INT47691

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 13.64
Pain Relevance 6.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
myocardium 2
pyramidal cell 2
brain 2
amygdala 2
nucleus accumbens 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
qutenza 2 100.00 Very High Very High Very High
Thermal hyperalgesia 2 99.96 Very High Very High Very High
Nerve growth factor 5 99.92 Very High Very High Very High
amygdala 12 99.68 Very High Very High Very High
Pain 25 99.42 Very High Very High Very High
nociceptor 10 99.42 Very High Very High Very High
Dopamine 1 99.04 Very High Very High Very High
ischemia 16 98.72 Very High Very High Very High
Pyramidal cell 2 98.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroleptic Malignant Syndrome 36 100.00 Very High Very High Very High
Parkinson's Disease 3 99.96 Very High Very High Very High
Hyperalgesia 2 99.96 Very High Very High Very High
Pain 17 99.24 Very High Very High Very High
Convulsion 26 99.02 Very High Very High Very High
Ventricular Remodeling 40 98.96 Very High Very High Very High
Myocardial Infarction 276 98.72 Very High Very High Very High
Cv Unclassified Under Development 12 98.72 Very High Very High Very High
Diabetes Mellitus 379 96.28 Very High Very High Very High
Injury 32 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that a diminished availability of full-length TrkB and an enhanced expression of truncated TrkB receptors in the injured cord could play an important role in reducing the effect of BDNF following injury.
Positive_regulation (enhanced) of Gene_expression (expression) of TrkB associated with injury
1) Confidence 0.62 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 17376001 Disease Relevance 0.40 Pain Relevance 0.32
After discontinuation of infusion, levels of TrkB recovered toward base line.
Positive_regulation (recovered) of Gene_expression (recovered) of TrkB
2) Confidence 0.50 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.15 Pain Relevance 0.31
The current results also show that an acute injection of cocaine results in a decrease in the number of tyrosine kinase B and C receptors immunoreactive neuronal profiles in specific regions of the nucleus accumbens and neostriatum, indicating that cocaine-induced increases in extracellular dopamine in the striatal complex result in compensatory decreases in the expression of tyrosine kinase B and C receptors.
Positive_regulation (decreases) of Gene_expression (expression) of tyrosine kinase B in nucleus accumbens associated with nucleus accumbens, dopamine and cocaine
3) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605901 Disease Relevance 0 Pain Relevance 0.73
Neonatal maternal separation increases brain-derived neurotrophic factor and tyrosine kinase receptor B expression in the descending pain modulatory system.
Positive_regulation (increases) of Gene_expression (expression) of tyrosine kinase receptor B in brain associated with pain and nociceptor
4) Confidence 0.49 Published 2009 Journal Neurosignals Section Title Doc Link 19546592 Disease Relevance 1.03 Pain Relevance 0.79
The results revealed an increase in the expression of BDNF and TrkB in the amygdala after NMS.
Positive_regulation (increase) of Gene_expression (expression) of TrkB in amygdala associated with neuroleptic malignant syndrome and amygdala
5) Confidence 0.49 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.07 Pain Relevance 0.66
Expression of BDNF and TrkB following NMS and CRD stimulation was determined using immunohistochemistry.
Positive_regulation (stimulation) of Spec (determined) Gene_expression (Expression) of TrkB associated with neuroleptic malignant syndrome
6) Confidence 0.49 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.08 Pain Relevance 0.65
Expression of BDNF and TrkB following NMS and CRD stimulation was determined using immunohistochemistry.
Positive_regulation (following) of Spec (determined) Gene_expression (Expression) of TrkB associated with neuroleptic malignant syndrome
7) Confidence 0.49 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.08 Pain Relevance 0.65
TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons.
