INT47651

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 7.85
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (DERL2)
Anatomy Link Frequency
spindle cells 2
DERL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 1 88.64 High High
Inflammation 95 87.72 High High
cytokine 217 78.44 Quite High
chemokine 60 66.04 Quite High
metalloproteinase 204 44.32 Quite Low
COX-2 inhibitor 46 14.32 Low Low
iatrogenic 20 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 2 100.00 Very High Very High Very High
Herpes Simplex Virus 486 99.98 Very High Very High Very High
Infection 1048 99.60 Very High Very High Very High
Sarcoma 1133 99.22 Very High Very High Very High
Contagious Ecthyma 309 98.12 Very High Very High Very High
Cancer 190 97.28 Very High Very High Very High
Renal Disease 1 94.92 High High
Necrosis 5 93.52 High High
Thyroid Neoplasm 2 91.16 High High
Thyroid Nodule 1 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carcinoma-related protein production may have played a role in the development of the observed renal lesions.
Gene_expression (production) of Carcinoma-related associated with carcinoma
1) Confidence 0.68 Published 1981 Journal Urology Section Abstract Doc Link 7467024 Disease Relevance 0.89 Pain Relevance 0.09
IFA methods incorporate virally-infected cell lines, either latently infected with expression of LANA1, or cells that express lytic antigens following chemical induction (i.e., those representing viral replication).
Gene_expression (expression) of LANA1
2) Confidence 0.12 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.37 Pain Relevance 0
Studies have since shown that LANA1 is a 222–234 kDa protein that is expressed in the majority of nuclei in KS spindle cells [211,212]; however, the LANA1 protein expression is variable [211] and can depend upon the clinical stage of the KS tumor [213].
Gene_expression (expressed) of LANA1 in spindle cells associated with sarcoma and cancer
3) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.29 Pain Relevance 0
The antigenicity of the recombinant LANA1 protein has been shown by Western blot; over 70% of HHV-8 IFA seropositive sera were LANA1 positive in the Western blot [210,211].

7.B.

Gene_expression (positive) of LANA1
4) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.40 Pain Relevance 0
Studies have since shown that LANA1 is a 222–234 kDa protein that is expressed in the majority of nuclei in KS spindle cells [211,212]; however, the LANA1 protein expression is variable [211] and can depend upon the clinical stage of the KS tumor [213].
Gene_expression (expression) of LANA1 in spindle cells associated with sarcoma and cancer
5) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.27 Pain Relevance 0
It has also been reported that LANA1 (Orf73), because of its large size (>200 kDa) is expressed better in insect cells (personal communication, Dr.
Gene_expression (expressed) of LANA1
6) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.65 Pain Relevance 0
Fold inductions for COX-2 and m-PGES-1 in HMVEC-d (5d inf.) cells with about 50–60% infection and TIVE-LTC cells expressing LANA in 50–60% of the cells were comparable.
Gene_expression (expressing) of LANA associated with infection
7) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.09 Pain Relevance 0.06
During latency, KSHV expresses a battery of genes such as ORF73 (LANA-1), ORF72 (vCyclin), ORF71 (K13/vFLIP), and ORFK12 (Kaposin A, B and C), as well as 12 distinct miRNAs.
Gene_expression (expresses) of LANA associated with herpes simplex virus
8) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.89 Pain Relevance 0.22

General Comments

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