INT47709

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
cortex 1
Nr4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2 99.24 Very High Very High Very High
Nucleus accumbens 35 98.56 Very High Very High Very High
adenocard 5 98.16 Very High Very High Very High
cocaine 105 97.68 Very High Very High Very High
agonist 1 97.20 Very High Very High Very High
Enkephalin 1 96.32 Very High Very High Very High
antidepressant 5 95.52 Very High Very High Very High
Eae 1 91.88 High High
Neuropeptide 3 90.16 High High
cerebral cortex 1 86.88 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 11 100.00 Very High Very High Very High
Osteogenic Sarcomas 2 89.00 High High
Cocaine Dependence 10 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease of mRNA for NGFI-A, NGFI-B, and jun B caused by caffeine (25 mg/kg) could be mimicked by the D2 agonist quinpirole (1 and 3 mg/kg).
Negative_regulation (decrease) of NGFI-B associated with agonist
1) Confidence 0.59 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.38
NGFI-B mRNA was significantly decreased in the hippocampal CA3 subfield (23%) and restrosplenial granular cortex (38%) by moclobemide treatment.
Negative_regulation (decreased) of NGFI-B mRNA in cortex
2) Confidence 0.50 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.32
Persistent decreases (Category 2 or 3) in Arc, Fos, and Nr4a1 were observed in both the mPFC and NAc.
Negative_regulation (decreases) of Nr4a1 associated with nucleus accumbens and aids-related complex
3) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.27 Pain Relevance 0.22

General Comments

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