INT47687

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.42
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
pyramidal cell 2
brain 2
piriform cortex 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 52 99.98 Very High Very High Very High
tramadol 7 99.24 Very High Very High Very High
Pyramidal cell 2 98.26 Very High Very High Very High
Nucleus accumbens 1 90.56 High High
Desipramine 2 88.72 High High
Dopamine 3 88.60 High High
Endep 3 83.36 Quite High
Hippocampus 10 80.72 Quite High
Potency 1 75.00 Quite High
Morphine 2 72.24 Quite High
Disease Link Frequency Relevance Heat
Convulsion 26 99.02 Very High Very High Very High
Apoptosis 13 98.12 Very High Very High Very High
Stress 5 78.44 Quite High
Attention Deficit Hyperactivity Disorder 1 78.12 Quite High
Urological Neuroanatomy 2 74.40 Quite High
Depression 7 40.96 Quite Low
Suicidal Behaviour 1 33.68 Quite Low
Death 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Clinical Trials And Case Reports 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, tramadol when administered repeatedly did not increase the levels of mRNA encoding for brain-derived neurotrophic factor (BDNF) and its receptor, TrkB.
Neg (not) Positive_regulation (increase) of Transcription (levels) of TrkB in brain associated with tramadol
1) Confidence 0.45 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464068 Disease Relevance 0.08 Pain Relevance 0.97
A similar effect was observed in layer 2 of the piriform cortex, where chronic ECS significantly increased the acute induction and prolonged the expression of BDNF and trkB mRNA.
Positive_regulation (prolonged) of Transcription (expression) of trkB in piriform cortex associated with convulsion
2) Confidence 0.44 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.03 Pain Relevance 0.45
In CA3 and CA1 pyramidal cell layers, chronic ECS significantly elevated the acute induction of BDNF, and tended to prolong the expression of BDNF and trkB mRNA.
Positive_regulation (prolong) of Transcription (expression) of trkB in pyramidal cell associated with convulsion and pyramidal cell
3) Confidence 0.44 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.98 Pain Relevance 0.36
BDNF has been reported to activate transcription factors, such as CREB and NF?
Positive_regulation (as) of Transcription (transcription) of factors
4) Confidence 0.22 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.25 Pain Relevance 0.03
On the other hand, antidepressants increased the transcription of factors that became down regulated upon PMA-treatment.
Positive_regulation (increased) of Transcription (transcription) of factors associated with antidepressant
5) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.08 Pain Relevance 0.43

General Comments

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