INT47706

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 6.11
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
monocytes 2
endothelial cell 2
colon 2
THP-1 2
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 9 100.00 Very High Very High Very High
Inflammation 30 99.98 Very High Very High Very High
tetrodotoxin 3 99.98 Very High Very High Very High
agonist 10 99.90 Very High Very High Very High
cINOD 13 99.80 Very High Very High Very High
Serotonin 6 99.72 Very High Very High Very High
Dopamine 11 99.24 Very High Very High Very High
cytokine 16 99.08 Very High Very High Very High
antagonist 7 98.96 Very High Very High Very High
adenocard 2 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 70 100.00 Very High Very High Very High
Depression 9 100.00 Very High Very High Very High
Alzheimer's Dementia 6 100.00 Very High Very High Very High
Colon Cancer 4 100.00 Very High Very High Very High
INFLAMMATION 34 99.98 Very High Very High Very High
Hypoxia 1 99.20 Very High Very High Very High
Cognitive Disorder 14 96.84 Very High Very High Very High
Disease 15 96.80 Very High Very High Very High
Nociception 2 94.48 High High
Apoptosis 4 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).
Negative_regulation (decrease) of Positive_regulation (caused) of NGFI-A associated with agonist
1) Confidence 0.41 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.39
Prazosin reduced FCL(SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA.
Negative_regulation (reduced) of Positive_regulation (elevations) of NGFI-A associated with depression
2) Confidence 0.41 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.61 Pain Relevance 0.68
In contrast, tetrodotoxin abolished induction of c-fos and zif268 messenger RNAs by the D2 antagonist eticlopride (0.5 mg/kg, i.p.) in both intact rats and dopamine-depleted rats receiving continuous D2 agonist treatment (quinpirole, 0.5 mg/kg/day).
Negative_regulation (abolished) of Positive_regulation (induction) of zif268 associated with tetrodotoxin, dopamine, antagonist and agonist
3) Confidence 0.37 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077330 Disease Relevance 0 Pain Relevance 0.90
shown histochemically by the upregulation of Arc, Zif268, and to a lesser
Negative_regulation (shown) of Positive_regulation (upregulation) of Zif268 associated with aids-related complex
4) Confidence 0.36 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.84 Pain Relevance 0
1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1.
Negative_regulation (decrease) of Positive_regulation (activation) of early growth response-1 in colon associated with inflammation, colon cancer, cinod, agonist and cytokine
5) Confidence 0.17 Published 2005 Journal Mol. Pharmacol. Section Title Doc Link 16155208 Disease Relevance 0.53 Pain Relevance 0.31
Expression of inflammation-induced Zif268 was also attenuated after serotonin depletion, in parallel with mechanical sensitivity.
Negative_regulation (attenuated) of Positive_regulation (induced) of Zif268 associated with inflammation and serotonin
6) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.74 Pain Relevance 0.78
We determined whether curcumin, a natural product known to have anti-inflammatory properties, suppressed Egr-1 activation and concomitant expression of cytochemokines.
Spec (whether) Negative_regulation (suppressed) of Spec (whether) Positive_regulation (activation) of Egr-1 associated with inflammation
7) Confidence 0.12 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.80 Pain Relevance 0.42
We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.
Negative_regulation (suppresses) of Positive_regulation (activation) of Egr-1 in THP-1
8) Confidence 0.12 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.76 Pain Relevance 0.41
Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor.
Negative_regulation (inhibits) of Positive_regulation (modulating) of early growth response-1 in monocytes associated with alzheimer's dementia and cytokine
9) Confidence 0.12 Published 2004 Journal J. Neurochem. Section Title Doc Link 15569263 Disease Relevance 0.91 Pain Relevance 0.56
Some of these mechanisms include: inhibition of mitogen-activated protein (Erk2) kinase activity; suppression of cell cycle proteins; inhibition of early growth response (Egr-1) gene activation; interference with hypoxia inducible factor 1 and VEGF gene activation; increased production of the angiogenesis inhibitor, endostatin; inhibition of endothelial cell proliferation, migration, and spreading; and induction of endothelial apoptosis.
Negative_regulation (inhibition) of Positive_regulation (activation) of early growth response in endothelial cell associated with hypoxia and apoptosis
10) Confidence 0.04 Published 2003 Journal J. Mol. Med. Section Abstract Doc Link 13679997 Disease Relevance 0.92 Pain Relevance 0.66

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