INT47702

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Context Info
Confidence 0.76
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 7.60
Pain Relevance 11.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sptan1) plasma membrane (Sptan1) cytoskeleton (Sptan1)
protein complex (Sptan1) cytoplasm (Sptan1)
Anatomy Link Frequency
neurons 6
striatum 3
spinal cord 2
lymphoblasts 2
cleavage 1
Sptan1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 80 100.00 Very High Very High Very High
adenocard 80 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
Enkephalin 30 99.84 Very High Very High Very High
Dopamine 25 99.40 Very High Very High Very High
Spinal cord 8 98.84 Very High Very High Very High
Glutamate 576 98.80 Very High Very High Very High
Somatostatin 4 98.72 Very High Very High Very High
Morphine 16 98.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 76 100.00 Very High Very High Very High
Migraine With Aura 8 98.08 Very High Very High Very High
Cv Unclassified Under Development 4 97.44 Very High Very High Very High
Apoptosis 393 96.80 Very High Very High Very High
Brain Injury 4 96.56 Very High Very High Very High
Depression 2 96.52 Very High Very High Very High
Cough 236 93.20 High High
Death 323 92.72 High High
Stress 21 88.16 High High
Hyperalgesia 1 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also verified that the expression of alpha-fodrin, which was 1 of the 15 genes that were differentially expressed in lymphoblasts originating from patients with MA, increased after cortical spreading depression in an animal model.
Gene_expression (expression) of alpha-fodrin in lymphoblasts associated with depression and migraine with aura
1) Confidence 0.76 Published 2009 Journal Neurosci. Res. Section Abstract Doc Link 19428688 Disease Relevance 0.78 Pain Relevance 0.63
We also verified that the expression of alpha-fodrin, which was 1 of the 15 genes that were differentially expressed in lymphoblasts originating from patients with MA, increased after cortical spreading depression in an animal model.
Gene_expression (expressed) of alpha-fodrin in lymphoblasts associated with depression and migraine with aura
2) Confidence 0.76 Published 2009 Journal Neurosci. Res. Section Abstract Doc Link 19428688 Disease Relevance 0.78 Pain Relevance 0.64
The reduction in the number of labeled neurons seemed to occur predominantly in enkephalin-containing neurons, which coexpress adenosine A2A receptors and dopamine D2 receptors.
Gene_expression (coexpress) of A2A in neurons associated with dopamine, adenocard and enkephalin
3) Confidence 0.75 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.33
Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.
Gene_expression (Expression) of A 2A in spinal cord associated with adenocard and spinal cord
4) Confidence 0.75 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18499627 Disease Relevance 0.09 Pain Relevance 0.64
It is suggested that age alters the number of cells that express A2A receptors, the turnover of A1 receptors, and in some regions their coupling to G proteins, but that life-long intermittent ethanol exposure has little additional effect.
Gene_expression (express) of A2A
5) Confidence 0.75 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593882 Disease Relevance 0 Pain Relevance 0.26
Earlier studies suggested that dopamine D1 and mu opioid receptors that regulate adenylyl cyclase are expressed preferentially by striato-nigral neurons, whereas adenosine A2a and delta1 opioid receptors are expressed preferentially by striato-pallidal neurons.
Gene_expression (expressed) of A2a in neurons associated with adenocard, dopamine, mu opioid receptor and opioid receptor
6) Confidence 0.75 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 0.75
Thus chronic D1 blockade, like chronic morphine treatment, appears to cause a selective impairment of the regulation of adenylyl cyclase in A2a receptor-expressing striato-pallidal neurons.
Gene_expression (expressing) of A2a in neurons associated with morphine
7) Confidence 0.75 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 1.02
In contrast, clusters of silver grains were never detected overlying striatal cells containing pSRIF mRNA indicating that this population of interneurones do not express the adenosine A2a receptor sub-type.
Neg (not) Gene_expression (express) of A2a associated with adenocard
8) Confidence 0.75 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7912401 Disease Relevance 0 Pain Relevance 0.72
The A2a receptor is mainly expressed by neurons projecting to the globus pallidus and expressing also the dopamine D2 receptor and enkephalin, but very sparsely by neurons projecting to the substantia nigra that express the dopamine D1 receptor and substance P.
Gene_expression (expressed) of A2a in substantia nigra associated with dopamine, substantia nigra, enkephalin and substance p
9) Confidence 0.75 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7680065 Disease Relevance 0.06 Pain Relevance 0.57
The expression of adenosine A2a receptors by enkephalin cells in striatum suggests that adenosine may play a role in modulating the activity of GABA/enkephalin striatopallidal neurones through interaction with A2a receptors.
Gene_expression (expression) of A2a in striatum associated with gaba, adenocard and enkephalin
10) Confidence 0.75 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7912401 Disease Relevance 0 Pain Relevance 0.74
Moreover, the A2a receptor subtype is exclusively expressed in the striatum.
Gene_expression (expressed) of A2a in striatum
11) Confidence 0.75 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7680065 Disease Relevance 0 Pain Relevance 0.27
In situ hybridization histochemistry was used either in combination with retrograde labeling of striatonigral neurons to determine the projection site of A2a receptor expressing neurons, or on consecutive thin sections to address the putative coexpression of the A2a receptor with the D1 or D2 receptors in individual neurons.
Gene_expression (coexpression) of A2a in neurons
12) Confidence 0.75 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7680065 Disease Relevance 0 Pain Relevance 0.51
In situ hybridization histochemistry was used either in combination with retrograde labeling of striatonigral neurons to determine the projection site of A2a receptor expressing neurons, or on consecutive thin sections to address the putative coexpression of the A2a receptor with the D1 or D2 receptors in individual neurons.
Gene_expression (expressing) of A2a in neurons
13) Confidence 0.65 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7680065 Disease Relevance 0 Pain Relevance 0.49
The cellular expression of the two mRNAs was consistently found to be concordant demonstrating that adenosine A2a receptor mRNA is expressed by medium-sized striatal enkephalin cells.
Gene_expression (expressed) of A2a associated with adenocard and enkephalin
14) Confidence 0.65 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7912401 Disease Relevance 0 Pain Relevance 0.70
Adenosine A2a receptor mRNA is expressed by enkephalin cells but not by somatostatin cells in rat striatum: a co-expression study.
Neg (not) Gene_expression (expressed) of A2a in striatum associated with adenocard, somatostatin and enkephalin
15) Confidence 0.65 Published 1994 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7912401 Disease Relevance 0 Pain Relevance 0.50
Previous studies have shown that dopamine D1 receptors are preferentially expressed in striatonigral neurons, while adenosine A2a receptors are preferentially expressed in striatopallidal neurons.
Gene_expression (expressed) of A2a in neurons associated with adenocard and dopamine
16) Confidence 0.65 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.22 Pain Relevance 0.56
-fodrin breakdown patterns produced by calpain or caspase-3, the effects of calpain and caspase inhibitors on glutamate-induced cleavage of ?
Gene_expression (produced) of fodrin in cleavage associated with glutamate
17) Confidence 0.40 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.26 Pain Relevance 0.29
-fodrin and DNA fragmentation have been detected following these insults.
Gene_expression (detected) of fodrin
18) Confidence 0.40 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.77 Pain Relevance 0.24
-fodrin breakdown products 145 kDa or/and 150 KDa (145/150 kDa BDPs) and caspase-produced ?
Gene_expression (products) of fodrin
19) Confidence 0.40 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.13 Pain Relevance 0.20
-fodrin band and following treatment with glutamate, the 240 KDa band was cleaved into 145 KDa BDP, but not the ?
Gene_expression (band) of fodrin in band associated with glutamate
20) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.24 Pain Relevance 0.23

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