INT47662

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Context Info
Confidence 0.81
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 22.63
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
myocardium 3
ganglion 2
plasma 1
spinal 1
follicles 1
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
trigeminal ganglion 6 100.00 Very High Very High Very High
Angina 288 99.74 Very High Very High Very High
Pain 20 98.00 Very High Very High Very High
withdrawal 1 96.72 Very High Very High Very High
Neuropeptide 3 95.40 Very High Very High Very High
cva 58 92.88 High High
imagery 70 92.68 High High
headache 2 85.24 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Chills 10 99.92 Very High Very High Very High
Ectopic Pregnancy 190 99.80 Very High Very High Very High
Cv General 3 Under Development 65 99.74 Very High Very High Very High
Tubal Pregnancy 20 99.64 Very High Very High Very High
Infarction 40 99.54 Very High Very High Very High
Myocardial Infarction 485 99.52 Very High Very High Very High
Necrosis 188 99.50 Very High Very High Very High
Cv Unclassified Under Development 117 99.48 Very High Very High Very High
Fever 11 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The time to CK plateau (completion of infarction) was related to total CK release in both propranolol and comparison patients.
Localization (release) of CK associated with infarction
1) Confidence 0.81 Published 1981 Journal Chest Section Abstract Doc Link 7471859 Disease Relevance 0.42 Pain Relevance 0
Myocardial CK release in the propranolol group was 2651 mIU/ml +/- 843 (mean +/- SE, n = 12) vs 2987 mIU/ml +/- 422 in 21 comparison patients, a difference not statistically significant.
Localization (release) of CK
2) Confidence 0.81 Published 1981 Journal Chest Section Abstract Doc Link 7471859 Disease Relevance 0.35 Pain Relevance 0
Immunohistochemical evidence is provided for (i) the occurrence of a primary sensory neuronal population immunoreactive to methionine- and leucine-enkephalin (EK) in the human trigeminal ganglion; (ii) colocalization of EK and substance P (SP) in a subpopulation of ganglion neurones and in nerve fibres and terminal-like structures in the human trigeminal spinal nucleus.
Localization (colocalization) of EK in ganglion associated with ganglion cysts, trigeminal ganglion, enkephalin and substance p
3) Confidence 0.77 Published 1994 Journal Neuroreport Section Abstract Doc Link 7516198 Disease Relevance 0.27 Pain Relevance 0.83
The results obtained indicate that part of the EK-positive innervation of the spinal nucleus may be of ganglionic origin and raise the possibility that EK and SP are co-stored in and co-released from primary afferent terminals, thus adding to the complexity of the sites and ways of interaction between these neuropeptides in the processing of sensory information.
Localization (released) of EK in spinal associated with neuropeptide, enkephalin and substance p
4) Confidence 0.77 Published 1994 Journal Neuroreport Section Abstract Doc Link 7516198 Disease Relevance 0.25 Pain Relevance 0.84
CK release after embolization has been reported in only a few cases with endocrine tumors, which might indicate some relationship between active energy metabolism and mitochondrial CK.
Localization (release) of CK associated with cancer
5) Confidence 0.77 Published 2000 Journal Intern. Med. Section Abstract Doc Link 10852167 Disease Relevance 0.76 Pain Relevance 0.07
Ischemic preconditioning by unstable angina reduces the release of CK-MB following CABG and stimulates left ventricular HSP-72 protein expression.
Localization (release) of CK associated with angina
6) Confidence 0.76 Published 2005 Journal J Card Surg Section Title Doc Link 16153270 Disease Relevance 0.19 Pain Relevance 0.19
The effect of IP on the CABG induced maximal release of creatine kinase (CK) and CK-MB was examined.
Localization (release) of CK
7) Confidence 0.76 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
CK-MB release for any given cross-clamp time was significantly reduced by IP (regression lines: CON, y= 0.4x+ 2, r= 0.8; IP, y= 0.1x+ 10, r= 0.2; p < 0.01, ANCOVA).
Localization (release) of CK
8) Confidence 0.76 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
Immunohistochemical evidence is provided for (i) the occurrence of a primary sensory neuronal population immunoreactive to methionine- and leucine-enkephalin (EK) in the human trigeminal ganglion; (ii) colocalization of EK and substance P (SP) in a subpopulation of ganglion neurones and in nerve fibres and terminal-like structures in the human trigeminal spinal nucleus.
Localization (colocalization) of EK in ganglion associated with ganglion cysts, trigeminal ganglion, enkephalin and substance p
9) Confidence 0.72 Published 1994 Journal Neuroreport Section Abstract Doc Link 7516198 Disease Relevance 0.27 Pain Relevance 0.83
The effect of IP on the CABG induced maximal release of creatine kinase (CK) and CK-MB was examined.
Localization (release) of CK
10) Confidence 0.71 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
Specifically larger proteins such as CK are first taken up by lymphatic vessels, where their release into blood plasma is delayed by the relatively slow fluid movement of the system.
Localization (release) of CK in plasma
11) Confidence 0.68 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0 Pain Relevance 0
Enzymatic infarction size as expressed by sum of CK release had a significant negative correlation (R= ?
Localization (release) of CK associated with infarction
12) Confidence 0.58 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852768 Disease Relevance 0.20 Pain Relevance 0
The two visual grades were assessed along with enzymatic infarct size as creatine kinase release (CK), echocardiographic left ventricular ejection fraction (LVEF), and ST-segment resolution (STR) in 62 patients with acute myocardial infarction and successful revascularization.


