INT47708

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 30
Total Number 37
Disease Relevance 5.12
Pain Relevance 13.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
striatum 7
nerve 2
neurons 2
plasma 1
brain 1
Nr4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 17 100.00 Very High Very High Very High
Enkephalin 108 99.88 Very High Very High Very High
Dopamine 658 99.76 Very High Very High Very High
withdrawal 20 99.62 Very High Very High Very High
Dynorphin 58 99.52 Very High Very High Very High
qutenza 3 99.20 Very High Very High Very High
agonist 82 99.14 Very High Very High Very High
antagonist 9 98.94 Very High Very High Very High
Opioid 2 98.72 Very High Very High Very High
Hippocampus 79 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 91 100.00 Very High Very High Very High
Reperfusion Injury 4 98.84 Very High Very High Very High
Parkinson's Disease 7 98.36 Very High Very High Very High
INFLAMMATION 5 98.28 Very High Very High Very High
Apoptosis 24 98.24 Very High Very High Very High
Drug Dependence 12 97.16 Very High Very High Very High
Stress 30 94.56 High High
Shock 3 94.00 High High
Schizophrenia 5 92.60 High High
Death 83 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, using a double in situ hybridization technique, we show that acute administration of both neuroleptics increases NGFI-B expression in neurotensin-containing neurons in the nucleus accumbens shell, whereas the effects of haloperidol in the dorsolateral striatum are mainly observed in enkephalin-containing neurons.
Gene_expression (expression) of NGFI-B in neurons associated with nucleus accumbens and enkephalin
1) Confidence 0.78 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.06 Pain Relevance 0.25
In contrast, chronic treatment with clozapine reduces NGFI-B expression below basal levels in the rat forebrain, whereas haloperidol still induces high NGFI-B mRNA levels in the dorsolateral striatum.
Gene_expression (expression) of NGFI-B in striatum
2) Confidence 0.78 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.07 Pain Relevance 0.22
However, haloperidol, but not clozapine, dramatically increases NGFI-B expression in the dorsolateral striatum.
Gene_expression (expression) of NGFI-B in striatum
3) Confidence 0.78 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.07 Pain Relevance 0.22
Using in situ hybridization, we also demonstrate that typical and atypical antipsychotics induced contrasting patterns of expression of NGFI-B after both acute and chronic administration.
Gene_expression (expression) of NGFI-B
4) Confidence 0.78 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.08 Pain Relevance 0.12
Additional acute studies were performed in normal rats to determine the role of the denervation process in the coordinate expression of NGFI-B in striatal subpopulations.
Gene_expression (expression) of NGFI-B
5) Confidence 0.77 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.60
In this study, we have investigated the effects of denervation and repeated L-DOPA administration on the expression of the nuclear receptor nerve growth factor inducible-B (NGFI-B) in striatal output pathways of unilaterally 6-OHDA-lesioned rats.
Gene_expression (expression) of NGFI-B in nerve associated with nerve growth factor
6) Confidence 0.77 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.46
Denervation and repeated L-DOPA induce a coordinate expression of the transcription factor NGFI-B in striatal projection pathways in hemi-parkinsonian rats.
Gene_expression (expression) of NGFI-B associated with parkinson's disease and enkephalin
7) Confidence 0.77 Published 2003 Journal Neurobiol. Dis. Section Title Doc Link 13678671 Disease Relevance 0.10 Pain Relevance 0.63
A combination of selective D(1) and D(2) agonists induced an important increase of striatal NGFI-B expression selectively in DYN-containing neurons.
Gene_expression (expression) of NGFI-B in neurons associated with dynorphin and agonist
8) Confidence 0.77 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.59
On the intact side, repeated L-DOPA treatment increased NGFI-B expression in both striatal subpopulations.
Gene_expression (expression) of NGFI-B
9) Confidence 0.77 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.61
The values in the SL group were also comparable to those measured on the lesioned side after METH (ML group) administration, implying that METH did not influence Nr4a1 expression in the absence of DA.
Gene_expression (expression) of Nr4a1 associated with dopamine
10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.11
Therefore, there might exist a certain correspondence between DA depletion, Nur77 expression, and up-regulated transcripts of some of the identified genes in the hemiparkinsonian brain.
Gene_expression (expression) of Nur77 in brain associated with dopamine
11) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.46
We found significant increases in the expression of Nr4a1 (Nur77) in the denervated striatum in comparison to the intact side (SL vs SNL) of hemiparkinsonian rats.
Gene_expression (expression) of Nr4a1 in striatum
12) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.20
We found significant increases in the expression of Nr4a1 (Nur77) in the denervated striatum in comparison to the intact side (SL vs SNL) of hemiparkinsonian rats.
Gene_expression (expression) of Nur77 in striatum
13) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.20
The denervation process induced NT and Nur77 mRNA expression in ENK-positive cells.
Gene_expression (expression) of Nur77 mRNA associated with enkephalin
14) Confidence 0.69 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.07 Pain Relevance 0.63
We looked at the territorial patterns of expression of neurotensin (NT), dynorphin (DYN), enkephalin (ENK) and Nur77 (also known as NGFI-B) mRNA expression in the striatum and contrasted these with markers of glutamatergic transport and dopaminergic receptor functions.
Gene_expression (expression) of Nur77 in striatum associated with dynorphin and enkephalin
15) Confidence 0.69 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.08 Pain Relevance 0.57
In this study, we have investigated the effects of denervation and repeated L-DOPA administration on the expression of the nuclear receptor nerve growth factor inducible-B (NGFI-B) in striatal output pathways of unilaterally 6-OHDA-lesioned rats.
Gene_expression (expression) of nerve growth factor inducible-B in nerve associated with nerve growth factor
16) Confidence 0.67 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.45
NGFI-A, NGFI-B and Nurr1 expression persisted for 6 h.
Gene_expression (expression) of NGFI-B
17) Confidence 0.67 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.48 Pain Relevance 0.36
Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.
Gene_expression (expression) of NGFI-B associated with antidepressant
18) Confidence 0.66 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.28
NGFI-B, a member of the nuclear receptor family, can be observed in target structures of dopaminergic pathways.
Gene_expression (observed) of NGFI-B
19) Confidence 0.60 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987852 Disease Relevance 0.09 Pain Relevance 0.12
The time course of expression of mRNA for NGFI-A and NGFI-B after a single intraperitoneal injection of saline or caffeine was examined using in situ hybridization.
Spec (examined) Gene_expression (expression) of NGFI-B
20) Confidence 0.60 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0

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