INT47710

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 71
Total Number 73
Disease Relevance 25.57
Pain Relevance 34.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
brain 7
spinal 3
neuron 3
dorsal 1
margin 1
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 453 100.00 Very High Very High Very High
depression 358 100.00 Very High Very High Very High
Glutamate 313 100.00 Very High Very High Very High
antagonist 178 100.00 Very High Very High Very High
Glutamate receptor 42 99.96 Very High Very High Very High
gABA 256 99.84 Very High Very High Very High
ketamine 195 99.84 Very High Very High Very High
5HT 26 99.84 Very High Very High Very High
spinothalamic tract 7 99.84 Very High Very High Very High
excitatory amino acid 9 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 381 100.00 Very High Very High Very High
Autism 664 99.84 Very High Very High Very High
Dyspepsia 5 99.52 Very High Very High Very High
Stress 183 99.44 Very High Very High Very High
Poisoning 38 99.42 Very High Very High Very High
Apoptosis 21 99.40 Very High Very High Very High
Targeted Disruption 16 99.38 Very High Very High Very High
Death 70 99.36 Very High Very High Very High
Pain 67 99.28 Very High Very High Very High
Anxiety Disorder 693 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.
Negative_regulation (Blockade) of NMDA in brain associated with nmda receptor and apoptosis
1) Confidence 0.57 Published 1999 Journal Science Section Title Doc Link 9872743 Disease Relevance 0.47 Pain Relevance 0.37
NMDA receptors were inhibited in a concentration-dependent manner.
Negative_regulation (inhibited) of NMDA associated with nmda receptor
2) Confidence 0.57 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15845694 Disease Relevance 0 Pain Relevance 1.37
The antinociceptive and antihyperalgesic effect of (-)-linalool has been ascribed to the stimulation of the cholinergic, opioidergic and dopaminergic systems, to its local anaesthetic activity and to the blockade of N-Methyl-d-aspartate receptors (NMDA).
Negative_regulation (blockade) of NMDA associated with antihyperalgesic and antinociceptive
3) Confidence 0.57 Published 2006 Journal Life Sci. Section Abstract Doc Link 16137709 Disease Relevance 0.36 Pain Relevance 0.36
Volatile anesthetics inhibited NR1/NR2A and NR1/NR2B glutamate receptor function in a reversible, concentration-dependent, voltage-insensitive and noncompetitive manner (half-maximal inhibitory concentration at NR1/NR2A receptors: 1.30 +/- 0.02 minimum alveolar anesthetic concentration [MAC] for isoflurane, 1.18 +/- 0.03 MAC for desflurane, 1.24 +/- 0.06 MAC for sevoflurane; at NR1/NR2B receptors: 1.33 +/- 0.12 MAC for isoflurane, 1.22 +/- 0.08 MAC for desflurane, and 1.28 +/- 0.08 MAC for sevoflurane).
Negative_regulation (inhibited) of NR1 associated with glutamate receptor and isoflurane
4) Confidence 0.57 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.47
Volatile anesthetics inhibited NR1/NR2A and NR1/NR2B glutamate receptor function in a reversible, concentration-dependent, voltage-insensitive and noncompetitive manner (half-maximal inhibitory concentration at NR1/NR2A receptors: 1.30 +/- 0.02 minimum alveolar anesthetic concentration [MAC] for isoflurane, 1.18 +/- 0.03 MAC for desflurane, 1.24 +/- 0.06 MAC for sevoflurane; at NR1/NR2B receptors: 1.33 +/- 0.12 MAC for isoflurane, 1.22 +/- 0.08 MAC for desflurane, and 1.28 +/- 0.08 MAC for sevoflurane).
Negative_regulation (inhibited) of NR1 associated with glutamate receptor and isoflurane
5) Confidence 0.57 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.50
In particular, inhibitors of the NMDA glutamate receptor such as ketamine and agonists at the mu-opioid receptor such as morphine are broadly used.
Negative_regulation (inhibitors) of NMDA associated with ketamine, glutamate receptor, agonist, opioid receptor and morphine
6) Confidence 0.57 Published 2010 Journal Brain Behav. Immun. Section Abstract Doc Link 20006700 Disease Relevance 1.06 Pain Relevance 1.23
Conantokins are small peptides (17-27 amino acids) found in the venoms of cone snails (Conus sp.) that inhibit the activity of N-methyl-D-aspartate (NMDA) receptors.
Negative_regulation (inhibit) of NMDA
7) Confidence 0.42 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 15579001 Disease Relevance 0 Pain Relevance 0.10
Phencyclidine (PCP) produces schizophrenia-like psychosis and acute PCP-intoxications; however, whether glutamate/NMDA-receptor blockade by PCP modulates or not these mechanisms has remained to be clarified.
