INT47688

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.79
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
dentate gyrus granule cell layer 2
hippocampus 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 14 100.00 Very High Very High Very High
bDMF 10 100.00 Very High Very High Very High
Pyramidal cell 2 82.80 Quite High
antidepressant 5 81.96 Quite High
antagonist 4 70.68 Quite High
Glutamate receptor 2 70.20 Quite High
gABA 36 60.48 Quite High
Desipramine 1 46.00 Quite Low
Morphine 1 29.52 Quite Low
cocaine 1 28.72 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 43 99.98 Very High Very High Very High
Epilepsy 22 91.16 High High
Malformations Of Cortical Development 1 90.16 High High
Urological Neuroanatomy 2 88.88 High High
Cognitive Disorder 1 45.60 Quite Low
Injury 2 43.96 Quite Low
Stress 4 25.00 Low Low
Status Epilepticus 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the dentate gyrus granule cell layer, chronic ECS decreased the acute induction of BDNF and trkB mRNA by approximately 50%, but prolonged their expression: levels remained elevated two- to threefold 18 hr later after the last chronic ECS treatment, but returned to control 18 hr after acute ECS.
Negative_regulation (decreased) of Positive_regulation (induction) of trkB in dentate gyrus granule cell layer associated with convulsion
1) Confidence 0.41 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.04 Pain Relevance 0.19
Hippocampal kindling of adult mice decreased KCC2 expression in the hippocampus, through activation of the BDNF / trkB pathway [262].
Negative_regulation (decreased) of Positive_regulation (activation) of trkB in hippocampus associated with hippocampus and bdmf
2) Confidence 0.21 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.75 Pain Relevance 0.28

General Comments

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