INT47628

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Context Info
Confidence 0.60
First Reported 1980
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 4.50
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
blood 1
hematopoietic stem cell 1
stromal cell 1
red blood cell 1
chief cells 1
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 12 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
noradrenaline 1 100.00 Very High Very High Very High
Angina 1 95.28 Very High Very High Very High
Arthritis 28 95.20 Very High Very High Very High
tolerance 1 91.36 High High
Endogenous opioid 3 91.04 High High
Disease Link Frequency Relevance Heat
Cancer 156 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1 100.00 Very High Very High Very High
Hyperlipidemia 1 99.42 Very High Very High Very High
Death 10 97.36 Very High Very High Very High
Apoptosis 53 96.92 Very High Very High Very High
Infection 12 95.72 Very High Very High Very High
Cv General 3 Under Development 1 95.28 Very High Very High Very High
Arthritis 29 95.20 Very High Very High Very High
Targeted Disruption 18 94.52 High High
Necrosis 10 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes precede an alteration in somatostatin cell number and mRNA and, coupled with reductions in parietal and chief cells, may contribute both to severe impairment of gastric acid output and the potential for carcinogenic processes.
Regulation (alteration) of cell in chief cells associated with somatostatin
1) Confidence 0.60 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10961708 Disease Relevance 0.64 Pain Relevance 0.19
Effects of enhanced counterpulsation on vascular cell release of coagulation factors.
Regulation (Effects) of cell
2) Confidence 0.44 Published 2005 Journal Heart Lung Section Title Doc Link 16027645 Disease Relevance 0.18 Pain Relevance 0.14
We studied the in vitro effects of noradrenaline, prostaglandin F2 alpha, thromboxane A2, leukotriene B4, angiotensin II, vasopressin, indomethacin, prazosin, hydralazine, clonidine, reserpine, prostaglandin I2, indapamide, furosemide, amlodipine, verapamil and irbesartan on purified human red blood cell CA I and vascular smooth muscle CA I isolated from rabbits.
Regulation (effects) of cell in red blood cell associated with noradrenaline and clonidine
3) Confidence 0.44 Published 2001 Journal Drugs Exp Clin Res Section Abstract Doc Link 11392054 Disease Relevance 0 Pain Relevance 0.15
Cell 1, 933-938), the role of insulin in the control of other beta-cell genes is unexplored.
Regulation (control) of cell
4) Confidence 0.26 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10967119 Disease Relevance 0 Pain Relevance 0.04
The present study was performed to determine the effects of the opioid antagonist, naloxone, on human NK activity in vitro.
Spec (determine) Regulation (effects) of NK associated with antagonist, narcan and opioid
5) Confidence 0.26 Published 1994 Journal Isr. J. Med. Sci. Section Abstract Doc Link 8088979 Disease Relevance 0 Pain Relevance 0.72
Similar drug treatment failed, however, to produce significant changes in the cytotoxicity of HPNKC preparations, suggesting that modulation of the PBMC's NKC activity and that of HPNKC samples require different kinds of cell's derived signal.
Regulation (modulation) of NKC in PBMC
6) Confidence 0.26 Published 2008 Journal Headache Section Body Doc Link 18479418 Disease Relevance 0 Pain Relevance 0
These changes precede an alteration in somatostatin cell number and mRNA and, coupled with reductions in parietal and chief cells, may contribute both to severe impairment of gastric acid output and the potential for carcinogenic processes.
Regulation (alteration) of cell in parietal associated with somatostatin
7) Confidence 0.20 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10961708 Disease Relevance 0.64 Pain Relevance 0.19
All blood and BAL samples were collected and handled by the same investigator.
Spec (investigator) Regulation (handled) of BAL in blood
8) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0.54 Pain Relevance 0.07
After logarithmic transformation, BAL-urea IL-8 values were stable in the low VT group (P = 0.20) but increased in the high VT group (P = 0.03) with significant differences after 12 hours (P = 0.03).
Regulation (values) of BAL
9) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0 Pain Relevance 0.03
However, stromal cell markers seem not affected and quantification is possible, supporting flow cytometry tissue analysis as a tool to study these cell populations in arthritis.



Neg (not) Spec (seem) Regulation (affected) of cell in stromal cell associated with arthritis
10) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875643 Disease Relevance 0.31 Pain Relevance 0.19
In types IIa, IIb and IV hyperlipoproteinaemia cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol were affected markedly stronger by procetofene and bezafibrate than by etofibrate retard.
Regulation (affected) of LDL-cholesterol associated with hyperlipidemia and disorder of lipid metabolism
11) Confidence 0.01 Published 1980 Journal Artery Section Abstract Doc Link 7458677 Disease Relevance 0.44 Pain Relevance 0.08
For example, p53 has a critical role in regulating hematopoietic stem cell quiescence [75, 76].
Regulation (regulating) of cell in hematopoietic stem cell
12) Confidence 0.00 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.55 Pain Relevance 0
Screenings to find novel small molecules that specifically target cancer stem cell populations have been carried out.
Regulation (target) of cell in stem cell associated with cancer
13) Confidence 0.00 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.18 Pain Relevance 0.05

General Comments

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