P450-selective

4) Confidence 0.02 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 19204080 Disease Relevance 0.06 Pain Relevance 0.08

Patients were divided in 2 groups according to the GFR percent change in comparison to the baseline value found 24 hours after CS (deltaGFR24): Group 1, deltaGFR24 decrease higher than 20% (n = 11) and Group 2, deltaGFR24 decrease < or = 20% or deltaGFR24 increase (n = 10).

Negative_regulation (decrease) of deltaGFR24

5) Confidence 0.01 Published 2000 Journal Ren Fail Section Abstract Doc Link 10901186 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.