Positive_regulation (activation) of Gene_expression (expression) of TrkB in neurons associated with qutenza and spinothalamic tract neurons
8) Confidence 0.49 Published 2005 Journal J. Comp. Neurol. Section Title Doc Link 15977164 Disease Relevance 0.31 Pain Relevance 0.55
A similar effect was observed in layer 2 of the piriform cortex, where chronic ECS significantly increased the acute induction and prolonged the expression of BDNF and trkB mRNA.
Positive_regulation (prolonged) of Gene_expression (expression) of trkB in piriform cortex associated with convulsion
9) Confidence 0.48 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.03 Pain Relevance 0.45
In CA3 and CA1 pyramidal cell layers, chronic ECS significantly elevated the acute induction of BDNF, and tended to prolong the expression of BDNF and trkB mRNA.
Positive_regulation (prolong) of Gene_expression (expression) of trkB in pyramidal cell associated with convulsion and pyramidal cell
10) Confidence 0.48 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.98 Pain Relevance 0.36
It is possible that a diminished availability of full-length TrkB and an enhanced expression of truncated TrkB receptors in the injured cord could play an important role in reducing the effect of BDNF following injury.
Positive_regulation (enhanced) of Gene_expression (expression) of TrkB associated with injury
11) Confidence 0.45 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 17376001 Disease Relevance 0.40 Pain Relevance 0.33
Like NGF, agonists of tyrosine kinaseB (trkB) receptors (NT-4/5 and BDN F) induced thermal hyperalgesia in the first 5 h after treatment (NT-4/5 > BDNF) but the effect had worn off by 24 h.
Positive_regulation (induced) of Gene_expression (agonists) of trkB associated with thermal hyperalgesia and agonist
12) Confidence 0.40 Published 1999 Journal Pain Section Abstract Doc Link 10342408 Disease Relevance 0.26 Pain Relevance 0.67
Any potent antiulcer drug should stimulate mucosal proliferation, regeneration and polyamine synthesis, afford protection by attenuating the mitochondrial dysfunction, increasing the production of growth factors, healing of acute lesions and inhibition of gastric acid secretion.[4] Therefore, the link between cell proliferation, polyamines, growth factors and drug treatment may offer a new insight in ulcer therapy.
Positive_regulation (increasing) of Gene_expression (production) of factors associated with parkinson's disease and ulcers
13) Confidence 0.01 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2950387 Disease Relevance 0.95 Pain Relevance 0.03
Insulin induces increased expression of translation initiation factors and phosphorylation of 4EBP-1 and S6K, critical cell cycle regulators downstream of mTOR.
Positive_regulation (increased) of Gene_expression (expression) of factors
14) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.65 Pain Relevance 0.04
Although the effects of overexpressing angiogenic growth factors have been studied in inducing angiogenesis, the formation of functional vessels remains a challenge.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factors in vessels
15) Confidence 0.01 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797944 Disease Relevance 0.75 Pain Relevance 0.05
The coadministration of Ad.VEGF and Ad.Ang1 in the nondiabetic (CVAMI) group markedly induced expression of both growth factors.
Positive_regulation (induced) of Gene_expression (expression) of factors
16) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.77 Pain Relevance 0.10
There have been several attempts at preclinical and clinical levels to induce angiogenesis by overexpressing angiogenic factors in the peri-infarct zone after myocardial infarction (MI).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of factors associated with myocardial infarction
17) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.28 Pain Relevance 0.15
Therefore, supporting the overexpression of these factors by means of gene therapy might aid in repairing the process of impaired angiogenesis in the diabetic ischemic myocardium.
Positive_regulation (overexpression) of Gene_expression (overexpression) of factors in myocardium associated with diabetes mellitus
18) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.29 Pain Relevance 0.05
Nevertheless, Sheu and colleagues have reported that the sustained pattern of ERK-P up-regulation in the distal stump was correlated with three sequential peaks of increased expression of growth factors: NGF, GDNF and BDNF, in chronological order [4].
Positive_regulation (increased) of Gene_expression (expression) of factors associated with nerve growth factor
19) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.14 Pain Relevance 0.08

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