INT47685

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 32
Total Number 39
Disease Relevance 20.05
Pain Relevance 27.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
spinal cord 12
brain 10
prefrontal 4
spinal 4
sciatic nerve 4
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 1758 100.00 Very High Very High Very High
Hippocampus 208 100.00 Very High Very High Very High
Sciatic nerve 148 99.98 Very High Very High Very High
Nerve growth factor 108 99.98 Very High Very High Very High
nMDA receptor 53 99.98 Very High Very High Very High
Pain 340 99.88 Very High Very High Very High
Spinal cord 518 99.68 Very High Very High Very High
Neuropathic pain 114 99.54 Very High Very High Very High
Pyramidal cell 7 99.30 Very High Very High Very High
tramadol 7 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 336 100.00 Very High Very High Very High
Stress 291 100.00 Very High Very High Very High
Anxiety Disorder 89 100.00 Very High Very High Very High
Aids-related Complex 18 100.00 Very High Very High Very High
Nervous System Injury 103 99.98 Very High Very High Very High
Sciatic Neuropathy 32 99.98 Very High Very High Very High
Pain 539 99.88 Very High Very High Very High
Convulsion 57 99.70 Very High Very High Very High
Nociception 69 99.66 Very High Very High Very High
Neuropathic Pain 344 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transection of the sciatic nerve induced the up-regulation of BDNF mRNA.
Positive_regulation (induced) of Positive_regulation (regulation) of BDNF in sciatic nerve associated with sciatic nerve
1) Confidence 0.70 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.26 Pain Relevance 0.46
Significantly increased levels of BDNF were also observed after RN46A-B14 transplantation but were not localized to particular spinal laminae.
Positive_regulation (increased) of Positive_regulation (levels) of BDNF in spinal
2) Confidence 0.69 Published 2001 Journal Brain Res. Section Abstract Doc Link 11532245 Disease Relevance 0.18 Pain Relevance 0.37
Significantly increased levels of BDNF were also observed after RN46A-B14 transplantation but were not localized to particular spinal laminae.
Positive_regulation (levels) of Positive_regulation (increased) of BDNF in spinal
3) Confidence 0.69 Published 2001 Journal Brain Res. Section Abstract Doc Link 11532245 Disease Relevance 0.18 Pain Relevance 0.37
In CA3 and CA1 pyramidal cell layers, chronic ECS significantly elevated the acute induction of BDNF, and tended to prolong the expression of BDNF and trkB mRNA.
Positive_regulation (elevated) of Positive_regulation (induction) of BDNF in pyramidal cell associated with convulsion and pyramidal cell
4) Confidence 0.61 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.00 Pain Relevance 0.35
However, the fact that neutralizing the increased BDNF induced by incision can reduce the mechanical allodynia following incision strongly suggest that inhibiting BDNF may be a new approach in the multimodal analgesia to treat post-operative pain.


Positive_regulation (increased) of Positive_regulation (induced) of BDNF associated with pain, allodynia, balanced analgesia and bdmf
5) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.16 Pain Relevance 2.04
To further explore whether incision-induced BDNF upregulation is mediated by a specific effect in the related segments or unspecific effect in the whole spinal cord, the expression pattern of the BDNF in the thoracic segments was examined.
Spec (examined) Positive_regulation (induced) of Spec (examined) Positive_regulation (upregulation) of BDNF in spinal cord associated with bdmf and spinal cord
6) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.22 Pain Relevance 1.00
Like inflammatory pain and neuropathic pain, incisional pain also induced the upregulation of BDNF in the DRG and spinal cord in the present study.
Positive_regulation (induced) of Positive_regulation (upregulation) of BDNF in spinal cord associated with pain, ipn, neuropathic pain, bdmf and spinal cord
7) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.08 Pain Relevance 1.89
There was no significant alteration for BDNF-IR in the thoracic segments after surgical incision as compared with the sham-operation (Figure 1F and 1G) (Table 1) suggesting that the incision induced segmental BDNF upregulation in the spinal cord.


