INT47704

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 2.43
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
brain 2
dorsal horn 2
spinal cord 1
nerve 1
lamina 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 100.00 Very High Very High Very High
Morphine 14 99.08 Very High Very High Very High
Pain 89 98.20 Very High Very High Very High
Spinal cord 18 97.56 Very High Very High Very High
nMDA receptor 6 97.08 Very High Very High Very High
Hippocampus 10 96.76 Very High Very High Very High
Dorsal horn 168 96.68 Very High Very High Very High
antidepressant 5 95.96 Very High Very High Very High
Inflammation 131 95.72 Very High Very High Very High
intrathecal 35 94.48 High High
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 6 99.28 Very High Very High Very High
Pain 84 98.20 Very High Very High Very High
Aids-related Complex 6 96.62 Very High Very High Very High
INFLAMMATION 131 95.72 Very High Very High Very High
Hyperalgesia 17 90.48 High High
Arthritis 21 89.32 High High
Inflammatory Pain 25 85.88 High High
Peripheral Arterial Disease 2 76.56 Quite High
Toxicity 8 75.24 Quite High
Nociception 14 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, biphasic changes in locomotion induced by caffeine are paralleled by biphasic changes in mRNA for NGFI-A, NGFI-B, and jun B.
Regulation (changes) of NGFI-A
1) Confidence 0.60 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.37
Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.
Regulation (effects) of NGFI-A associated with antidepressant
2) Confidence 0.44 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.27
A developmentally regulated nerve growth factor-induced gene, VGF, is expressed in geniculocortical afferents during synaptogenesis.
Regulation (regulated) of nerve growth factor-induced in nerve associated with nerve growth factor
3) Confidence 0.29 Published 1995 Journal Neuroscience Section Title Doc Link 7617174 Disease Relevance 0 Pain Relevance 0.14
Eight hours following noxious heat plus morphine application we did not detect noxious evoked immunoreactivity for c-Fos, Krox-24, c-Jun and Jun B, while there was residual labelling for Fos B in the superficial dorsal horn and for Jun D in laminae I-VII and X of the spinal cord.
Neg (not) Regulation (immunoreactivity) of Krox-24 in dorsal horn associated with dorsal horn, spinal cord and morphine
4) Confidence 0.29 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152542 Disease Relevance 0 Pain Relevance 1.15
On the other hand, there was little effect of MK-801 administration on Zif/268 and c-Fos immunoreactivity in the nucleus proprius and deep lamina V of the trigeminal nucleus caudalis, while most neurons expressing Zif/268 or c-Fos in these two regions were labeled by NR1.
Regulation (immunoreactivity) of Zif/268 in nucleus associated with nmda receptor
5) Confidence 0.25 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 14596893 Disease Relevance 0.15 Pain Relevance 0.46
The immediate early genes (IEG), FBJ murine osteosarcoma viral oncogene homolog (c-fos) and early growth response 1 (Egr1) were differentially affected by the two pyrethroids at 6 h post-exposure, however, no significant main effect of dose (EDL) was observed for either compound.
Regulation (affected) of Egr1 associated with osteogenic sarcomas
6) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0
The immediate early genes (IEG), FBJ murine osteosarcoma viral oncogene homolog (c-fos) and early growth response 1 (Egr1) were differentially affected by the two pyrethroids at 6 h post-exposure, however, no significant main effect of dose (EDL) was observed for either compound.
Regulation (affected) of early growth response 1 associated with osteogenic sarcomas
7) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0
Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.
Regulation (changes) of Egr1
8) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03
All drugs produced marked reductions of formalin-induced c-Fos and Zif/268 immunoreactivity in laminae I and II, and laminae V and VI in the rat lumbar spinal cord.
Regulation (immunoreactivity) of Zif/268 in spinal cord associated with spinal cord
9) Confidence 0.25 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12223232 Disease Relevance 0.07 Pain Relevance 0.57
Numerous studies also support a role for Fos and Zif268, a transcription factor essential for the maintenance of longer term LTP in the hippocampus, in the initiation and maintenance of pain states [8,9].
Regulation (role) of Zif268 in hippocampus associated with pain and hippocampus
10) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.48 Pain Relevance 0.59
Changes in P-MeCP2, Zif268 and Fos expression were quantified by immunohistochemistry.
Regulation (Changes) of Zif268
11) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.06 Pain Relevance 0.21
Crucially, P-MeCP2, Zif268 and Fos are all up-regulated in lamina I, NK1 positive, projection neurones following peripheral noxious stimulation: after peripheral inflammation 47% and 27% of projection neurones expressed Zif268 [30] and P-MeCP2 [7] respectively.
Regulation (regulated) of Zif268 in lamina associated with inflammation
12) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.39
When we plotted the mean number per dorsal horn section, ipsilateral to the CFA injection, of P-MeCP2 positive nuclei against the number of Zif268 or Fos positive nuclei for individual animals for this experiment (N = 10), the correlation was stronger between P-MeCP2 and Zif268 (correlation coefficient: R2 = 0.8) than between P-MeCP2 and Fos (R2 = 0.4), suggesting a parallel regulation for P-MeCP2 and Zif268 (Figure 8).


Regulation (regulation) of Zif268 in dorsal horn associated with dorsal horn
13) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.39 Pain Relevance 0.43
Samples were analyzed for BDNF induced transcripts using Taqman expression assays (Applied Biosystems) as follows: beta-actin (Actb), Rn00667869_m1; activity regulated cytoskeletal-associated protein (Arc), Rn00571208_g1; brain-specific angiogenesis inhibitor 1-associated protein 2 (Baiap2), Rn00589411_m1; dual specificity phosphatase 6 (Dusp6), Rn00518185_m1; early growth response 1 (Egr1), Rn00561138_m1; early growth response 2 (Egr2), Rn00586224_m1; Kruppel-like factor 5 (Klf5), Rn00821442_g1; Ngfi-A binding protein 2 (Nab2), Rn01505957_g1; prepronociceptin (Pnoc), Rn00564560_m1; protein phosphatase 2C, magnesium dependent catalytic subunit (Ppm2c), Rn00571345_m1; synaptotagmin IV (Syt4), Rn01157571_m1; tachykinin 1 (Tac1), Rn00562002_m1.
Regulation (th respo) of Egr1 in brain associated with aids-related complex
14) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.10 Pain Relevance 0
The possibility that Fos is a target gene for MeCP2 has been excluded by previous in vitro studies [6] and recent studies of gene expression changes in brain tissue of MeCP2 deficient mice failed to report any changes in Fos and Zif268 mRNA [26].
Regulation (changes) of Zif268 mRNA in brain
15) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.34 Pain Relevance 0.51
was shown to be closely dependent on the transcription factor early growth response factor-1 (Egr-1) [57], although activator protein-1 and specificity protein-1 binding sites were also found [62].
Regulation (dependent) of early growth response factor-1
16) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.04
was shown to be closely dependent on the transcription factor early growth response factor-1 (Egr-1) [57], although activator protein-1 and specificity protein-1 binding sites were also found [62].
Regulation (dependent) of Egr-1
17) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.04

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