INT47689

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 44
Total Number 47
Disease Relevance 16.84
Pain Relevance 19.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
hippocampus 5
neurons 5
spinal cord 4
brain 2
nerve 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 48 100.00 Very High Very High Very High
allodynia 11 100.00 Very High Very High Very High
fluoxetine 268 99.98 Very High Very High Very High
Hyperalgesia 51 99.84 Very High Very High Very High
Freund adjuvant 40 99.84 Very High Very High Very High
Hippocampus 234 99.80 Very High Very High Very High
antidepressant 157 99.78 Very High Very High Very High
Spinal cord 144 99.78 Very High Very High Very High
opioid receptor 1 99.76 Very High Very High Very High
spinothalamic tract 12 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 42 100.00 Very High Very High Very High
Tooth Injuries 4 100.00 Very High Very High Very High
Hyperalgesia 79 99.84 Very High Very High Very High
Nervous System Injury 26 99.72 Very High Very High Very High
Pain 94 99.58 Very High Very High Very High
Convulsion 60 99.58 Very High Very High Very High
Injury 83 99.50 Very High Very High Very High
Hypoxia 18 99.36 Very High Very High Very High
Spinal Cord Injury 133 99.18 Very High Very High Very High
Ganglion Cysts 29 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
Positive_regulation (activates) of TrkB in spinal cord associated with pain and spinal cord
1) Confidence 0.68 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.32 Pain Relevance 0.37
These results indicate that activation of TrkB signal pathway prevents LFS from inducing synaptic depression in visual cortex in vivo.
Positive_regulation (activation) of TrkB in cortex associated with li-fraumeni syndrome and depression
2) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736347 Disease Relevance 0.86 Pain Relevance 0.42
To test this hypothesis we have investigated if increases in BDNF and trkB mRNAs are associated with changes in the synaptic release of glutamate in the dorsal hippocampus in the conscious rat by combining the technique of in vivo microdialysis with in situ hybridization histochemistry.
Spec (investigated) Positive_regulation (increases) of trkB in hippocampus associated with glutamate and hippocampus
3) Confidence 0.66 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.46
Levels of BDNF and trkB mRNAs were increased in the hippocampus in a dose-dependent fashion following the stimulations.
Positive_regulation (increased) of trkB in hippocampus associated with hippocampus
4) Confidence 0.66 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.71
Chronic (21 d), but not acute (1 d), administration of several different antidepressant drugs, including tranylcypromine, sertraline, desipramine, or mianserin, significantly increased BDNF mRNA and all but mianserin increased trkB mRNA in hippocampus.
Positive_regulation (increased) of trkB in hippocampus associated with desipramine, antidepressant and hippocampus
5) Confidence 0.66 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.92 Pain Relevance 0.50
In the dentate gyrus granule cell layer, chronic ECS decreased the acute induction of BDNF and trkB mRNA by approximately 50%, but prolonged their expression: levels remained elevated two- to threefold 18 hr later after the last chronic ECS treatment, but returned to control 18 hr after acute ECS.
Positive_regulation (induction) of trkB in dentate gyrus granule cell layer associated with convulsion
6) Confidence 0.66 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.03 Pain Relevance 0.19
The purpose of this study was to characterize the impact of tooth injury on the distribution of tyrosine receptor kinase B (TrkB) among trigeminal ganglion neurons and assess the time course for tooth injury-induced TrkB distribution changes.
Positive_regulation (injury-induced) of TrkB in trigeminal ganglion associated with ganglion cysts, tooth injuries and trigeminal ganglion neurons
7) Confidence 0.50 Published 2003 Journal J Endod Section Abstract Doc Link 12597715 Disease Relevance 0.64 Pain Relevance 0.16
Using tract tracing coupled to immunofluorescent labeling for TrkB, we observed that in all levels of the spinal cord most STT neurons were immunoreactive for TrkB.
Positive_regulation (immunoreactive) of TrkB in spinal cord associated with spinothalamic tract and spinal cord
8) Confidence 0.49 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.26 Pain Relevance 0.79
Early exercise in spinal cord injured rats induces allodynia through TrkB signaling.
