INT47715

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.72

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mitochondrion (Cyp11a1) oxidoreductase activity (Cyp11a1) lipid metabolic process (Cyp11a1)
Cyp11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that GSH concentration was decreased concentration-dependently by acetaminophen in the in vitro P450 enzyme system.
Negative_regulation (decreased) of P450 enzyme associated with paracetamol
1) Confidence 0.42 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10952066 Disease Relevance 0 Pain Relevance 0.64
OA treatment also decreased several P450 enzyme activities, such as coumarin 7-hydroxylation (45%), 7-pentoxyresorufin O-dealkylation (35%), 7-ethoxyresorufin O-dealkylation (25%) and chlorzoxazone 6-hydroxylation (20%).
Negative_regulation (decreased) of P450 enzyme
2) Confidence 0.04 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7473165 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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