INT47680

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2011
Negated 9
Speculated 13
Reported most in Abstract
Documents 92
Total Number 105
Disease Relevance 41.61
Pain Relevance 53.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 39
hippocampus 16
DRG 16
neurons 8
spinal cord 6
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 974 100.00 Very High Very High Very High
bDMF 692 100.00 Very High Very High Very High
fluoxetine 458 100.00 Very High Very High Very High
Hippocampus 391 100.00 Very High Very High Very High
long-term potentiation 317 100.00 Very High Very High Very High
Pain 212 100.00 Very High Very High Very High
sSRI 158 100.00 Very High Very High Very High
Nerve growth factor 82 100.00 Very High Very High Very High
Neuropathic pain 61 100.00 Very High Very High Very High
monoamine 38 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 284 100.00 Very High Very High Very High
Stress 156 100.00 Very High Very High Very High
Neuropathic Pain 133 100.00 Very High Very High Very High
INFLAMMATION 117 100.00 Very High Very High Very High
Convulsion 29 100.00 Very High Very High Very High
Nervous System Injury 19 100.00 Very High Very High Very High
Peripheral Neuropathy 5 99.86 Very High Very High Very High
Ganglion Cysts 125 99.84 Very High Very High Very High
Stroke 95 99.82 Very High Very High Very High
Aids-related Complex 85 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real time RT-PCR studies revealed minimal changes in the expression of BDNF in the spinal cord after CCI despite the strain considered, but marked changes in dorsal root ganglia (DRG) were observed.
Regulation (changes) of Gene_expression (expression) of BDNF in dorsal root ganglia associated with eae, sprains and strains and spinal cord
1) Confidence 0.62 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17556103 Disease Relevance 1.23 Pain Relevance 0.96
Since brain-derived neutrophic factor (BDNF) modulates both the endogenous opioid and noradrenergic systems, we have now studied specific changes in BDNF gene expression related to the maintenance of neuropathic pain in the three rat strains.
Regulation (changes) of Gene_expression (expression) of BDNF in brain associated with neuropathic pain, endogenous opioid and sprains and strains
2) Confidence 0.62 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17556103 Disease Relevance 1.14 Pain Relevance 0.88
Changes in BDNF gene expression correlate with rat strain differences in neuropathic pain.
Regulation (Changes) of Gene_expression (expression) of BDNF associated with pain, neuropathic pain and sprains and strains
3) Confidence 0.62 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17556103 Disease Relevance 1.10 Pain Relevance 1.05
Since alterations in BDNF gene expression in higher brain centers may be relevant to cognitive changes that occur in recurrent depression, these results may provide insights into the coincidence of chronic pain and depression.
Regulation (alterations) of Gene_expression (expression) of BDNF gene in brain associated with cognitive disorder, depression and lasting pain
4) Confidence 0.62 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 1.04 Pain Relevance 0.66
Bi-phasic change in BDNF gene expression following antidepressant drug treatment.
Regulation (change) of Gene_expression (expression) of BDNF associated with antidepressant
5) Confidence 0.62 Published 2003 Journal Neuropharmacology Section Title Doc Link 12726822 Disease Relevance 0 Pain Relevance 0.90
This study aimed to clarify the influence of post drug interval on the effect of acute and repeated treatment with antidepressant drugs on BDNF gene expression in the rat brain.
Regulation (effect) of Gene_expression (expression) of BDNF in brain associated with antidepressant and bdmf
6) Confidence 0.62 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 0.71
It was found that repeated administration of either the monoamine oxidase inhibitor tranylcypromine (TCP) or 5-hydroxytryptamine (5-HT) re-uptake inhibitors (fluoxetine, paroxetine and sertraline), evoke a bi-phasic and time-dependent effect on BDNF gene expression in the rat hippocampus (especially dentate gyrus).
Regulation (effect) of Gene_expression (expression) of BDNF in hippocampus associated with hippocampus, bdmf, fluoxetine and monoamine
7) Confidence 0.62 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 1.01
Conversely, although imipramine did not provide significant behavioral analgesia, it significantly blocked both pain- and stress-evoked alterations in hippocampal and spinal NK-1 and BDNF gene expression.
