INT47692

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 9.64
Pain Relevance 13.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 8
hippocampus 4
dentate gyrus 2
spinal cord 2
spinal 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 554 100.00 Very High Very High Very High
Spinal cord 176 100.00 Very High Very High Very High
fluoxetine 133 100.00 Very High Very High Very High
Hippocampus 82 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
neurotrophin 3 8 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
tolerance 4 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
cocaine 4 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 196 100.00 Very High Very High Very High
Anxiety Disorder 78 100.00 Very High Very High Very High
Convulsion 55 99.98 Very High Very High Very High
Hypersensitivity 90 99.68 Very High Very High Very High
Apoptosis 3 99.56 Very High Very High Very High
Pain 247 99.00 Very High Very High Very High
INFLAMMATION 43 98.50 Very High Very High Very High
Neuropathic Pain 188 95.40 Very High Very High Very High
Ganglion Cysts 10 93.84 High High
Recurrence 1 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the dentate gyrus granule cell layer, chronic ECS decreased the acute induction of BDNF and trkB mRNA by approximately 50%, but prolonged their expression: levels remained elevated two- to threefold 18 hr later after the last chronic ECS treatment, but returned to control 18 hr after acute ECS.
Negative_regulation (decreased) of Positive_regulation (induction) of BDNF in dentate gyrus granule cell layer associated with convulsion
1) Confidence 0.59 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.04 Pain Relevance 0.19
Intraplantar injection of antibody to NGF together with Freund's adjuvant prevented the increase in BDNF mRNA.
Negative_regulation (prevented) of Positive_regulation (increase) of BDNF mRNA associated with nerve growth factor
2) Confidence 0.59 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.80 Pain Relevance 0.73
Thus, blocking the upregulated spinal BDNF may be a novel potential therapeutic approach to treat post-operative pain.
Negative_regulation (blocking) of Positive_regulation (upregulated) of BDNF in spinal associated with pain and bdmf
3) Confidence 0.51 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.78 Pain Relevance 1.30
However, unlike the activated inflammatory mediators which were not affected by the sciatic nerve block [23,24], the increased BDNF in the DRG or spinal cord could be totally prevented by the sciatic nerve block.
Negative_regulation (prevented) of Positive_regulation (increased) of BDNF in sciatic nerve associated with inflammatory mediators, sciatic nerve, bdmf and spinal cord
4) Confidence 0.51 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.61 Pain Relevance 1.45
The fact that pretreatment of lidocaine completely prevented the upregulation of BDNF after incision indicated that the increased BDNF is through by nerve afferent transmission.
Negative_regulation (prevented) of Positive_regulation (upregulation) of BDNF in nerve associated with bdmf and lidocaine
5) Confidence 0.51 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.17 Pain Relevance 1.05
Our data suggest that chronic treatment with the novel antidepressant duloxetine not only produces a marked upregulation of BDNF mRNA and protein, but may also affect the subcellular redistribution of the neurotrophin.
Negative_regulation (produces) of Positive_regulation (upregulation) of BDNF mRNA associated with antidepressant and duloxetine
6) Confidence 0.43 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17327885 Disease Relevance 0.15 Pain Relevance 0.64
Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus.
Negative_regulation (reduction) of Positive_regulation (enhancement) of BDNF in brain associated with stress, anxiety disorder and hippocampus
7) Confidence 0.43 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.74 Pain Relevance 0.05
Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus.
Negative_regulation (reduction) of Positive_regulation (enhancement) of BDNF in brain associated with stress, anxiety disorder and hippocampus
8) Confidence 0.43 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.74 Pain Relevance 0.05
Chronic social defeat stress has been shown to downregulate the mRNA levels of BDNF transcripts IV and VI in the mouse hippocampus, which is accompanied by significant increases in H3-K27 dimethylation at the promoter of exons IV and VI without changes in H3 acetylation status at the promoter of either exons IV or VI.7 This result taken together with our findings suggests that chromatin remodeling through histone modification could play an important role in stress-induced gene expression in vivo.
Negative_regulation (downregulate) of Positive_regulation (dimethylation) of BDNF in hippocampus associated with stress and hippocampus
9) Confidence 0.43 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.87 Pain Relevance 0.27
