INT47683

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2011
Negated 0
Speculated 3
Reported most in Abstract
Documents 92
Total Number 102
Disease Relevance 47.53
Pain Relevance 43.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 20
hippocampus 6
neurons 6
spinal 4
cortex 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 1114 100.00 Very High Very High Very High
Spinal cord 458 100.00 Very High Very High Very High
depression 753 99.96 Very High Very High Very High
Calcium channel 8 99.96 Very High Very High Very High
c fibre 8 99.92 Very High Very High Very High
Migraine 5 99.92 Very High Very High Very High
fluoxetine 299 99.82 Very High Very High Very High
Desipramine 16 99.82 Very High Very High Very High
qutenza 9 99.74 Very High Very High Very High
Hippocampus 637 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 920 100.00 Very High Very High Very High
Hyperoxia 90 99.98 Very High Very High Very High
Depression 815 99.96 Very High Very High Very High
Headache 9 99.92 Very High Very High Very High
Nociception 107 99.84 Very High Very High Very High
Suicidal Behaviour 54 99.84 Very High Very High Very High
Targeted Disruption 84 99.78 Very High Very High Very High
Neuropathic Pain 186 99.68 Very High Very High Very High
Disease 147 99.68 Very High Very High Very High
Hypersensitivity 130 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cortical BDNF mRNA levels were significantly decreased by nociception, in the hippocampus this decrease was only evident in estrogen-treated rats.
Negative_regulation (decreased) of BDNF mRNA in hippocampus associated with nociception and hippocampus
1) Confidence 0.59 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 1.21 Pain Relevance 0.71
Four days of once daily oral administration of fluoxetine induced decreases in BDNF mRNA (hippocampus, medial habenular and paraventricular thalamic nuclei).
Negative_regulation (decreases) of BDNF in medial associated with hippocampus and fluoxetine
2) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.67
The highest dose of capsaicin also induced a depletion of BDNF protein in the dorsal horn.
Negative_regulation (depletion) of BDNF protein in dorsal horn associated with qutenza and dorsal horn
3) Confidence 0.59 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.80
Furthermore, chronic administration of ECS or antidepressant drugs completely blocked the down-regulation of BDNF mRNA in the hippocampus in response to restraint stress.
Negative_regulation (down-regulation) of BDNF mRNA in hippocampus associated with stress, antidepressant, convulsion and hippocampus
4) Confidence 0.59 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.80 Pain Relevance 0.51
However, the fact that neutralizing the increased BDNF induced by incision can reduce the mechanical allodynia following incision strongly suggest that inhibiting BDNF may be a new approach in the multimodal analgesia to treat post-operative pain.


Negative_regulation (inhibiting) of BDNF associated with pain, allodynia, balanced analgesia and bdmf
5) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.17 Pain Relevance 2.04
Acute or chronic stress can alter hippocampal structure, cause neuronal damage, and decrease hippocampal levels of the neurotrophin brain-derived neurotrophic factor (BDNF).
Negative_regulation (decrease) of BDNF in brain associated with stress
6) Confidence 0.58 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 0.59 Pain Relevance 0.33
The decrease in pain behavior and BDNF-IR, CRF mRNA levels in frontal cortex of arthritic rats due to Cor were partly prevented by adrenalectomy (ADX).
Negative_regulation (decrease) of BDNF-IR in frontal cortex
7) Confidence 0.57 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11360665 Disease Relevance 0.15 Pain Relevance 0
However, the brain-derived neurotrophic factor (BDNF) receptor TrkB decreased by 42.8+/-6%, and remained decreased after 6 weeks of treatment.
Negative_regulation (decreased) of brain-derived neurotrophic factor in brain
8) Confidence 0.57 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.55
BDNF levels were decreased by 45-65% in the presence of TTX or receptor antagonists and increased by 25% in elevated extracellular potassium.
Negative_regulation (decreased) of BDNF associated with antagonist
9) Confidence 0.51 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671864 Disease Relevance 0 Pain Relevance 0.32
Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus.
Negative_regulation (reduction) of BDNF in brain associated with stress, anxiety disorder and hippocampus
10) Confidence 0.51 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.67 Pain Relevance 0.05
To test this, we infused the cortex with an inhibitor of Trk receptor tyrosine kinases, anti-TrkB IgG1, anti-BDNF, and anti-neurotrophin 4/5 antibodies.
Negative_regulation (inhibitor) of anti-BDNF in cortex
11) Confidence 0.51 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736347 Disease Relevance 0.96 Pain Relevance 0.51
Following an acute injection, all three drugs tested: fluoxetine, desipramine and TCP decreased total BDNF mRNA (exon V) as well as exon IV mRNA, while no significant effect was recorded for exons I and III mRNAs.
Negative_regulation (decreased) of BDNF associated with desipramine and fluoxetine
12) Confidence 0.51 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.20 Pain Relevance 0.38
A reduction of brain-derived neurotrophic factor messenger RNA was observed in the visual cortex contralateral to the deprived eye in rats monocularly deprived during the critical period.
Negative_regulation (reduction) of brain-derived neurotrophic factor in eye
13) Confidence 0.50 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848102 Disease Relevance 0 Pain Relevance 0
Quantitative RNAase protection assays revealed that the cortical level of brain-derived neurotrophic factor messenger RNA was reduced to the same extent when intraocular injections of tetrodotoxin were performed within or after the critical period.
Negative_regulation (reduced) of brain-derived neurotrophic factor in brain associated with tetrodotoxin
14) Confidence 0.50 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848102 Disease Relevance 0 Pain Relevance 0.10
Our results suggest that the reduction of brain-derived neurotrophic factor messenger RNA induced by monocular deprivation is related to the absence of pattern vision rather than to the competitive interactions that underlie the effects of monocular deprivation during the critical period.
Negative_regulation (reduction) of brain-derived neurotrophic factor in brain
15) Confidence 0.50 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848102 Disease Relevance 0 Pain Relevance 0.08
Acute or chronic stress can alter hippocampal structure, cause neuronal damage, and decrease hippocampal levels of the neurotrophin brain-derived neurotrophic factor (BDNF).
Negative_regulation (decrease) of neurotrophin brain-derived neurotrophic factor in brain associated with stress
16) Confidence 0.50 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 0.59 Pain Relevance 0.33
The reduction in growth factors, such as BDNF, impacts negatively on the structural and functional processes within the limbic system, especially for the hippocampus.
Negative_regulation (reduction) of BDNF in hippocampus associated with hippocampus and limbic system
17) Confidence 0.49 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.14 Pain Relevance 0.51
Because BDNF levels are reduced in the brains of HD patients and HD mouse models, we sought to investigate whether Htt might be involved in the transport of BDNF mRNA through neuronal RNA granules.
Negative_regulation (reduced) of BDNF in brains associated with disease
18) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.20 Pain Relevance 0
Furthermore, the magnitude of the decrease in BDNF mRNA (?
Negative_regulation (decrease) of BDNF mRNA
19) Confidence 0.46 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.69 Pain Relevance 0.23
In all cases, blockade of ERK phosphorylation lead to downregulation of the contents of BDNF and NPY, correlating with improvement in pain hypersensitivity.
Negative_regulation (downregulation) of BDNF associated with hypersensitivity and stimulus evoked pain
20) Confidence 0.45 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.71 Pain Relevance 0.64

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