Positive_regulation (induces) of TrkB in spinal cord associated with allodynia and spinal cord
9) Confidence 0.48 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 19222991 Disease Relevance 0.77 Pain Relevance 0.88
This study showed that both early motor balance and coordination training on the Rota-rod, and simple treadmill training for 2 weeks, increased synaptophysin immunoreactivity, but not that of BDNF or TrkB, in subcortical regions such as the hippocampus, dentate gyrus, and thalamus of the ischemic hemisphere in an MCAO rat model.
Neg (not) Positive_regulation (increased) of TrkB in hippocampus associated with middle cerebral artery infarction, thalamus and hippocampus
10) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.10 Pain Relevance 0.29
However, tramadol when administered repeatedly did not increase the levels of mRNA encoding for brain-derived neurotrophic factor (BDNF) and its receptor, TrkB.
Neg (not) Positive_regulation (increase) of TrkB in brain associated with tramadol
11) Confidence 0.45 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464068 Disease Relevance 0.08 Pain Relevance 0.97
Our results show that, in rat hypothalamic cultures, brain-derived neurotrophic factor, and NT-3 have a potent stimulatory effect on peptide synthesis in somatostatinergic neurons, likely through direct activation of TrkB and TrkC receptors.
Positive_regulation (activation) of TrkB in neurons
12) Confidence 0.40 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.54
Upon tissue injury or noxious stimulation, SP and BDNF are released into laminae I and II of the spinal cord dorsal horn, where through activation of their respective postsynaptic receptors, neurokinin-1 (NK-1) and tyrosine kinase B (trkB), contribute to development of hyperalgesia and central sensitization associated with chronic pain [15-18].
Positive_regulation (activation) of trkB in spinal cord dorsal horn associated with hyperalgesia, central sensitization, lasting pain, injury, dorsal horn, spinal cord and substance p
13) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.89 Pain Relevance 1.24
Upon tissue injury or noxious stimulation, SP and BDNF are released into laminae I and II of the spinal cord dorsal horn, where through activation of their respective postsynaptic receptors, neurokinin-1 (NK-1) and tyrosine kinase B (trkB), contribute to development of hyperalgesia and central sensitization associated with chronic pain [15-18].
Positive_regulation (activation) of tyrosine kinase B in spinal cord dorsal horn associated with hyperalgesia, central sensitization, lasting pain, injury, dorsal horn, spinal cord and substance p
14) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.89 Pain Relevance 1.24
Many of the NMDA protective actions are attributed to BDNF secretion, which then activates TrkB receptors on this neuron itself or on surrounding neurons to elicit survival responses.
Positive_regulation (activates) of TrkB in neurons
15) Confidence 0.34 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
Increases in NK-1 receptor and BDNF gene expression in the dorsal horn likely represent a secondary effect resulting from facilitated activation of NMDA, NK-1 and trkB receptors located on the secondary afferents.
Positive_regulation (activation) of trkB in dorsal horn associated with dorsal horn
16) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.46 Pain Relevance 0.75
Hippocampal kindling of adult mice decreased KCC2 expression in the hippocampus, through activation of the BDNF / trkB pathway [262].
Positive_regulation (activation) of trkB in hippocampus associated with hippocampus and bdmf
17) Confidence 0.25 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.73 Pain Relevance 0.27
Sections were stained for Ki-67, BDNF and TrkB mRNA by in situ hybridisation, and immunofluorescent for pCREB and Wnt3a proteins.


Positive_regulation (stained) of TrkB
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.45
This is in agreement to that reported for TrkB receptor activation in cortical and granule neurons, which is primarily coupled to PLC?
Positive_regulation (reported) of TrkB in neurons
19) Confidence 0.25 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.16 Pain Relevance 0
Indeed, the intracellular signals activated by NMDA, such as ERK and Akt, are partially dependent on TrkB activation, as also observed for GSK3 signalling in the present study [30].
Positive_regulation (activation) of TrkB
20) Confidence 0.25 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04

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