INT4768

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2011
Negated 11
Speculated 7
Reported most in Abstract
Documents 212
Total Number 219
Disease Relevance 31.09
Pain Relevance 164.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
brain 9
lymphocytes 5
plasma 5
lateral 4
neurons 4
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 5248 100.00 Very High Very High Very High
Morphine 1466 100.00 Very High Very High Very High
Opioid 1352 100.00 Very High Very High Very High
agonist 1134 100.00 Very High Very High Very High
narcan 1116 100.00 Very High Very High Very High
mu opioid receptor 896 100.00 Very High Very High Very High
Enkephalin 277 100.00 Very High Very High Very High
opiate 249 100.00 Very High Very High Very High
Potency 109 100.00 Very High Very High Very High
Nucleus accumbens 41 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 11 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 41 99.82 Very High Very High Very High
INFLAMMATION 159 99.68 Very High Very High Very High
Urological Neuroanatomy 124 99.68 Very High Very High Very High
Diabetes Mellitus 7 99.68 Very High Very High Very High
Neuroblastoma 90 99.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

301 99.58 Very High Very High Very High
Inflammatory Pain 29 99.12 Very High Very High Very High
Suicidal Behaviour 6 98.96 Very High Very High Very High
Pheochromocytoma 156 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of MOR1K activation on cAMP, Ca2+ and NO levels
Positive_regulation (activation) of MOR1K
1) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0 Pain Relevance 0.55
In contrast to MOR1, activation of MOR1K with morphine produced a substantial dose-dependent increase in NO that was blocked by naloxone (Fig. 3A).
Positive_regulation (activation) of MOR1K associated with narcan and morphine
2) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0 Pain Relevance 1.05
It is known that stimulation of the MOR1 leads to the dissociation of the heterotrimeric G?
Positive_regulation (stimulation) of MOR1
3) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0 Pain Relevance 0.56
Taken together, these findings suggest that activation of constitutively expressed MOR inhibits microglial cell chemotaxis and support the notion of an anti-inflammatory role of MOR within the brain.
Positive_regulation (activation) of MOR in brain associated with inflammation and mu opioid receptor
4) Confidence 0.70 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152411 Disease Relevance 0.17 Pain Relevance 0.66
The activation of the mu-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements.
Positive_regulation (activation) of mu-opioid receptor associated with pain and opioid receptor
5) Confidence 0.70 Published 2001 Journal Science Section Abstract Doc Link 11452128 Disease Relevance 0.53 Pain Relevance 1.19
This deactivation was reflected by increases in mu-opioid receptor availability in vivo.
Positive_regulation (increases) of mu-opioid receptor
6) Confidence 0.70 Published 2003 Journal Arch. Gen. Psychiatry Section Body Doc Link 14609890 Disease Relevance 0 Pain Relevance 0
In contrast to stimulation of MOR1, stimulation of MOR1K leads to increased Ca2+ levels as well as increased nitric oxide (NO) release.
Positive_regulation (stimulation) of MOR1K
7) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link 20525224 Disease Relevance 0.08 Pain Relevance 0
Similar results of mu opioid receptor activation were observed when monkey lymphocytes were treated with morphine.
Positive_regulation (activation) of mu opioid receptor in lymphocytes associated with mu opioid receptor and morphine
8) Confidence 0.69 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11118335 Disease Relevance 0 Pain Relevance 0.70
In mu-opioid receptor stably transfected human embryonic kidney 293 (HEK-mu) cells, morphine treatment produced cAMP upregulation, yet failed to induce mu-opioid receptor tolerance.
Neg (failed) Positive_regulation (induce) of mu-opioid receptor in embryonic kidney associated with tolerance, opioid receptor and morphine
9) Confidence 0.69 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688980 Disease Relevance 0.07 Pain Relevance 1.35
In conclusion, different opioid ligands can differentially affect Ca(2+) response patterns resulting from MOR activation.
Positive_regulation (activation) of MOR associated with opioid
10) Confidence 0.69 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183657 Disease Relevance 0 Pain Relevance 0.88
In contrast, chronic exposure to the opioid peptides endomorphin-1 or endomorphin-2 significantly increased MOR mRNA levels in undifferentiated and RA-differentiated cells.
Positive_regulation (increased) of MOR mRNA associated with rheumatoid arthritis, opioid receptor and opioid
11) Confidence 0.68 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.52 Pain Relevance 1.10
Differentiation of SHSY-5Y cells with either retinoic acid (RA) or 12-o-tetradecanoyl-phorbol-13-acetate (TPA) significantly increased MOR mRNA levels.
Positive_regulation (increased) of MOR mRNA associated with rheumatoid arthritis and opioid receptor
12) Confidence 0.68 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.50 Pain Relevance 0.90
Mu-opioid receptor activation in live cells.
Positive_regulation (activation) of Mu-opioid receptor associated with opioid receptor
13) Confidence 0.67 Published 2008 Journal FASEB J. Section Title Doc Link 18587007 Disease Relevance 0 Pain Relevance 0.84
Sequestration and rapid down-regulation of the mu-opioid receptor were induced by DAGO and etorphine but not morphine.
Neg (not) Positive_regulation (induced) of mu-opioid receptor associated with opioid receptor, morphine and immobilon
14) Confidence 0.65 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9350996 Disease Relevance 0 Pain Relevance 0.74
PHA stimulation increased activation of the MOR promoter as well as levels of MOR mRNA, total receptor protein in cell lysates, and surface and cytoplasmic receptor expression.
Positive_regulation (activation) of MOR associated with mu opioid receptor
15) Confidence 0.62 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.35 Pain Relevance 0.76
PHA stimulation increased activation of the MOR promoter as well as levels of MOR mRNA, total receptor protein in cell lysates, and surface and cytoplasmic receptor expression.
Positive_regulation (activation) of MOR associated with mu opioid receptor
16) Confidence 0.62 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.35 Pain Relevance 0.75
In search of proteins regulating the mu-opioid receptor endocytosis, we have recently established that activation of phospholipase D (PLD)2 is required for agonist-induced mu-opioid receptor endocytosis.
Positive_regulation (induced) of mu-opioid receptor associated with agonist and opioid receptor
17) Confidence 0.61 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.49
Results show that stimulation of MOR1K with morphine leads to excitatory cellular effects.
Positive_regulation (stimulation) of MOR1K
18) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link 20525224 Disease Relevance 0.08 Pain Relevance 0
Conversely, a significant increase in mu-opioid receptor BP was observed in healthy control subjects in the rostral region of the anterior cingulate.
Positive_regulation (increase) of mu-opioid receptor in anterior
19) Confidence 0.61 Published 2006 Journal Arch. Gen. Psychiatry Section Body Doc Link 17088500 Disease Relevance 0 Pain Relevance 0
These results support the hypothesis that a spinal dynorphin/kappa opiate receptor system is activated during gestation.
Positive_regulation (activated) of opiate receptor in spinal associated with dynorphin and opiate
20) Confidence 0.60 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2565243 Disease Relevance 0 Pain Relevance 0.68

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