INT4769

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Context Info
Confidence 0.44
First Reported 1984
Last Reported 2004
Negated 2
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 2.05
Pain Relevance 15.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
brain 2
neurons 2
spinal cord 1
muscle 1
pallidum 1
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 52 100.00 Very High Very High Very High
Morphine 37 100.00 Very High Very High Very High
agonist 29 100.00 Very High Very High Very High
narcan 16 100.00 Very High Very High Very High
Analgesic 11 100.00 Very High Very High Very High
MU agonist 7 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Enkephalin 52 99.80 Very High Very High Very High
tolerance 18 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 9 99.52 Very High Very High Very High
Neuroblastoma 3 99.44 Very High Very High Very High
Pain 2 97.80 Very High Very High Very High
Hypoglycemia 4 95.32 Very High Very High Very High
Urological Neuroanatomy 9 94.60 High High
INFLAMMATION 1 93.36 High High
Repression 2 90.60 High High
Glioma 2 89.76 High High
Inflammatory Pain 1 79.96 Quite High
Targeted Disruption 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the delta 1-opioid receptor antagonist 7-benzylidenenaltrexon per se did not influence [3H]-acetylcholine release, but prevented of the inhibition of release by D-Pen2-D-Pen5-enkephalin.
Neg (not) Regulation (influence) of delta 1-opioid associated with antagonist, enkephalin and opioid receptor
1) Confidence 0.44 Published 1998 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 10198826 Disease Relevance 0 Pain Relevance 0.92
The D-amino acid and the anionic residues, either Glu or Asp, as well as their unique amino acid compositions are responsible for the remarkable biostability, high delta-receptor affinity, bioactivity and peptide conformation.
Regulation (responsible) of delta-receptor
2) Confidence 0.38 Published 1999 Journal Prog. Neurobiol. Section Abstract Doc Link 10080383 Disease Relevance 0 Pain Relevance 0.17
Oligomerization of the human delta-opioid receptor and its regulation by ligand occupancy were explored following expression in HEK293 cells using each of co-immunoprecipitation of differentially epitope-tagged forms of the receptor, bioluminescence resonance energy transfer and time-resolved fluorescence resonance energy transfer.
Regulation (regulation) of delta-opioid receptor associated with opioid receptor
3) Confidence 0.27 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278447 Disease Relevance 0 Pain Relevance 0.21
Isometric recordings of mechanical activity in muscle strips from rat and human detrusor were performed and the effect of mu- and delta-opioid receptor stimulation and blockade on detrusor contraction induced by electrical field stimulation was tested.
Regulation (effect) of delta-opioid receptor in muscle associated with overactive bladder and opioid receptor
4) Confidence 0.24 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1279654 Disease Relevance 0.33 Pain Relevance 0.51
Effect of delta-opioid receptor agonist deltorphin on circulating concentrations of luteinizing hormone and follicle stimulating hormone in healthy fertile women.
Regulation (Effect) of delta-opioid receptor in follicle associated with narcan, agonist and opioid receptor
5) Confidence 0.21 Published 1998 Journal Hum. Reprod. Section Title Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.51
To determine the role of delta-opioid receptors in the modulation of hypothalamic-pituitary-adrenal activity, we studied in normal subjects the effect of the highly selective delta-opioid receptor agonist deltorphin (DT) on the secretion of ACTH, cortisol, and arginine vasopressin in response to insulin-induced hypoglycemia.
Regulation (effect) of delta-opioid receptor in pituitary associated with hypoglycemia, agonist, opioid receptor and delta opioid receptors
6) Confidence 0.20 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322422 Disease Relevance 0.30 Pain Relevance 0.27
Although MOR-1-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were observed only in the superficial laminae, MOR-1C-LI was abundant in the superficial laminae of the dorsal horn and around the central canal.
Regulation (immunoreactivity) of delta opioid receptor-like in central canal associated with dorsal horn and opioid receptor
7) Confidence 0.14 Published 2000 Journal Neuroreport Section Abstract Doc Link 10884050 Disease Relevance 0 Pain Relevance 0.40
To address this issue, the authors investigated the effects of mu- and delta-receptor agonists on excitatory postsynaptic currents (EPSCs) and on membrane properties of neocortical neurons.
Spec (investigated) Regulation (effects) of delta-receptor in neurons associated with agonist
8) Confidence 0.13 Published 2000 Journal Anesthesiology Section Abstract Doc Link 11020761 Disease Relevance 0 Pain Relevance 0.32
In this report, we demonstrated that interleukin-6 strongly induces mu-opioid receptor mRNA in the human neuroblastoma cell line SH SY5Y, whereas delta-opioid receptor mRNA levels are not influenced.
