INT47682

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 6.32
Pain Relevance 8.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
nerve 2
tooth 2
hippocampus 2
dorsal 1
pyramidal cell 1
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 6 100.00 Very High Very High Very High
peripheral neuropathy 5 99.86 Very High Very High Very High
Somatostatin 6 99.84 Very High Very High Very High
antidepressant 301 99.70 Very High Very High Very High
Trigeminal ganglion neurons 4 99.68 Very High Very High Very High
Calcitonin gene-related peptide 4 99.56 Very High Very High Very High
Glutamate 39 99.18 Very High Very High Very High
tramadol 7 98.98 Very High Very High Very High
Hippocampus 100 98.96 Very High Very High Very High
tetrodotoxin 3 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 5 99.86 Very High Very High Very High
Tooth Injuries 8 99.84 Very High Very High Very High
Ganglion Cysts 11 99.24 Very High Very High Very High
Convulsion 27 98.74 Very High Very High Very High
Apoptosis 27 98.12 Very High Very High Very High
Depression 129 94.16 High High
Neuropathic Pain 2 92.84 High High
Pain 32 89.12 High High
INFLAMMATION 18 88.72 High High
Injury 69 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to characterize the impact of tooth injury on the distribution of tyrosine receptor kinase B (TrkB) among trigeminal ganglion neurons and assess the time course for tooth injury-induced TrkB distribution changes.
Transcription (distribution) of TrkB in tooth associated with ganglion cysts, tooth injuries and trigeminal ganglion neurons
1) Confidence 0.69 Published 2003 Journal J Endod Section Abstract Doc Link 12597715 Disease Relevance 0.58 Pain Relevance 0.15
The purpose of this study was to characterize the impact of tooth injury on the distribution of tyrosine receptor kinase B (TrkB) among trigeminal ganglion neurons and assess the time course for tooth injury-induced TrkB distribution changes.
Transcription (distribution) of tyrosine receptor kinase B in tooth associated with ganglion cysts, tooth injuries and trigeminal ganglion neurons
2) Confidence 0.69 Published 2003 Journal J Endod Section Abstract Doc Link 12597715 Disease Relevance 0.57 Pain Relevance 0.15
To assess NTs in the NuGr in PN, mRNA expression of BDNF, nerve growth factor (NGF), and NT receptors TrkA, TrkB, and p75 was determined 1 week after ligation of L5 and L6 spinal nerves (SNL).
Spec (determined) Transcription (expression) of TrkB in nerve associated with nerve growth factor and peripheral neuropathy
3) Confidence 0.57 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144880 Disease Relevance 0.47 Pain Relevance 0.57
In contrast, there was no change in mRNA expression levels for neurotrophin-4/5, beta-nerve growth factor (beta-NGF), trkB, glial cell line-derived neurotrophin factor, and receptor protein tyrosine kinase protein.
Transcription (expression) of trkB in nerve associated with nerve growth factor
4) Confidence 0.55 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.51 Pain Relevance 0.33
However, tramadol when administered repeatedly did not increase the levels of mRNA encoding for brain-derived neurotrophic factor (BDNF) and its receptor, TrkB.
Transcription (levels) of TrkB in brain associated with tramadol
5) Confidence 0.51 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464068 Disease Relevance 0.08 Pain Relevance 0.97
The extracellular levels of glutamate in individual animals correlated to the levels of BDNF and trkB mRNAs in the dorsal CA1 region of the hippocampus.
Transcription (levels) of trkB in dorsal associated with glutamate and hippocampus
6) Confidence 0.51 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.70
Glutamate release correlates with brain-derived neurotrophic factor and trkB mRNA expression in the CA1 region of rat hippocampus.
Transcription (expression) of trkB in hippocampus associated with glutamate and hippocampus
7) Confidence 0.51 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.58
Levels of BDNF and trkB mRNAs were increased in the hippocampus in a dose-dependent fashion following the stimulations.
Transcription (Levels) of trkB in hippocampus associated with hippocampus
8) Confidence 0.51 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.71
A similar effect was observed in layer 2 of the piriform cortex, where chronic ECS significantly increased the acute induction and prolonged the expression of BDNF and trkB mRNA.
Transcription (expression) of trkB in piriform cortex associated with convulsion
9) Confidence 0.51 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.03 Pain Relevance 0.45
In CA3 and CA1 pyramidal cell layers, chronic ECS significantly elevated the acute induction of BDNF, and tended to prolong the expression of BDNF and trkB mRNA.
Transcription (expression) of trkB in pyramidal cell associated with convulsion and pyramidal cell
10) Confidence 0.51 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.98 Pain Relevance 0.36
In the control animals, beta-preprotachykinin, gamma-preprotachykinin, calcitonin gene-related peptide, somatostatin, trkA, trkB and trkC messenger RNAs were found in about 30%, 30%, 40%, 10%, 40%, 5% and 20% of the lumbar dorsal root ganglion neurons, respectively.
Transcription (found) of trkB in neurons associated with ganglion cysts, root ganglion neuron, somatostatin and calcitonin gene-related peptide
11) Confidence 0.44 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.19 Pain Relevance 0.81
P2Y13 receptors were coupled to the well characterized PI3K/Akt dependent pathway, described for growth factors of the insulin family [10], resulting in the stabilization of the GSK3 substrate ?
Transcription (described) of factors
12) Confidence 0.30 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.13 Pain Relevance 0.07
BDNF has been reported to activate transcription factors, such as CREB and NF?
Transcription (transcription) of factors
13) Confidence 0.30 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.24 Pain Relevance 0.03
Biarylpropylsulfonamide AMPA receptor potentiator (LY404187) and its active isomer (LY451646) showed a dose and time-dependent modulation of BDNF and TrkB mRNA expression [180].
Transcription (expression) of TrkB
14) Confidence 0.27 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.25 Pain Relevance 0.62
transcription factors [26, 27], enhances TGF-?
Transcription (transcription) of factors
15) Confidence 0.18 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.12 Pain Relevance 0.12
Subsequently, CREB phosphorylated at serine133 (p-CREB) further induces transcription of genes containing cAMP response element (CRE) binding sites in their promoter regions [31], such as c-fos, NK-1, BDNF, and trkB [32-34].
Transcription (transcription) of trkB
16) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.39 Pain Relevance 0.46
On the other hand, antidepressants increased the transcription of factors that became down regulated upon PMA-treatment.
Transcription (transcription) of factors associated with antidepressant
17) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.08 Pain Relevance 0.43
Reboxetine worked in an exactly opposite way on the transcription of growth factors, by strongly increasing down regulated factors and modestly reducing up regulated factors.
Transcription (transcription) of factors
18) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.47
In this study we analyzed the transcription of growth factors in cell culture systems.
Spec (analyzed) Transcription (transcription) of factors
19) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.23 Pain Relevance 0.24
We quantified the transcription of several growth factors in three cell lines after application of antidepressant drugs by real time polymerase chain reaction.
Transcription (transcription) of factors associated with antidepressant
20) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2275236 Disease Relevance 0.17 Pain Relevance 0.38

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