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Context Info
Confidence 0.02
First Reported 1995
Last Reported 1995
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.05

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signal transduction (Gpr143) Golgi apparatus (Gpr143) plasma membrane (Gpr143)
lysosome (Gpr143) signal transducer activity (Gpr143)
Anatomy Link Frequency
liver 1
Gpr143 (Mus musculus)
Cyp3a62 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 1 53.96 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with enzyme activities, OA decreased the amounts of mouse liver CYP1A and CYP2A enzymes, but had no appreciable effect on CYP3A enzymes, as determined by immunoblotting with antibodies against rat P450 enzymes.
OA Neg (no) Regulation (effect) of CYP3A in liver
1) Confidence 0.02 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7473165 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

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