Neg (not) Regulation (influenced) of delta-opioid receptor mRNA associated with neuroblastoma and opioid receptor
9) Confidence 0.10 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.27 Pain Relevance 0.60
The delta opioid receptor is an important target for analgesic drug development.
Regulation (target) of delta opioid receptor associated with analgesic and opioid receptor
10) Confidence 0.07 Published 1994 Journal Life Sci. Section Abstract Doc Link 8201839 Disease Relevance 0 Pain Relevance 0.23
Extracellular recordings were made from 161 warm-sensitive, six cold-sensitive and 153 temperature-insensitive neurons in slices of the preoptic area/anterior hypothalamus (PO/AH) of rats, to investigate the effects of the kappa-receptor opioid agonist dynorphin A1-17 and the delta-receptor opioid agonist DPDPE on neuronal response characteristics.
Spec (investigate) Regulation (effects) of delta-receptor in neurons associated with mu agonist and dynorphin
11) Confidence 0.06 Published 1998 Journal Brain Res. Section Abstract Doc Link 9554984 Disease Relevance 0 Pain Relevance 0.39
The regulation of delta-opioid receptor mRNA levels by db-cAMP was not sensitive to the protein synthesis inhibitor cycloheximide, suggesting that de novo protein synthesis is not required in this process.
Regulation (regulation) of delta-opioid receptor mRNA associated with opioid receptor
12) Confidence 0.05 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9003047 Disease Relevance 0.21 Pain Relevance 0.33
Regulation of delta-opioid receptor mRNA levels by receptor-mediated and direct activation of the adenylyl cyclase-protein kinase A pathway.
Regulation (Regulation) of delta-opioid receptor mRNA associated with analgesic and opioid receptor
13) Confidence 0.04 Published 1997 Journal J. Neurochem. Section Title Doc Link 9003047 Disease Relevance 0.24 Pain Relevance 0.35
We have demonstrated that three delta-receptor agonists [D-Ala2, D-Leu5]enkephalin (DADLE), [D-Pen2, D-Pen5]enkephalin (DPDPE) and [D-Thr2, Leu5, Thr6] enkephalin (DTLET) appear to mediate their effects via the delta-receptor since they are readily reversed by the selective delta-receptor antagonist ICI 174864.
Regulation (effects) of delta-receptor associated with antagonist, agonist and enkephalin
14) Confidence 0.01 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3001576 Disease Relevance 0 Pain Relevance 0.52
The results of several studies suggest that pharmacological blockade of these receptors results in decreases in ethanol drinking behavior, but an approximately equal number of reports have failed to observe an effect of delta-receptor antagonism on ethanol drinking.
Regulation (effect) of delta-receptor
15) Confidence 0.01 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 11584142 Disease Relevance 0.07 Pain Relevance 0.17
The enkephalins not only act on the classic morphine (mu-) receptor but also on the delta-receptor, which often co-exists with mu-receptors and mediates pain relief.
Regulation (act) of delta-receptor associated with pain, enkephalin and morphine
16) Confidence 0.01 Published 2000 Journal Ups. J. Med. Sci. Section Abstract Doc Link 10893049 Disease Relevance 0.16 Pain Relevance 1.40
Differential effects of mu- and delta-receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices.
Regulation (effects) of delta-receptor in brain associated with mu agonist, gabaergic and enkephalin
17) Confidence 0.01 Published 1991 Journal Synapse Section Title Doc Link 1656539 Disease Relevance 0 Pain Relevance 1.02
This is also the first report to demonstrate that gonadal hormones regulate delta receptor densities in brain regions other than the HYP of OVX females.
Regulation (regulate) of delta receptor in gonadal
18) Confidence 0.00 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 11179845 Disease Relevance 0.47 Pain Relevance 0.80
These results suggest that brain and spinal cord receptors mediating the effects of DAGO differ in terms of the development of cross-tolerance to morphine; and suggest that tolerance to systemic morphine may be due to changes in spinal delta and brain mu and delta receptor mechanisms.
Regulation (changes) of delta receptor in spinal cord associated with tolerance, enkephalin, morphine and spinal cord
19) Confidence 0.00 Published 1990 Journal Life Sci. Section Abstract Doc Link 2154656 Disease Relevance 0 Pain Relevance 2.17
To determine whether such opioid stimulatory effects may be mediated directly in the pallidum, in vivo microdialysis was used to study the effects of local administration of several concentrations of the mu receptor agonists morphine and morphine-6-glucuronide (M6G) as well as the the delta receptor agonist SNC80 on pallidal enkephalin release in freely moving rats.
Regulation (effects) of delta receptor in pallidum associated with agonist, enkephalin, opioid and morphine
20) Confidence 0.00 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618438 Disease Relevance 0 Pain Relevance 1.29

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