Positive_regulation (induced) of Positive_regulation (upregulation) of BDNF in spinal cord associated with bdmf and spinal cord
8) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.87
In contrast to the detected time dependent and biphasic response of the BDNF gene, activity-regulated, cytoskeletal-associated protein (Arc) mRNA showed a gradual increase during the 14-day course of treatment.
Positive_regulation (increase) of Positive_regulation (response) of BDNF associated with aids-related complex
9) Confidence 0.50 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0.10 Pain Relevance 0.67
Chronic social defeat stress has been shown to downregulate the mRNA levels of BDNF transcripts IV and VI in the mouse hippocampus, which is accompanied by significant increases in H3-K27 dimethylation at the promoter of exons IV and VI without changes in H3 acetylation status at the promoter of either exons IV or VI.7 This result taken together with our findings suggests that chromatin remodeling through histone modification could play an important role in stress-induced gene expression in vivo.
Positive_regulation (induced) of Positive_regulation (dimethylation) of BDNF in hippocampus associated with stress and hippocampus
10) Confidence 0.50 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.95 Pain Relevance 0.28
Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus.
Positive_regulation (induced) of Positive_regulation (enhancement) of BDNF in brain associated with stress, anxiety disorder and hippocampus
11) Confidence 0.50 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.74 Pain Relevance 0.05
Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus.
Positive_regulation (induced) of Positive_regulation (enhancement) of BDNF in brain associated with stress, anxiety disorder and hippocampus
12) Confidence 0.50 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.74 Pain Relevance 0.05
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Positive_regulation (induces) of Positive_regulation (activation) of BDNF/mTOR in plasma associated with hippocampus
13) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
Involvement of afferent nerve transmission in the incision-mediated BDNF upregulation
Positive_regulation (mediated) of Positive_regulation (upregulation) of BDNF in nerve associated with bdmf
14) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.14 Pain Relevance 0.93
However, tramadol when administered repeatedly did not increase the levels of mRNA encoding for brain-derived neurotrophic factor (BDNF) and its receptor, TrkB.
Neg (not) Positive_regulation (increase) of Neg (not) Positive_regulation (increase) of brain-derived neurotrophic factor in brain associated with tramadol
15) Confidence 0.43 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464068 Disease Relevance 0.08 Pain Relevance 0.97
In summary, conditioning sciatic nerve lesion induced the upregulation of BDNF in the DRG and in the injured spinal cord.
Positive_regulation (induced) of Positive_regulation (upregulation) of BDNF in sciatic nerve associated with spinal cord injury, sciatic nerve, bdmf and spinal cord
16) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.50 Pain Relevance 0.57
Stimulation of pre-synaptic nociceptive afferent fibres induces BDNF release and consequent activation of TrkB receptors leading to a post-synaptic excitability.
Positive_regulation (induces) of Positive_regulation (activation) of BDNF associated with nociception
17) Confidence 0.41 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589922 Disease Relevance 0.56 Pain Relevance 0.59
The present study demonstrated that incision induced the segmental upregulation of BDNF in the DRGs and spinal cords through afferent nerve transmission.
Positive_regulation (induced) of Positive_regulation (upregulation) of BDNF in spinal cords associated with bdmf
18) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.18 Pain Relevance 2.08
In the present study, incision also induced the increase of BDNF level in the ipsilateral lumbar segments but not that in the contralateral side or thoracic spinal cord suggesting the expression pattern of BDNF level in the spinal cord was similar to that of COX-2 or the cytokines.
Positive_regulation (induced) of Positive_regulation (increase) of BDNF in spinal cord associated with bdmf, cytokine and spinal cord
19) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.94 Pain Relevance 1.58
The present study showed that incision induced the segmental upregulation of BDNF in the DRG and spinal cord through somatic afferent nerve transmission, and the upregulated BDNF contributed to the pain hypersensitivity induced by surgical incision.



Positive_regulation (induced) of Positive_regulation (upregulation) of BDNF in nerve associated with hypersensitivity, stimulus evoked pain, bdmf and spinal cord
20) Confidence 0.40 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2492846 Disease Relevance 0.54 Pain Relevance 1.26

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