Spec (whether) Negative_regulation (blockade) of NMDA-receptor associated with glutamate, psychosis, poisoning and schizophrenia
8) Confidence 0.42 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15215646 Disease Relevance 0.45 Pain Relevance 0.66
In the latter study, TDS stress induced a significant down-regulation of hippocampal NMDA receptors.
Negative_regulation (regulation) of NMDA associated with stress and nmda receptor
9) Confidence 0.42 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.98 Pain Relevance 0.56
The inhibitory effect on NMDA receptors may contribute to the antinociceptive effect of tramadol at relatively large concentrations.
Negative_regulation (effect) of NMDA associated with tramadol, nmda receptor and antinociceptive
10) Confidence 0.42 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15845694 Disease Relevance 0 Pain Relevance 1.22
We interpret these results as a de-sensitizing effect in the long term of repeated NMDA-receptor blockade by ketamine in a chronic pain state, with indications of central sensitization, partially maintained by sympathetic activity.
Negative_regulation (blockade) of NMDA-receptor in sympathetic associated with central sensitization, ketamine and lasting pain
11) Confidence 0.42 Published 1995 Journal Pain Section Abstract Doc Link 7784107 Disease Relevance 1.55 Pain Relevance 1.33
In this nucleus, ethanol inhibits the presynaptic release of glutamate through opioid mechanisms and reduces post-synaptic glutamatergic transmission through inhibition of both NMDA-mediated and kainate-mediated currents [131].
Negative_regulation (inhibition) of NMDA in nucleus associated with glutamate and opioid
12) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 0 Pain Relevance 0.70
Ethanol-induced NMDA inhibition in the cerebral cortex results in the reduction of noradrenaline and acetylcholine [136], and this might be related to the development of depression.
Negative_regulation (inhibition) of NMDA in cerebral cortex associated with depression, noradrenaline and cerebral cortex
13) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 0.56 Pain Relevance 0.75
All experiments measuring the I–V relationship were carried out in the presence of picrotoxin (100 µM) and D,L-APV (100 µM) in order to block GABAA and NMDA receptors, respectively.
Negative_regulation (block) of NMDA associated with nmda receptor
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013137 Disease Relevance 0 Pain Relevance 0.15
In six neurones excitatory postsynaptic potentials mediated by AMPA receptors (AMPAr) were isolated by blockade of NMDA-receptors (NMDAr, 2-AP5), GABAAr (bicuculline) and GABAB-receptors (GABABr, CGP 55845A).
Negative_regulation (blockade) of NMDA
15) Confidence 0.41 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.18
Blockade of spinal NMDA receptors prior to the second injection intramuscular acid injection delays the onset of hyperalgesia, where as the maintenance phase of hyperalgesia, evaluated 1 week after the second intramuscular injection, is dependent on activation of spinal AMPA/kainate and NMDA receptors.
Negative_regulation (Blockade) of NMDA in spinal associated with hyperalgesia and nmda receptor
16) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 16297556 Disease Relevance 0.54 Pain Relevance 0.88
Since the synapses between first- and second-order trigeminal neurons are presumed to be mediated by excitatory amino acids, postsynaptic NMDA receptors should be inhibited by kynurenic acid, an endogenous NMDA receptor antagonist.
Negative_regulation (inhibited) of NMDA in neurons associated with nmda receptor antagonist, nmda receptor and excitatory amino acid
17) Confidence 0.41 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17382471 Disease Relevance 0.41 Pain Relevance 0.48
Altogether, these data indicate that the EA-mediated attenuation of chronic visceral hypersensitivity is correlated with the down-regulation of NMDA receptors phosphorylation at the spinal level.
Negative_regulation (down-regulation) of NMDA in spinal associated with nmda receptor, nud and acupuncture
18) Confidence 0.41 Published 2008 Journal Life Sci. Section Abstract Doc Link 18694764 Disease Relevance 0.55 Pain Relevance 1.06
Previously, we have shown that felbamate can decrease sEPSC frequency by blocking presynaptic facilitatory NMDA autoreceptors (Yang et al., 2007).
Negative_regulation (blocking) of NMDA
19) Confidence 0.41 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.33
CaMKII, a co-resident with NMDA receptors and nNOS at synapses (Kennedy, 2000), was found to phosphorylate the enzyme on serine-847 and inhibit NO formation by ?
Negative_regulation (receptors) of NMDA in synapses associated with nmda receptor
20) Confidence 0.41 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.19

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