INT47681

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 3.61
Pain Relevance 6.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
brain 3
dorsal 1
arms 1
internal 1
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 8 100.00 Very High Very High Very High
antidepressant 492 99.86 Very High Very High Very High
fluoxetine 88 99.84 Very High Very High Very High
bDMF 64 99.64 Very High Very High Very High
agonist 31 98.72 Very High Very High Very High
midbrain 6 98.60 Very High Very High Very High
Raphe 14 96.76 Very High Very High Very High
depression 210 95.96 Very High Very High Very High
Nucleus accumbens 16 94.08 High High
Eae 46 93.64 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 15 99.88 Very High Very High Very High
Depression 238 98.80 Very High Very High Very High
Convulsion 13 98.08 Very High Very High Very High
Nociception 2 97.92 Very High Very High Very High
Arthritis 2 97.56 Very High Very High Very High
Injury 69 93.80 High High
Disease 25 93.40 High High
Hyperalgesia 2 83.52 Quite High
Stress 34 77.44 Quite High
Pain 10 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain.
Regulation (regulation) of TrkB in brain associated with nociceptor
1) Confidence 0.62 Published 1997 Journal Exp. Neurol. Section Title Doc Link 9184109 Disease Relevance 0.14 Pain Relevance 0.49
In order to investigate ligand-mediated regulation of TrkB in vivo, we infused BDNF into the midbrain, near the periaquaductal grey-dorsal raphe (PAG-DR), or into the olfactory bulb of adult rats.
Regulation (regulation) of TrkB in dorsal associated with urological neuroanatomy, midbrain and raphe
2) Confidence 0.62 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.10 Pain Relevance 0.30
Effects of trkB and trkC neurotrophin receptor agonists on thermal nociception: a behavioral and electrophysiological study.
Regulation (Effects) of trkB associated with nociception, nociceptor and agonist
3) Confidence 0.36 Published 1999 Journal Pain Section Title Doc Link 10342408 Disease Relevance 0.25 Pain Relevance 0.75
AIM: To investigate the effects of corticotrophin (Cor) on corticotropin-releasing factor (CRF), brain-derived neurotrophic factor (BDNF), and its functional receptor trkB in the frontal cortex of complete Freud's adjuvant (CFA)-induced arthritic rats.
Spec (investigate) Regulation (effects) of trkB in brain associated with urological neuroanatomy and arthritis
4) Confidence 0.34 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11360665 Disease Relevance 0.42 Pain Relevance 0.15
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.
Regulation (Regulation) of trkB in brain associated with antidepressant and convulsion
5) Confidence 0.19 Published 1995 Journal J. Neurosci. Section Title Doc Link 7472505 Disease Relevance 0.95 Pain Relevance 0.17
In contrast, striatal levels of trkB mRNA were not significantly affected by BDNF administration.
Neg (not) Regulation (affected) of trkB mRNA
6) Confidence 0.12 Published 1994 Journal Neuroreport Section Abstract Doc Link 8025254 Disease Relevance 0 Pain Relevance 0.20
BDNF and its receptor TrkB are modulated by drugs of other pharmacological classes.
Regulation (modulated) of TrkB associated with bdmf
7) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.23 Pain Relevance 0.78
Nonetheless, a deeper understanding of combinatorial (or synergistic) effects of various arms of the BDNF signaling cascade may be essential to deciphering new key aspects of gene regulation via BDNF and TrkB in striatal cells.
Regulation (regulation) of TrkB in arms
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.07
Biarylpropylsulfonamide AMPA receptor potentiator (LY404187) and its active isomer (LY451646) showed a dose and time-dependent modulation of BDNF and TrkB mRNA expression [180].
Regulation (modulation) of TrkB
9) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.25 Pain Relevance 0.62
The aim of this study was to investigate the influence of medical factors and functioning on sick listing probability.


Spec (investigate) Regulation (influence) of factors
10) Confidence 0.03 Published 2008 Journal BMC Fam Pract Section Abstract Doc Link PMC2266928 Disease Relevance 0.19 Pain Relevance 0
The relative homogeneity of the participants in educational attainment and occupation, and the fact that we were able to control for a series of background factors, served to enhance the internal validity of the study.
Regulation (control) of factors in internal
11) Confidence 0.03 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0.07 Pain Relevance 0
The transcriptional regulation exerted by differentially expressed transcription factors
Regulation (regulation) of factors
12) Confidence 0.00 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.16 Pain Relevance 0.12
All four classes of antidepressants, tested in our study, antagonistically reversed strong up or down regulation of growth factors, induced by PMA in cultured SY5Y cells [15,20].
Regulation (regulation) of factors associated with antidepressant
13) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.22 Pain Relevance 0.29
In this study, antidepressant treatments are analyzed in a cell culture system, to study the modulation of growth factors.


Regulation (modulation) of factors associated with antidepressant
14) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2275236 Disease Relevance 0.18 Pain Relevance 0.37
Reboxetine worked in an exactly opposite way on the transcription of growth factors, by strongly increasing down regulated factors and modestly reducing up regulated factors.
Regulation (regulated) of factors
15) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.44
Growth factors became strongly up or down regulated in PMA-treated SY5Y cells during cultivation.
Regulation (regulated) of factors
16) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.07 Pain Relevance 0.30
Antidepressant drugs modulate growth factors in cultured cells

Background

Regulation (modulate) of factors associated with antidepressant
17) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Title Doc Link PMC2275236 Disease Relevance 0.19 Pain Relevance 0.38
The antagonistic regulation of growth factors was a common property of all antidepressant classes; however, there were differences in kinetics and specificity.
Regulation (regulation) of factors associated with antidepressant
18) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.07 Pain Relevance 0.48
Reboxetine worked in an exactly opposite way on the transcription of growth factors, by strongly increasing down regulated factors and modestly reducing up regulated factors.
Regulation (regulated) of factors
19) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.05 Pain Relevance 0.41

General Comments

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