Regulation (alterations) of Gene_expression (expression) of BDNF gene in spinal associated with stress, pain and analgesia
8) Confidence 0.62 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.21 Pain Relevance 1.56
Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat.
Regulation (Effects) of Gene_expression (expression) of brain-derived neurotrophic factor in brain associated with stress, pain, antidepressant and analgesic
9) Confidence 0.62 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16956981 Disease Relevance 1.28 Pain Relevance 1.61
Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation.
Regulation (change) of Gene_expression (expression) of BDNF associated with antidepressant
10) Confidence 0.61 Published 2006 Journal Brain Res. Section Title Doc Link 16842762 Disease Relevance 0.09 Pain Relevance 0.27
In previous studies, an enriched environment (24), or motor balance and coordination training (7), influenced the expression of BDNF or synaptophysin in some brain regions, but not in other regions.
Regulation (influenced) of Gene_expression (expression) of BDNF in brain
11) Confidence 0.61 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.19 Pain Relevance 0.13
Further investigations are required to understand the effect of exercise or motor skill training on the expression of BDNF, an important modulator of synaptogenesis in the hippocampus, in ischemic stroke rats.
Regulation (effect) of Gene_expression (expression) of BDNF in hippocampus associated with stroke and hippocampus
12) Confidence 0.61 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.23 Pain Relevance 0.15
Dysregulation of BDNF synthesis and Arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and Alzheimer's disease.
Regulation (Dysregulation) of Gene_expression (synthesis) of BDNF in dentate gyrus associated with cognitive disorder, depression, aids-related complex and disease
13) Confidence 0.61 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.89 Pain Relevance 0.11
Therefore, we investigated the effects of immobilization stress or inflammatory stimuli on NK-1 receptor and BDNF gene expression in the rat hippocampus.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of BDNF in hippocampus associated with stress, hippocampus and inflammatory stimuli
14) Confidence 0.61 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 1.19 Pain Relevance 0.65
The present study aimed to investigate changes in the expression of BDNF and its receptor tyrosine kinase receptor B (TrkB) in the amygdala and the rostral ventromedial medulla (RVM) after NMS and colorectal distention (CRD) stimulation in rats.
Spec (investigate) Regulation (changes) of Gene_expression (expression) of BDNF in RVM associated with neuroleptic malignant syndrome, amygdala and rostral ventromedial medulla
15) Confidence 0.61 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.04 Pain Relevance 0.51
Our results indicate that the expression of BDNF mRNA isoforms is not affected by chronic or acute treatment with fluoxetine or GR205171.
Neg (not) Regulation (affected) of Gene_expression (expression) of BDNF associated with fluoxetine
16) Confidence 0.60 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053962 Disease Relevance 0.16 Pain Relevance 0.40
Chronic morphine treatment significantly increased the expression of exon I and IV BDNF transcripts, indicating differential regulation of BDNF gene expression.
Regulation (regulation) of Gene_expression (expression) of BDNF gene associated with morphine
17) Confidence 0.59 Published 2009 Journal Neuroreport Section Abstract Doc Link 19033880 Disease Relevance 0 Pain Relevance 1.07
We discuss the way that current and future treatment development can be guided by our growing understanding of this molecule's actions in the brain and the ways the expression of BDNF can be regulated.
Regulation (regulated) of Gene_expression (expression) of BDNF in brain
18) Confidence 0.59 Published 2003 Journal Semin Clin Neuropsychiatry Section Abstract Doc Link 12728410 Disease Relevance 0.57 Pain Relevance 0.13
This study addressed whether estrogen regulates BDNF gene expression in central systems associated with nociceptive processing and/or affective state, which may in turn influence sex differences in pain sensitivity.
Spec (whether) Regulation (regulates) of Gene_expression (expression) of BDNF gene associated with nociception and pain
19) Confidence 0.54 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 1.11 Pain Relevance 0.51
To investigate the effect of estrogen on BDNF expression in neuropathic pain.
Spec (investigate) Regulation (effect) of Gene_expression (expression) of BDNF associated with neuropathic pain
20) Confidence 0.54 Published 2003 Journal Neuroreport Section Abstract Doc Link 14502089 Disease Relevance 0.35 Pain Relevance 0.23

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