INT47690

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 9
Speculated 14
Reported most in Abstract
Documents 118
Total Number 135
Disease Relevance 53.02
Pain Relevance 64.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 14
spinal cord 10
neurons 8
hippocampus 6
dorsal root ganglia 5
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 1820 100.00 Very High Very High Very High
fluoxetine 448 100.00 Very High Very High Very High
Pain 405 100.00 Very High Very High Very High
sSRI 169 100.00 Very High Very High Very High
Nerve growth factor 119 100.00 Very High Very High Very High
Serotonin 98 100.00 Very High Very High Very High
dorsal root ganglion 73 100.00 Very High Very High Very High
monoamine 68 100.00 Very High Very High Very High
Neuropeptide 63 100.00 Very High Very High Very High
Dopamine 52 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1046 100.00 Very High Very High Very High
Stress 789 100.00 Very High Very High Very High
Pain 531 100.00 Very High Very High Very High
INFLAMMATION 189 100.00 Very High Very High Very High
Ganglion Cysts 132 100.00 Very High Very High Very High
Headache 14 100.00 Very High Very High Very High
Cluster Headache 5 100.00 Very High Very High Very High
Nociception 317 99.98 Very High Very High Very High
Nervous System Injury 111 99.88 Very High Very High Very High
Death 135 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies examining whether stress affects other epigenetic pathways involved in regulation of the BDNF gene, such as DNA methylation, may provide additional valuable information regarding the pathophysiology of stress-related mental disorders.


Regulation (regulation) of BDNF associated with mental disorders and stress
1) Confidence 0.62 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.98 Pain Relevance 0
In addition, we examined the influence of transcriptional changes on BDNF protein levels.
Spec (examined) Regulation (influence) of BDNF
2) Confidence 0.62 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.72 Pain Relevance 0.11
After a single injection the down-regulation was detected at 4 h (TCP, fluoxetine, paroxetine and sertraline) but BDNF mRNA levels were not altered at 24 h post drug (TCP, fluoxetine and paroxetine).
Neg (not) Regulation (altered) of BDNF associated with bdmf and fluoxetine
3) Confidence 0.62 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 1.26
Administration of inhibitors of noradrenaline re-uptake (desipramine and maprotiline) or the atypical antidepressant mianserin had no effect on BDNF mRNA levels at either single (4 h post drug, desipramine) or repeated (24 h post drug, desipramine, maprotiline, mianserin) treatment.
Neg (no) Regulation (effect) of BDNF associated with antidepressant, desipramine, noradrenaline and bdmf
4) Confidence 0.62 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 1.31
The aim of the present study was to test the hypothesis that the previously shown biphasic action by the antidepressant drugs on total BDNF expression is explained by differential BDNF transcript regulation.
Regulation (regulation) of BDNF associated with antidepressant
5) Confidence 0.61 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.08 Pain Relevance 0.34
In summary, this study shows clear evidence of differential BDNF transcript regulation following acute and chronic antidepressant drug treatment.
Regulation (regulation) of BDNF associated with antidepressant
6) Confidence 0.61 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.18 Pain Relevance 0.31
The results indicate that distinct antidepressants differentially regulate BDNF mRNAs through a region-specific recruitment of the four BDNF promoters and suggest that diverse signaling mechanisms may be recruited to regulate BDNF transcripts.
Regulation (regulate) of BDNF associated with antidepressant and bdmf
7) Confidence 0.59 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907316 Disease Relevance 0.26 Pain Relevance 0.80
Post-transcriptional control of BDNF mRNA in the brain likely plays a role in the production of BDNF protein [29].
Regulation (control) of BDNF in brain
8) Confidence 0.59 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.07 Pain Relevance 0.04
Previous studies have shown that intracellular transcriptional regulation of NK-1 receptor and BDNF genes, during either spinal nociceptive processing or stress-related stimulation of hippocampus, may be modulated by transduction pathways involving activation of extracellular signal-regulated kinases (ERK)/cAMP response element binding protein (CREB) cascades [25-29].
Regulation (regulation) of BDNF in spinal associated with stress, nociception and hippocampus
9) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.53 Pain Relevance 0.75
It was speculated that agents acting on both noradrenergic and serotonergic transporters might have a greater influence on BDNF levels.
Regulation (influence) of BDNF
10) Confidence 0.53 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19110026 Disease Relevance 0.09 Pain Relevance 0.30
The aim of our study was to determine effects of venlafaxine vs. fluoxetine on serum BDNF levels in depressive patients.
Spec (determine) Regulation (effects) of BDNF associated with depression and fluoxetine
11) Confidence 0.53 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19110026 Disease Relevance 0.19 Pain Relevance 0.30
Preclinical and clinical studies have suggested dysregulation in BDNF occurs under conditions of chronic stress and depression.
Regulation (dysregulation) of BDNF associated with stress and depression
12) Confidence 0.52 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.02 Pain Relevance 0.52
Although BDNF mRNA in cortical dendrites will not reach the striatum, changes in cortical BDNF levels could affect survival of striatal cells.
Regulation (changes) of BDNF in striatum
13) Confidence 0.52 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.59 Pain Relevance 0
The present study investigated the effects of acute and chronic administration of the selective serotonin reuptake inhibitor, fluoxetine (10mg/kg p.o.), upon regional rat brain levels of BDNF mRNA and protein expression.
Spec (investigated) Regulation (effects) of BDNF in brain associated with ssri and fluoxetine
14) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.51
Despite the methodological difference, the SIS-specific regulation of distinct BDNF transcripts demonstrated by Nair et al. is consistent with that in our study.
Regulation (regulation) of BDNF associated with stress
15) Confidence 0.45 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.86 Pain Relevance 0.19
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.
Regulation (Regulation) of BDNF in brain associated with antidepressant and convulsion
16) Confidence 0.45 Published 1995 Journal J. Neurosci. Section Title Doc Link 7472505 Disease Relevance 0.95 Pain Relevance 0.17
Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine.
Regulation (role) of BDNF gene associated with migraine
17) Confidence 0.45 Published 2008 Journal J Neural Transm Section Abstract Doc Link 18478177 Disease Relevance 0.44 Pain Relevance 0.34
There was no significant alteration for BDNF-IR in the thoracic segments after surgical incision as compared with the sham-operation (Figure 1F and 1G) (Table 1) suggesting that the incision induced segmental BDNF upregulation in the spinal cord.


Neg (no) Regulation (alteration) of BDNF-IR in spinal cord associated with bdmf and spinal cord
18) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.90
The authors examined the roles of BDNF and excitatory Gs-protein in this change.
Spec (examined) Regulation (roles) of BDNF and excitatory Gs-protein
19) Confidence 0.45 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20613480 Disease Relevance 0.16 Pain Relevance 0.36
Second, they demonstrate that one of the main effects of BDNF action during memory formation is to increase the expression of GluR1 in synaptic membranes, and that it does so by activating the translation machinery through the engagement of mTOR and its downstream target p70S6K.
Regulation (effects) of BDNF
20) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.06 Pain Relevance 0.12

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