Localization (release) of CK associated with myocardial infarction
13) Confidence 0.58 Published 2009 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2852768 Disease Relevance 0.31 Pain Relevance 0
CK and CK-MB exhibit a release pattern during MI that is characteristic of a functionally unbound, cytosolic protein, which is strongly dependent on perfusion in the infarct zone [11].
Localization (release) of CK associated with myocardial infarction
14) Confidence 0.58 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59629 Disease Relevance 0.58 Pain Relevance 0
CK and CK-MB exhibit a release pattern during MI that is characteristic of a functionally unbound, cytosolic protein, which is strongly dependent on perfusion in the infarct zone [11].
Localization (release) of CK-MB associated with myocardial infarction
15) Confidence 0.58 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59629 Disease Relevance 0.58 Pain Relevance 0
CK-MB is less abundant in the myocardium on a weight basis (with small amounts normally present in the circulation), but is cleared more rapidly than troponin T or I.
Localization (cleared) of CK-MB in myocardium
16) Confidence 0.58 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59629 Disease Relevance 0.36 Pain Relevance 0
No significant difference was observed in the median CK values associated with normal pregnancies or threatened abortion when compared to asymptomatic or symptomatic tubal pregnancies, suggesting that serum CK is not a useful biochemical marker for EP diagnosis.43
Localization (serum) of CK associated with tubal pregnancy, threatened abortion and ectopic pregnancy
17) Confidence 0.45 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.30 Pain Relevance 0.08
No significant difference was observed in the median CK values associated with normal pregnancies or threatened abortion when compared to asymptomatic or symptomatic tubal pregnancies, suggesting that serum CK is not a useful biochemical marker for EP diagnosis.43
Localization (marker) of CK associated with tubal pregnancy, threatened abortion and ectopic pregnancy
18) Confidence 0.45 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.31 Pain Relevance 0.08
Creatine kinase (CK) and CK-MB were elevated to 289 U/L (reference range, 0–225) and 28.7 ?
Localization (Creatine kinase) of CK
19) Confidence 0.42 Published 2003 Journal BMC Infect Dis Section Body Doc Link PMC183865 Disease Relevance 0.90 Pain Relevance 0.13
On the second day in hospital, CK normalized but troponin I remained elevated at 14.4 ?
Localization (normalized) of CK
20) Confidence 0.42 Published 2003 Journal BMC Infect Dis Section Body Doc Link PMC183865 Disease Relevance 0.83 Pain Relevance 0.14

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