INT47701

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 4.45
Pain Relevance 8.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
cortex 3
caudate putamen 2
striatum 2
D17 1
shell 1
Nr4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 46 99.98 Very High Very High Very High
Morphine 34 99.98 Very High Very High Very High
Nucleus accumbens 105 99.84 Very High Very High Very High
Enkephalin 67 99.80 Very High Very High Very High
medulla 13 99.42 Very High Very High Very High
qutenza 8 99.10 Very High Very High Very High
amygdala 174 98.64 Very High Very High Very High
Dopamine 10 98.08 Very High Very High Very High
agonist 4 97.92 Very High Very High Very High
adenocard 4 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 103 99.96 Very High Very High Very High
Sprains And Strains 8 94.92 High High
Apoptosis 25 94.44 High High
Hypertension 3 91.28 High High
Death 85 88.00 High High
Schizophrenia 2 78.64 Quite High
Parkinson's Disease 3 75.00 Quite High
Disease 6 74.96 Quite High
Aids-related Complex 70 66.48 Quite High
Infection 4 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, chronic treatment with clozapine reduces NGFI-B expression below basal levels in the rat forebrain, whereas haloperidol still induces high NGFI-B mRNA levels in the dorsolateral striatum.
Positive_regulation (induces) of NGFI-B mRNA in striatum
1) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.06 Pain Relevance 0.23
An acute treatment with clozapine or haloperidol induces high NGFI-B mRNA levels in the prefrontal and cingulate cortices and in the nucleus accumbens shell.
Positive_regulation (induces) of NGFI-B mRNA in shell associated with nucleus accumbens
2) Confidence 0.70 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.08 Pain Relevance 0.15
Administration of a high dose of caffeine (100 mg/kg) decreased locomotor behavior and increased NGFI-A and NGFI-B mRNA in the entire striatum.
Positive_regulation (increased) of NGFI-B in striatum
3) Confidence 0.69 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.14
The denervation process induced an increase of NGFI-B and enkephalin (ENK) mRNA levels and the increase of NGFI-B took place predominantly in ENK-containing cells.
Positive_regulation (increase) of NGFI-B associated with enkephalin
4) Confidence 0.69 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.51
The denervation process induced an increase of NGFI-B and enkephalin (ENK) mRNA levels and the increase of NGFI-B took place predominantly in ENK-containing cells.
Positive_regulation (increase) of NGFI-B associated with enkephalin
5) Confidence 0.69 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.54
NGFI-B and nor1 mRNAs are upregulated in brain reward pathways by drugs of abuse: different effects in Fischer and Lewis rats.
Positive_regulation (upregulated) of NGFI-B in brain
6) Confidence 0.68 Published 2000 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 10719211 Disease Relevance 0.09 Pain Relevance 0.42
After a single injection of cocaine, a similar upregulation of NGFI-B mRNA in striatal subregions and cortex cinguli was seen in both Fischer and Lewis rats.
Positive_regulation (upregulation) of NGFI-B mRNA in cortex associated with cocaine
7) Confidence 0.68 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719211 Disease Relevance 0.08 Pain Relevance 0.42
Morphine increased NGFI-B mRNA in medial caudate putamen and cortex cinguli in Lewis rats and Nor1 mRNA in medial caudate putamen in Fischer rats.
Positive_regulation (increased) of NGFI-B mRNA in caudate putamen associated with morphine
8) Confidence 0.68 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719211 Disease Relevance 0.08 Pain Relevance 0.53
Chronic cocaine upregulated NGFI-B mRNA in nucleus accumbens core, lateral caudate putamen and cingulate cortex in Fischer rats, whereas no effect was seen in Lewis rats.
Positive_regulation (upregulated) of NGFI-B mRNA in cingulate cortex associated with nucleus accumbens and cocaine
9) Confidence 0.68 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719211 Disease Relevance 0.07 Pain Relevance 0.66
Surprisingly, only NGFI-B and Nurr1 were induced in the glucocorticoid secreting regions of zonae reticularis and fasciculata of the cortex, starting 15 min after the stress.
Positive_regulation (induced) of NGFI-B in cortex associated with stress
10) Confidence 0.60 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.49 Pain Relevance 0.37
Striatal regions also exhibited ngfi-b induction in response to Ensure cues.
Positive_regulation (induction) of ngfi-b
11) Confidence 0.51 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.28
Further analysis revealed significant increases in ngfi-b in several prefrontal and primary sensory cortical areas.
Positive_regulation (increases) of ngfi-b in prefrontal
12) Confidence 0.51 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.05 Pain Relevance 0.34
The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).
Positive_regulation (caused) of NGFI-B associated with agonist
13) Confidence 0.50 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.38
The time course of the induction of NGFI-A, NGFI-B, fra-2 and TIS11 was similar to that previously observed with c-fos and the members of the jun family.
Positive_regulation (induction) of NGFI-B
14) Confidence 0.49 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.40 Pain Relevance 0.13
For example, the mRNAs for TNF-R1, FasL, and Nur77 are up-regulated between 2.8 and 7-fold [Mol.
Positive_regulation (up-regulated) of Nur77
15) Confidence 0.47 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12531535 Disease Relevance 0.17 Pain Relevance 0.08
Although zif268, ngfi-b and c-fos were increased in the diencephalon in the Ensure cues group, there was a paucity of thalamic and hypothalamic interregional gene-expression correlations (Figure 6C).
Positive_regulation (increased) of ngfi-b in diencephalon
16) Confidence 0.43 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.27
Ensure cues increased ngfi-b mRNA levels in telencephalic regions (see Additional file 3).
Positive_regulation (increased) of ngfi-b in telencephalic
17) Confidence 0.40 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.23 Pain Relevance 0.37
Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.
Positive_regulation (induction) of NGFI-B in nucleus associated with stress and qutenza
18) Confidence 0.35 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.42 Pain Relevance 0.14
Expression of zif268 was increased in all of the analyzed thalamic and hypothalamic regions in response to Ensure cues (Figure 5A,B), while ngfi-b was increased by Ensure cues in some thalamic regions but not in any of the hypothalamic regions analyzed (Figure 5C,D).
Positive_regulation (increased) of ngfi-b
19) Confidence 0.35 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.18
Rats at D19 of pregnancy also show a reduced ACTH response to forced swim stress (Johnstone et al., 2000) and mice on D17.5–18.5 of gestation, 1 day before the expected day of delivery, show an attenuated ACTH response to a novel environmental stress which is accompanied by a complete suppression of the induction of the immediate-early gene nur77 in the PVN (Douglas et al., 2003).
Positive_regulation (induction) of nur77 in D17 associated with stress
20) Confidence 0.29 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.48 Pain Relevance 0

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