Acute cocaine produced a transient increase in BDNF mRNA in the prefrontal cortex, associated with a long-lasting increase in drd3 mRNA, and a delayed and long-lasting increase in Drd3 protein in the nucleus accumbens.
Negative_regulation (produced) of Positive_regulation (increase) of BDNF mRNA in nucleus accumbens associated with nucleus accumbens and cocaine
10) Confidence 0.43 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671872 Disease Relevance 0.09 Pain Relevance 0.38
Apoptosis of beta cells can be prevented with intravitreal injections of BDNF+CNTF+forskolin or a caspase inhibitor.
Negative_regulation (prevented) of Positive_regulation (injections) of BDNF in beta cells associated with apoptosis
11) Confidence 0.41 Published 2002 Journal Prog Retin Eye Res Section Abstract Doc Link 12433376 Disease Relevance 0.92 Pain Relevance 0.08
First, hind-paw incision induced transient activation of BDNF expression, mainly localized in the nerve terminals and neurons in the lumbar DRG and spinal cord; Second, the increased BDNF expression was changed to large-sized neurons from the small-sized neurons in the DRG in response to surgical incision; Third, sciatic nerve block by local anesthetic can prevent the upregulated BDNF in the DRG and spinal cord; Finally, IT administration, but not IP administration of anti-BDNF antibody dramatically reduced the mechanical allodynia developed by the incision.
Negative_regulation (prevent) of Positive_regulation (upregulated) of BDNF in paw associated with allodynia, sciatic nerve, bdmf, local anesthetic and spinal cord
12) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.25 Pain Relevance 2.03
Similarly, depletion of intracellular calcium stores with thapsigargin and treatment with dantrolene, an inhibitor of calcium release from caffeine-ryanodine-sensitive stores, markedly inhibited activity-dependent BDNF release.
Negative_regulation (inhibited) of Positive_regulation (activity-dependent) of BDNF
13) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.08 Pain Relevance 0.25
Our results suggest that the reduction of brain-derived neurotrophic factor messenger RNA induced by monocular deprivation is related to the absence of pattern vision rather than to the competitive interactions that underlie the effects of monocular deprivation during the critical period.
Negative_regulation (reduction) of Positive_regulation (induced) of brain-derived neurotrophic factor in brain
14) Confidence 0.37 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848102 Disease Relevance 0 Pain Relevance 0.08
Despite the fact that BDNF mRNA was increased only after 14 days of fluoxetine treatment, blocking its action at a time when there was no discernible change in BDNF mRNA prevented not only the expected increase in progenitor mitosis, but also that in pCREB, presumably a more proximal regulator of neurogenesis.
Negative_regulation (blocking) of Positive_regulation (increased) of BDNF mRNA in proximal associated with neurodegenerative disease and fluoxetine
15) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.09 Pain Relevance 0.48
In summary: this experiment showed that icv K252a prevented the stimulating effect of fluoxetine on progenitor mitosis in the dentate gyrus, but did not prevent increased BDNF mRNA.
Negative_regulation (prevent) of Positive_regulation (increased) of BDNF mRNA in dentate gyrus associated with fluoxetine
16) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.97
Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation.
Negative_regulation (blocks) of Positive_regulation (upregulation) of brain-derived neurotrophic factor in brain associated with analgesic, tolerance and morphine
17) Confidence 0.36 Published 2009 Journal Neuroreport Section Title Doc Link 19033880 Disease Relevance 0 Pain Relevance 1.07
Intraperitoneal injection with infliximab reduces the BDNF induction in both DRG and spinal cord.


Negative_regulation (reduces) of Positive_regulation (induction) of BDNF in spinal cord associated with infliximab and spinal cord
18) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.63 Pain Relevance 1.13
Hippocampal kindling of adult mice decreased KCC2 expression in the hippocampus, through activation of the BDNF / trkB pathway [262].
Negative_regulation (decreased) of Positive_regulation (activation) of BDNF in hippocampus associated with hippocampus and bdmf
19) Confidence 0.19 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.70 Pain Relevance 0.28
BDNF or NT-3 induction of somatostatin release was inhibited by the Trk inhibitors K-252a and genistein, whereas K-252b, a less effective inhibitor, had no effect.
Negative_regulation (inhibited) of Positive_regulation (induction) of BDNF associated with neurotrophin 3 and somatostatin
20) Confidence 0.11 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11435757 Disease Relevance 0 Pain Relevance 0.68

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