INT47712

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2011
Negated 5
Speculated 3
Reported most in Body
Documents 135
Total Number 142
Disease Relevance 101.38
Pain Relevance 28.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 8
cleavage 7
hippocampus 5
neurons 5
plasma 3
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 277 100.00 Very High Very High Very High
agonist 102 99.98 Very High Very High Very High
Inflammation 853 99.82 Very High Very High Very High
Glutamate receptor 76 99.72 Very High Very High Very High
dexamethasone 7 99.68 Very High Very High Very High
Hippocampus 631 99.60 Very High Very High Very High
narcan 8 99.52 Very High Very High Very High
Intracerebroventricular 6 99.44 Very High Very High Very High
cerebral cortex 111 99.40 Very High Very High Very High
cytokine 241 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 4318 100.00 Very High Very High Very High
Targeted Disruption 3284 100.00 Very High Very High Very High
Alzheimer's Dementia 2798 100.00 Very High Very High Very High
Amyloid Plaque 782 100.00 Very High Very High Very High
Urological Neuroanatomy 57 100.00 Very High Very High Very High
Hypoxia 114 99.98 Very High Very High Very High
Drug Induced Neurotoxicity 118 99.96 Very High Very High Very High
INFLAMMATION 1074 99.82 Very High Very High Very High
Brain Injury 115 99.78 Very High Very High Very High
Stress 766 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alteration of axonal transport has been considered to be the possible cause of these changes: spheroids and myelin ovoids, axonal accumulation of APP, neurofilament and ubiquitin are observed in the white matter of the spinal cord [337] in the APP × PS1 and APP × PS1—Ki lines developed by Sanofi-Aventis [26, 336, 337].
Positive_regulation (accumulation) of APP in white matter associated with spinal cord
1) Confidence 0.69 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.42 Pain Relevance 0.15
Intriguingly, we also found that stress-responsive increases in APP expression levels occurred only in the hippocampus of female 5XFAD mice.
Positive_regulation (increases) of APP in hippocampus associated with stress and hippocampus
2) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.79 Pain Relevance 0.11
There are increased APP mRNA levels in the cerebral cortex, hippocampus, and cerebellum in a FXS mouse model [32], and FXR1P, an FMRP homolog, is an AU-rich element–binding protein that binds to and regulates TNF?
Positive_regulation (increased) of APP mRNA in cerebellum associated with syndrome, hippocampus and cerebral cortex
3) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.71 Pain Relevance 0.10
We would predict that constitutively upregulated APP would lead to increased processing to A?.
Positive_regulation (upregulated) of APP
4) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.69 Pain Relevance 0
Protease inhibitors increased steady-state levels of APP in WT SNs to those seen in KO SNs (unpublished data).
Positive_regulation (increased) of APP associated with targeted disruption
5) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.75 Pain Relevance 0
There was a 21% increase in the basal level of APP in untreated fmr-1 KO neurons compared to WT (Figure 5B).
Positive_regulation (increase) of APP in neurons associated with targeted disruption
6) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.89 Pain Relevance 0
In cultured cells, the decrease in Abeta42 secretion was accompanied by an increase in the Abeta(1-38) isoform, indicating that NSAIDs subtly alter gamma-secretase activity without significantly perturbing other APP processing pathways or Notch cleavage.
Positive_regulation (increase) of Abeta in cleavage associated with cinod and abeta
7) Confidence 0.67 Published 2001 Journal Nature Section Abstract Doc Link 11700559 Disease Relevance 0.46 Pain Relevance 0.80
Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase.
Positive_regulation (derived) of Abeta associated with alzheimer's dementia and abeta
8) Confidence 0.60 Published 2005 Journal Drugs Aging Section Abstract Doc Link 16506440 Disease Relevance 0.86 Pain Relevance 0.18
Similar to changes in BACE1 levels, the stress treatment significantly elevated levels of hippocampal full-length APP in female 5XFAD mice [F(1,14) = 32.47, p < 0.0001] (Figure 3F) but not in male 5XFAD mice (Figure 3E).
Positive_regulation (elevated) of APP associated with stress
9) Confidence 0.60 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.42 Pain Relevance 0.17
In WT SNs, there was a rapid increase in total APP levels within 5 min of DHPG treatment (1.6-fold, n = 3), which was completely absent in KO SNs.
Positive_regulation (increase) of APP associated with targeted disruption
10) Confidence 0.60 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.63 Pain Relevance 0
These data confirm our findings in SNs that (1) fmr-1 KO mice have higher basal synaptic levels of APP, and (2) DHPG increases APP levels selectively in WT samples.
Positive_regulation (increases) of APP associated with targeted disruption
11) Confidence 0.60 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.79 Pain Relevance 0.07
protein generation by upregulating the APP processing enzymes BACE and PSEN-1 [28–30].
Positive_regulation (upregulating) of APP
12) Confidence 0.58 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.71 Pain Relevance 0
As was found, injections of atropine (21 days, 5mg/kg/day) increase Abeta levels in aged but not young animals.
Positive_regulation (increase) of Abeta associated with abeta
13) Confidence 0.58 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20540990 Disease Relevance 0.16 Pain Relevance 0.51
Similar observations were made for fenofibrate, a compound known to increase Abeta(42) and to decrease Abeta(38).
Positive_regulation (increase) of Abeta associated with abeta
14) Confidence 0.56 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17962197 Disease Relevance 0.63 Pain Relevance 0.78
Work in a porcine model of head injury has shown accumulation of APP and BACE in injured axons and it is suggested that the abnormal accumulation of these proteins may favour A?
Positive_regulation (accumulation) of APP in head associated with brain injury
15) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 1.21 Pain Relevance 0.23
Sporadic inclusion body myositis (sIBM) is a common age-related inflammatory myopathy characterized by the presence of intracellular inclusions that contain the amyloid-beta (Abeta) peptide, a derivative of the amyloid precursor protein (APP).
Positive_regulation (derivative) of APP in body associated with inflammation, alzheimer's dementia, inclusion body myositis and abeta
16) Confidence 0.50 Published 2010 Journal Neurobiol. Dis. Section Abstract Doc Link 20493261 Disease Relevance 1.07 Pain Relevance 0.47
Sporadic inclusion body myositis (sIBM) is a common age-related inflammatory myopathy characterized by the presence of intracellular inclusions that contain the amyloid-beta (Abeta) peptide, a derivative of the amyloid precursor protein (APP).
Positive_regulation (derivative) of amyloid precursor protein in body associated with inflammation, alzheimer's dementia, inclusion body myositis and abeta
17) Confidence 0.50 Published 2010 Journal Neurobiol. Dis. Section Abstract Doc Link 20493261 Disease Relevance 1.07 Pain Relevance 0.47
Yet, copper exposure in 3xTg mice led to elevated steady-state levels of APP, and C99 as well as to increased A?
Positive_regulation (increased) of APP
18) Confidence 0.50 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.74 Pain Relevance 0.14
A YAC containing the hAPP gene encoding APP harboring the Swedish mutation, the London mutation or a combination of the two increased the A?
Positive_regulation (encoding) of APP
19) Confidence 0.50 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.60 Pain Relevance 0.06
Antagonizing the extracellular interaction between cell-surface APP and LRP increased the level of cell surface APP while decreasing A?
Positive_regulation (surface) of APP
20) Confidence 0.50 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.47 Pain Relevance 0

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