INT47645

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Context Info
Confidence 0.11
First Reported 1980
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
vascular endothelium 2
kidney 2
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 14 98.96 Very High Very High Very High
aspirin 8 87.60 High High
cINOD 2 83.48 Quite High
medulla 1 78.32 Quite High
Inflammation 2 48.88 Quite Low
ischemia 2 16.92 Low Low
Pain 7 5.00 Very Low Very Low Very Low
beta blocker 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 34 98.78 Very High Very High Very High
Increased Venous Pressure Under Development 6 97.40 Very High Very High Very High
INFLAMMATION 5 83.24 Quite High
Pathologic Constriction 3 79.56 Quite High
Peripheral Arterial Disease 61 77.96 Quite High
Ventricular Remodeling 2 68.52 Quite High
Myocardial Infarction 9 64.76 Quite High
Cardiomyopathy 1 62.80 Quite High
Heart Rate Under Development 6 60.00 Quite High
Left Ventricular Dysfunction 1 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In animal models, ACE-I can retard the development of atherosclerosis, and these antiatherogenic properties can be related to the inhibition of angiotensin-II (Ang II) formation and to the inhibition of bradykinin degradation, which promotes vasodilatation by stimulating the production of arachidonic acid metabolites and nitric oxide (NO) in vascular endothelium.
Negative_regulation (inhibition) of Localization (formation) of angiotensin-II in vascular endothelium associated with atherosclerosis, increased venous pressure under development and bradykinin
1) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.96 Pain Relevance 0.15
In the isolated perfused rabbit kidney, indomethacin inhibited the basal efflux of all fatty acids as well as the angiotensin II--induced selective release off arachidonate.
Negative_regulation (inhibited) of Localization (release) of angiotensin II in kidney
2) Confidence 0.09 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7465862 Disease Relevance 0.13 Pain Relevance 0.34

General Comments

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