INT47707

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.17
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
spinal cord 2
neurons 2
caudate-putamen 2
spinal 1
dorsal horn 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 4 100.00 Very High Very High Very High
Spinal cord 19 99.96 Very High Very High Very High
Morphine 25 99.90 Very High Very High Very High
Clonidine 2 99.70 Very High Very High Very High
Enkephalin 15 99.56 Very High Very High Very High
Hippocampus 2 99.26 Very High Very High Very High
Dopamine 14 99.24 Very High Very High Very High
spinal dorsal horn 6 99.08 Very High Very High Very High
amygdala 2 98.68 Very High Very High Very High
adenocard 2 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).
Negative_regulation (decrease) of NGFI-A associated with agonist
1) Confidence 0.41 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.38
Methoxyidazoxan significantly increased (mean%) NGFI-A mRNA in: cerebral cortex (44); caudate putamen (82); amygdala (92); and CA1 of hippocampus (48), while clonidine significantly decreased NGFI-A mRNA in the various cortical layers to a similar extent (27-37%).
Negative_regulation (decreased) of NGFI-A in hippocampus associated with hippocampus, amygdala, cerebral cortex and clonidine
2) Confidence 0.41 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.69
Intravenous injection of Kelatorphan (5, 10 and 20 mg/kg), an inhibitor of multiple enkephalin-degrading enzymes, 20 min before noxious stimulation reduced the overall number of dorsal horn neurons expressing c-FOS and NGF1-A by up to 20-30%.
Negative_regulation (reduced) of NGF1 in dorsal horn associated with enkephalin and dorsal horn neuron
3) Confidence 0.41 Published 1994 Journal Pain Section Abstract Doc Link 8159434 Disease Relevance 0 Pain Relevance 0.78
While c-FOS expression was suppressed in superficial and deep laminae of the spinal cord, NGF1-A and c-JUN was only suppressed in superficial laminae.
Negative_regulation (suppressed) of NGF1 in spinal cord associated with spinal cord
4) Confidence 0.41 Published 1994 Journal Pain Section Abstract Doc Link 8159434 Disease Relevance 0 Pain Relevance 0.91
Combined D1 and D2 agonist treatment further increased zif268 mRNA levels in this population of enkephalin-negative neurons and decreased zif-268 mRNA levels in enkephalin-positive neurons.
Negative_regulation (decreased) of zif-268 mRNA in neurons associated with agonist and enkephalin
5) Confidence 0.32 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 8613751 Disease Relevance 0 Pain Relevance 0.89
At 2 h following noxious heat stimulation morphine had decreased the number of labelled neurons for c-Fos, Fos B, Krox-24, c-Jun and Jun B to 30-60% of control levels in laminae I-II and to 10-30% in laminae III-VII,X of the spinal cord.
Negative_regulation (decreased) of Krox-24 in neurons associated with spinal cord and morphine
6) Confidence 0.27 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152542 Disease Relevance 0 Pain Relevance 1.17
In situ hybridization experiments in the caudate-putamen indicated that SR48692 (10 mg/kg) markedly reduced zif268 mRNA labelling produced by SKF38393 plus quinpirole in cells not expressing enkephalin mRNA, but was unable to affect the concomitant decrease of zif268 mRNA labelling in enkephalin-positive cells.
Negative_regulation (decrease) of zif268 mRNA in caudate-putamen associated with enkephalin
7) Confidence 0.21 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10103090 Disease Relevance 0 Pain Relevance 0.53
In situ hybridization experiments in the caudate-putamen indicated that SR48692 (10 mg/kg) markedly reduced zif268 mRNA labelling produced by SKF38393 plus quinpirole in cells not expressing enkephalin mRNA, but was unable to affect the concomitant decrease of zif268 mRNA labelling in enkephalin-positive cells.
Negative_regulation (reduced) of zif268 mRNA in caudate-putamen associated with enkephalin
8) Confidence 0.21 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10103090 Disease Relevance 0 Pain Relevance 0.56
Endomorphins suppress nociception-induced c-Fos and Zif/268 expression in the rat spinal dorsal horn.
Negative_regulation (suppress) of Zif/268 in spinal associated with nociception and spinal dorsal horn
9) Confidence 0.18 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12223232 Disease Relevance 0.10 Pain Relevance 0.55
All drugs produced marked reductions of formalin-induced c-Fos and Zif/268 immunoreactivity in laminae I and II, and laminae V and VI in the rat lumbar spinal cord.
Negative_regulation (reductions) of Zif/268 in spinal cord associated with spinal cord
10) Confidence 0.18 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12223232 Disease Relevance 0.07 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox